Purpose: The aim of this study was to determine whether patients with heart failure (HF) have distinct profiles of cognitive impairment. Background: Cognitive impairment is common in HF. Recent work found three cognitive profiles in HF patients-(1) intact, (2) impaired, and (3) memory-impaired. We examined the reproducibility of these profiles and clarified mechanisms. Methods: HF patients (68.6. ±. 9.7. years; N=. 329) completed neuropsychological testing. Composite scores were created for cognitive domains and used to identify clusters via agglomerative-hierarchical cluster analysis. Results: A 3-cluster solution emerged. Cluster 1 (. n=. 109) had intact cognition. Cluster 2 (. n=. 123) was impaired across all domains. Cluster 3 (. n=. 97) had impaired memory only. Clusters differed in age, race, education, SES, IQ, BMI, and diabetes (. ps. ≤. .026) but not in mood, anxiety, cardiovascular, or pulmonary disease (. ps. ≥. .118). Conclusions: We replicated three distinct patterns of cognitive function in persons with HF. These profiles may help providers offer tailored care to patients with different cognitive and clinical needs.
- Cardiovascular disease
- Cluster analysis
- Cognitive profiles
- Neuropsychological performance
- Older adults