TY - JOUR
T1 - Vitamin D Status Is Associated With Grip Strength in Centenarians
AU - Haslam, Alyson
AU - Johnson, Mary Ann
AU - Hausman, Dorothy B.
AU - Cress, M. Elaine
AU - Houston, Denise K.
AU - Davey, Adam
AU - Poon, Leonard W.
N1 - Funding Information:
This work was supported by the National Institute on Aging at the National Institutes of Health (1P01-AG17553; L.W.P., PI) and the National Institute of Food and Agriculture at the United States Department of Agriculture (HATCH #GEO00708, M.A.J., PI)
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Low serum concentrations of 25-hydroxyvitamin D (25(OH)D) have been associated with poor physical function in older adults, but few, if any, studies have examined this relationship in the very old. Therefore, the purpose of this study is to examine this relationship in the very old. Serum 25(OH)D concentrations were obtained from 194 centenarians and near centenarians (98 years and older). The associations between 25(OH)D concentrations and measures of physical function were evaluated with unadjusted and adjusted regression models. We found that 35% of centenarians had 25(OH)D concentrations less than 50nmol/L. Adjusted mean grip strength was lower for centenarians with 25(OH)D concentrations less than 75nmol/L than for centenarians with higher concentrations (P<0.05). However, there were no differences in the Georgia Centenarian Study (GCS) Composite Scale, a global measure of physical function, between those with higher and lower 25(OH)D concentrations. We conclude that low 25(OH)D concentrations are associated with poor grip strength, but not GCS Composite Scale, in the very old. Considering the high burden of poor physical function in older adults, understanding the relationship between vitamin D and different measures of physical function, including strength, becomes increasingly important.
AB - Low serum concentrations of 25-hydroxyvitamin D (25(OH)D) have been associated with poor physical function in older adults, but few, if any, studies have examined this relationship in the very old. Therefore, the purpose of this study is to examine this relationship in the very old. Serum 25(OH)D concentrations were obtained from 194 centenarians and near centenarians (98 years and older). The associations between 25(OH)D concentrations and measures of physical function were evaluated with unadjusted and adjusted regression models. We found that 35% of centenarians had 25(OH)D concentrations less than 50nmol/L. Adjusted mean grip strength was lower for centenarians with 25(OH)D concentrations less than 75nmol/L than for centenarians with higher concentrations (P<0.05). However, there were no differences in the Georgia Centenarian Study (GCS) Composite Scale, a global measure of physical function, between those with higher and lower 25(OH)D concentrations. We conclude that low 25(OH)D concentrations are associated with poor grip strength, but not GCS Composite Scale, in the very old. Considering the high burden of poor physical function in older adults, understanding the relationship between vitamin D and different measures of physical function, including strength, becomes increasingly important.
KW - cross-sectional study
KW - grip strength
KW - physical function
KW - vitamin D
UR - http://www.scopus.com/inward/record.url?scp=84897780919&partnerID=8YFLogxK
U2 - 10.1080/21551197.2013.867825
DO - 10.1080/21551197.2013.867825
M3 - Article
C2 - 24597995
AN - SCOPUS:84897780919
SN - 2155-1197
VL - 33
SP - 35
EP - 46
JO - Journal of Nutrition in Gerontology and Geriatrics
JF - Journal of Nutrition in Gerontology and Geriatrics
IS - 1
ER -