Objectives: It is unclear whether ketamine induces subclinical respiratory depression when administered in dissociative doses intravenously (IV). The authors report a pilot study of capnography in emergency department (ED) pediatric patients receiving ketamine alone for procedural sedation, and describe serial measures of ventilatory response [end-tidal carbon dioxide (EtCO2), respiratory rate, pulse oximetryl. Methods: The authors performed continuous capnography on a convenience sample of 20 ED pediatric patients who received ketamine 1.5 mg/kg IV for procedural sedation. Results: Continuous EtCO2 and pulse oximetry remained essentially unchanged following ketamine injection, and no EtCO2 levels > 47 mm Hg were noted at any point throughout sedation. Conclusions: No hypoventilation was observed in 20 ED pediatric patients receiving ketamine 1.5 mg/kg administered IV over 1 minute. The authors found no evidence of respiratory depressant properties for this dissociative agent.
|Number of pages||6|
|Journal||Academic Emergency Medicine|
|State||Published - 1 Feb 2003|
- Dissociative sedation
- Procedural sedation
- Respiratory depression
- Ventilatory response