Ventilatory response during dissociative sedation in children - A pilot study

Grace Kim, Steven M. Green, T. Kent Denmark, Baruch Krauss

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


Objectives: It is unclear whether ketamine induces subclinical respiratory depression when administered in dissociative doses intravenously (IV). The authors report a pilot study of capnography in emergency department (ED) pediatric patients receiving ketamine alone for procedural sedation, and describe serial measures of ventilatory response [end-tidal carbon dioxide (EtCO2), respiratory rate, pulse oximetryl. Methods: The authors performed continuous capnography on a convenience sample of 20 ED pediatric patients who received ketamine 1.5 mg/kg IV for procedural sedation. Results: Continuous EtCO2 and pulse oximetry remained essentially unchanged following ketamine injection, and no EtCO2 levels > 47 mm Hg were noted at any point throughout sedation. Conclusions: No hypoventilation was observed in 20 ED pediatric patients receiving ketamine 1.5 mg/kg administered IV over 1 minute. The authors found no evidence of respiratory depressant properties for this dissociative agent.

Original languageEnglish
Pages (from-to)140-145
Number of pages6
JournalAcademic Emergency Medicine
Issue number2
StatePublished - 1 Feb 2003
Externally publishedYes


  • Capnography
  • Dissociative sedation
  • Ketamine
  • Procedural sedation
  • Respiratory depression
  • Sedation
  • Ventilatory response


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