TY - JOUR
T1 - Vasopressin SNP pain factors and stress in sickle cell disease
AU - Powell-Roach, Keesha L.
AU - Yao, Yingwei
AU - Jhun, Ellie H.
AU - He, Ying
AU - Suarez, Marie L.
AU - Ezenwa, Miriam O.
AU - Molokie, Robert E.
AU - Wang, Zaijie Jim
AU - Wilkie, Diana J.
N1 - Funding Information:
The study was approved by the Institutional Review Boards at the University of Illinois at Chicago and the University of Florida. The IRB numbers for this manuscript are: QST: 2014-0287 and SC PAIN: 2006-0266. All participants for this study provided written informed consent. The study was supported by grant numbers R01HL12495, R01HL124945S, R01HL1249451, U54HL117658 for the National Institutes of Health, National Heart Lung & Blood Institute (NHLBI), T32AG049673 from the National Institutes of Aging (NIA), T32DE018381 National Institute of Dental and Craniofacial Research (NIDCR), and the Robert Wood Johnson Future of Nursing Scholars Program. Its contents are solely the responsibility of authors and do not necessarily represent the official views of the NIH, NHLBI, NIA, NIDCR, or the Robert Wood Johnson foundation. The final peer-reviewed manuscript is subject to the National Institutes of Health Public Access Policy. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We thank the patients and staff members at the University of Illinois at Chicago Adult Sickle Cell Clinic for their dedication to this study. The contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH or NHLBI. The final peer-reviewed manuscript is subject to the National Institutes of Health Public Access Policy.
Publisher Copyright:
© 2019 Powell-Roach et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2019/11/1
Y1 - 2019/11/1
N2 - Purpose Frequencies of single nucleotide polymorphisms (SNPs) from pain related candidate genes are available for individuals with sickle cell disease (SCD). One of those genes, the arginine vasopressin receptor 1A gene (AVPR1A) and one of its SNPs, rs10877969, has been associated with pain and disability in other pain populations. In patients with SCD, clinical factors such as pain and stress have been associated with increased health care utilization, but it is not known if the presence of the AVPR1A SNP plays a role in this observation. The study purpose was to explore the relationships between rs10877969 and self-reported pain, stress, and acute care utilization events among individuals with SCD. Methods In a cross-sectional investigation of outpatients with SCD, participants completed PAINReportIt®, a computerized pain measure, to describe their pain experience and contributed blood or saliva samples for genetic analysis. We extracted emergency department and acute care utilization from medical records. Results The SNP genotype frequencies (%) for this sample were CC 30 (28%), CT 44 (41%), TT 33 (31%). Acute care utilization and stress as an aggravator of pain were significantly associated with the rs10877969 genotype (p = .02 and p = .002, respectively). The CT genotype had the highest mean utilization and CC genotype was associated with not citing stress as a pain aggravator. Chronic pain was not associated with rs10877969 (p = .41). Conclusion This study shows that rs10877969 is related to indicators of stress and acute pain. Further research is recommended with other measures of stress and acute pain.
AB - Purpose Frequencies of single nucleotide polymorphisms (SNPs) from pain related candidate genes are available for individuals with sickle cell disease (SCD). One of those genes, the arginine vasopressin receptor 1A gene (AVPR1A) and one of its SNPs, rs10877969, has been associated with pain and disability in other pain populations. In patients with SCD, clinical factors such as pain and stress have been associated with increased health care utilization, but it is not known if the presence of the AVPR1A SNP plays a role in this observation. The study purpose was to explore the relationships between rs10877969 and self-reported pain, stress, and acute care utilization events among individuals with SCD. Methods In a cross-sectional investigation of outpatients with SCD, participants completed PAINReportIt®, a computerized pain measure, to describe their pain experience and contributed blood or saliva samples for genetic analysis. We extracted emergency department and acute care utilization from medical records. Results The SNP genotype frequencies (%) for this sample were CC 30 (28%), CT 44 (41%), TT 33 (31%). Acute care utilization and stress as an aggravator of pain were significantly associated with the rs10877969 genotype (p = .02 and p = .002, respectively). The CT genotype had the highest mean utilization and CC genotype was associated with not citing stress as a pain aggravator. Chronic pain was not associated with rs10877969 (p = .41). Conclusion This study shows that rs10877969 is related to indicators of stress and acute pain. Further research is recommended with other measures of stress and acute pain.
UR - http://www.scopus.com/inward/record.url?scp=85074781103&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0224886
DO - 10.1371/journal.pone.0224886
M3 - Article
C2 - 31710639
AN - SCOPUS:85074781103
SN - 1932-6203
VL - 14
JO - PLoS ONE
JF - PLoS ONE
IS - 11
M1 - e0224886
ER -