Using predictive analytics to identify drug-resistant epilepsy patients

Dursun Delen, Behrooz Davazdahemami, Enes Eryarsoy, Leman Tomak, Abhinav Valluru

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Epilepsy is one of the most common brain disorders that greatly affects patients’ quality of life and poses serious risks to their health. While the majority of the patients positively respond to the existing anti-epilepsy drugs, others who developed the refractory type of epilepsy show resistance against drug therapy and need to undergo advance treatments such as surgery. Given that identifying such patients is not a straightforward process and requires long courses of trial and error with anti-epilepsy drugs, this study aims at predicting those at-risk patients using clinical and demographic data obtained from electronic medical records. Specifically, the study employs several predictive analytics machine-learning methods, equipped with a novel approach for data balancing, to identify drug-resistant patients using their comorbidities and demographic information along with the initial epilepsy-related diagnosis made by their physician. The promising results we obtained highlight the potential use of machine-learning techniques in facilitating medical decisions and suggest the possibility of extending the proposed approach for developing a clinical decision support system for medical professionals.

Original languageEnglish
JournalHealth Informatics Journal
StateAccepted/In press - 1 Jan 2019
Externally publishedYes


  • anti-epileptic drugs
  • drug resistance
  • epilepsy
  • machine learning
  • predictive analytics
  • refractory epilepsy


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