Use of daptomycin in a pregnant patient with Staphylococcus aureus endocarditis

Jeffrey Stroup, James Wagner, Terry Badzinski

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

objective: To report on 6 weeks of daptomycin treatment for tricuspid valve endocarditis caused by Staphylococcus aureus in a pregnant female in her second trimester. case summary: A 24-year-old, 14-week pregnant patient with no significant medical history, but with a history of intravenous drug abuse presented with tricuspid valve endocarditis caused by methicillin-sensitive S. aureus. After initial treatment with vancomycin, the patient continued to have fever and bacteremia and was initiated on daptomycin 6 mg/kg for 6 weeks of therapy. The treatment resulted in the resolution of the endocarditis, and no adverse sequelae were identified in the mother or baby. discussion: Infective endocarditis is a common infection encountered in the hospital setting and represents an increased cost burden to institutions due to prolonged lengths of treatment. Antimicrobial resistance, antimicrobial failure, inadequate attainment of effective drug concentrations, drug allergies, and adverse reactions may be factors that limit the use of commonly utilized antimicrobial agents. Therefore, newer therapies like daptomycin may need to be employed in these situations. Although daptomycin is pregnancy category B, limited case reports with neonatal outcomes are reported. conclusions: This case provides further support for the safety of daptomycin in pregnancy with the dose of 6 mg/kg, the extended duration of therapy (6 weeks), and the primary exposure in the second trimester.

Original languageEnglish
Pages (from-to)746-749
Number of pages4
JournalAnnals of Pharmacotherapy
Volume44
Issue number4
DOIs
StatePublished - 1 Apr 2010

Fingerprint

Daptomycin
Endocarditis
Staphylococcus aureus
Tricuspid Valve
Second Pregnancy Trimester
Therapeutics
Intravenous Substance Abuse
Drug Hypersensitivity
Pregnancy
Methicillin
Vancomycin
Bacteremia
Anti-Infective Agents
Fever
Mothers
Safety
Costs and Cost Analysis
Infection

Keywords

  • Daptomycin
  • Endocarditis
  • Pregnancy
  • S. aureus

Cite this

Stroup, Jeffrey ; Wagner, James ; Badzinski, Terry. / Use of daptomycin in a pregnant patient with Staphylococcus aureus endocarditis. In: Annals of Pharmacotherapy. 2010 ; Vol. 44, No. 4. pp. 746-749.
@article{4d75b8331ede41d08db5c8f3a5ac8f8f,
title = "Use of daptomycin in a pregnant patient with Staphylococcus aureus endocarditis",
abstract = "objective: To report on 6 weeks of daptomycin treatment for tricuspid valve endocarditis caused by Staphylococcus aureus in a pregnant female in her second trimester. case summary: A 24-year-old, 14-week pregnant patient with no significant medical history, but with a history of intravenous drug abuse presented with tricuspid valve endocarditis caused by methicillin-sensitive S. aureus. After initial treatment with vancomycin, the patient continued to have fever and bacteremia and was initiated on daptomycin 6 mg/kg for 6 weeks of therapy. The treatment resulted in the resolution of the endocarditis, and no adverse sequelae were identified in the mother or baby. discussion: Infective endocarditis is a common infection encountered in the hospital setting and represents an increased cost burden to institutions due to prolonged lengths of treatment. Antimicrobial resistance, antimicrobial failure, inadequate attainment of effective drug concentrations, drug allergies, and adverse reactions may be factors that limit the use of commonly utilized antimicrobial agents. Therefore, newer therapies like daptomycin may need to be employed in these situations. Although daptomycin is pregnancy category B, limited case reports with neonatal outcomes are reported. conclusions: This case provides further support for the safety of daptomycin in pregnancy with the dose of 6 mg/kg, the extended duration of therapy (6 weeks), and the primary exposure in the second trimester.",
keywords = "Daptomycin, Endocarditis, Pregnancy, S. aureus",
author = "Jeffrey Stroup and James Wagner and Terry Badzinski",
year = "2010",
month = "4",
day = "1",
doi = "10.1345/aph.1M650",
language = "English",
volume = "44",
pages = "746--749",
journal = "Annals of Pharmacotherapy",
issn = "1060-0280",
publisher = "SAGE Publications Inc.",
number = "4",

}

Use of daptomycin in a pregnant patient with Staphylococcus aureus endocarditis. / Stroup, Jeffrey; Wagner, James; Badzinski, Terry.

In: Annals of Pharmacotherapy, Vol. 44, No. 4, 01.04.2010, p. 746-749.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Use of daptomycin in a pregnant patient with Staphylococcus aureus endocarditis

AU - Stroup, Jeffrey

AU - Wagner, James

AU - Badzinski, Terry

PY - 2010/4/1

Y1 - 2010/4/1

N2 - objective: To report on 6 weeks of daptomycin treatment for tricuspid valve endocarditis caused by Staphylococcus aureus in a pregnant female in her second trimester. case summary: A 24-year-old, 14-week pregnant patient with no significant medical history, but with a history of intravenous drug abuse presented with tricuspid valve endocarditis caused by methicillin-sensitive S. aureus. After initial treatment with vancomycin, the patient continued to have fever and bacteremia and was initiated on daptomycin 6 mg/kg for 6 weeks of therapy. The treatment resulted in the resolution of the endocarditis, and no adverse sequelae were identified in the mother or baby. discussion: Infective endocarditis is a common infection encountered in the hospital setting and represents an increased cost burden to institutions due to prolonged lengths of treatment. Antimicrobial resistance, antimicrobial failure, inadequate attainment of effective drug concentrations, drug allergies, and adverse reactions may be factors that limit the use of commonly utilized antimicrobial agents. Therefore, newer therapies like daptomycin may need to be employed in these situations. Although daptomycin is pregnancy category B, limited case reports with neonatal outcomes are reported. conclusions: This case provides further support for the safety of daptomycin in pregnancy with the dose of 6 mg/kg, the extended duration of therapy (6 weeks), and the primary exposure in the second trimester.

AB - objective: To report on 6 weeks of daptomycin treatment for tricuspid valve endocarditis caused by Staphylococcus aureus in a pregnant female in her second trimester. case summary: A 24-year-old, 14-week pregnant patient with no significant medical history, but with a history of intravenous drug abuse presented with tricuspid valve endocarditis caused by methicillin-sensitive S. aureus. After initial treatment with vancomycin, the patient continued to have fever and bacteremia and was initiated on daptomycin 6 mg/kg for 6 weeks of therapy. The treatment resulted in the resolution of the endocarditis, and no adverse sequelae were identified in the mother or baby. discussion: Infective endocarditis is a common infection encountered in the hospital setting and represents an increased cost burden to institutions due to prolonged lengths of treatment. Antimicrobial resistance, antimicrobial failure, inadequate attainment of effective drug concentrations, drug allergies, and adverse reactions may be factors that limit the use of commonly utilized antimicrobial agents. Therefore, newer therapies like daptomycin may need to be employed in these situations. Although daptomycin is pregnancy category B, limited case reports with neonatal outcomes are reported. conclusions: This case provides further support for the safety of daptomycin in pregnancy with the dose of 6 mg/kg, the extended duration of therapy (6 weeks), and the primary exposure in the second trimester.

KW - Daptomycin

KW - Endocarditis

KW - Pregnancy

KW - S. aureus

UR - http://www.scopus.com/inward/record.url?scp=77950619270&partnerID=8YFLogxK

U2 - 10.1345/aph.1M650

DO - 10.1345/aph.1M650

M3 - Article

C2 - 20197474

AN - SCOPUS:77950619270

VL - 44

SP - 746

EP - 749

JO - Annals of Pharmacotherapy

JF - Annals of Pharmacotherapy

SN - 1060-0280

IS - 4

ER -