Urinary leukotriene E4 levels increase upon exposure to hypobaric hypoxia

James M. Roach, Stephen R. Muza, Paul Rock, Timothy P. Lyons, Craig M. Lilly, Jeffrey M. Drazen, Allen Cymerman

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Study objective: To determine whether urinary leukotriene E4 (uLTE4) levels increase upon exposure to high altitude, and also to ascertain the relationship between uLTE4 levels and symptoms of acute mountain sickness (AMS). Design: Prospective, unblinded, single-factor (altitude) experimental study. Settings: US Army research laboratory facilities at sea level ([SL] 50 m), 1,830 m, and 4,360 m. Participants: Eight healthy male subjects ranging in age from 19 to 24 years. Measurements: uLTE4 levels and symptoms of AMS were measured at just above SL (50 m), 3 1/4 days after being transported from SL to moderate altitude (MA) (1,830 m), and 1 1/4 days after ascent from 1,830 to 4,300 m (high altitude [HA]). Symptoms of AMS were assessed using standard indexes derived from the Environmental Symptoms Questionnaire weighted toward cerebral (AMS-C) and respiratory (AMS-R) manifestations. Oxygen saturation was measured noninvasively by pulse oximetry at SL and HA. Results: The mean (± SEM) uLTE4 levels (pg/mg creatinine) were 67.9 (± 13.2) at SL; 82.3 (± 5.5) at MA; and 134.8 (± 19.4) at HA (p<0.05 comparing HA with SL and MA). Conclusions: We conclude that uLTE4 levels increase shortly after exposure to HA even after staging for 4 days at MA. Although this study does not clearly demonstrate a relationship between uLTE4 levels and symptoms of AMS, it supports the hypothesis that leukotrienes may be involved in the pathophysiologic state of AMS.

Original languageEnglish
Pages (from-to)946-951
Number of pages6
JournalChest
Volume110
Issue number4
DOIs
StatePublished - 1 Jan 1996

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Leukotriene E4
Altitude Sickness
Oceans and Seas
Hypoxia
Oximetry
Leukotrienes
Creatinine
Healthy Volunteers

Keywords

  • altitude
  • altitude sickness
  • leukotrienes

Cite this

Roach, J. M., Muza, S. R., Rock, P., Lyons, T. P., Lilly, C. M., Drazen, J. M., & Cymerman, A. (1996). Urinary leukotriene E4 levels increase upon exposure to hypobaric hypoxia. Chest, 110(4), 946-951. https://doi.org/10.1378/chest.110.4.946
Roach, James M. ; Muza, Stephen R. ; Rock, Paul ; Lyons, Timothy P. ; Lilly, Craig M. ; Drazen, Jeffrey M. ; Cymerman, Allen. / Urinary leukotriene E4 levels increase upon exposure to hypobaric hypoxia. In: Chest. 1996 ; Vol. 110, No. 4. pp. 946-951.
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abstract = "Study objective: To determine whether urinary leukotriene E4 (uLTE4) levels increase upon exposure to high altitude, and also to ascertain the relationship between uLTE4 levels and symptoms of acute mountain sickness (AMS). Design: Prospective, unblinded, single-factor (altitude) experimental study. Settings: US Army research laboratory facilities at sea level ([SL] 50 m), 1,830 m, and 4,360 m. Participants: Eight healthy male subjects ranging in age from 19 to 24 years. Measurements: uLTE4 levels and symptoms of AMS were measured at just above SL (50 m), 3 1/4 days after being transported from SL to moderate altitude (MA) (1,830 m), and 1 1/4 days after ascent from 1,830 to 4,300 m (high altitude [HA]). Symptoms of AMS were assessed using standard indexes derived from the Environmental Symptoms Questionnaire weighted toward cerebral (AMS-C) and respiratory (AMS-R) manifestations. Oxygen saturation was measured noninvasively by pulse oximetry at SL and HA. Results: The mean (± SEM) uLTE4 levels (pg/mg creatinine) were 67.9 (± 13.2) at SL; 82.3 (± 5.5) at MA; and 134.8 (± 19.4) at HA (p<0.05 comparing HA with SL and MA). Conclusions: We conclude that uLTE4 levels increase shortly after exposure to HA even after staging for 4 days at MA. Although this study does not clearly demonstrate a relationship between uLTE4 levels and symptoms of AMS, it supports the hypothesis that leukotrienes may be involved in the pathophysiologic state of AMS.",
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Roach, JM, Muza, SR, Rock, P, Lyons, TP, Lilly, CM, Drazen, JM & Cymerman, A 1996, 'Urinary leukotriene E4 levels increase upon exposure to hypobaric hypoxia', Chest, vol. 110, no. 4, pp. 946-951. https://doi.org/10.1378/chest.110.4.946

Urinary leukotriene E4 levels increase upon exposure to hypobaric hypoxia. / Roach, James M.; Muza, Stephen R.; Rock, Paul; Lyons, Timothy P.; Lilly, Craig M.; Drazen, Jeffrey M.; Cymerman, Allen.

In: Chest, Vol. 110, No. 4, 01.01.1996, p. 946-951.

Research output: Contribution to journalArticle

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AU - Roach, James M.

AU - Muza, Stephen R.

AU - Rock, Paul

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AU - Drazen, Jeffrey M.

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Roach JM, Muza SR, Rock P, Lyons TP, Lilly CM, Drazen JM et al. Urinary leukotriene E4 levels increase upon exposure to hypobaric hypoxia. Chest. 1996 Jan 1;110(4):946-951. https://doi.org/10.1378/chest.110.4.946