Understanding depression: the hippocampus might hold the answer in a CREB-regulated transcription coactivator: An Editorial for ‘AAV-mediated over-expression of CRTC1 in the hippocampal dentate gyrus ameliorates lipopolysaccharide-induced depression-like behavior in mice’ on page 111.

Research output: Contribution to journalEditorial

Abstract

The pathophysiology of major depressive disorders is not completely understood. In this issue of Journal of Neurochemistry, Ni and colleagues investigate the role of cyclic adenosine monophosphate response element-binding protein (CREB)-dependent signaling in the hippocampus on depressive-like behaviors. This editorial highlights the key findings reported by Ni et al., (2018) and how they demonstrated the importance of CREB-regulated transcription cofactor 1 in LPS-induced neuroinflammation and depressive-like behaviors. (Figure presented.).

Original languageEnglish
Pages (from-to)9-11
Number of pages3
JournalJournal of Neurochemistry
Volume149
Issue number1
DOIs
StatePublished - 1 Apr 2019

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CREB-Binding Protein
Parahippocampal Gyrus
Dentate Gyrus
Response Elements
Transcription
Cyclic AMP
Lipopolysaccharides
Hippocampus
Depression
Neurochemistry
Major Depressive Disorder

Cite this

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title = "Understanding depression: the hippocampus might hold the answer in a CREB-regulated transcription coactivator: An Editorial for ‘AAV-mediated over-expression of CRTC1 in the hippocampal dentate gyrus ameliorates lipopolysaccharide-induced depression-like behavior in mice’ on page 111.",
abstract = "The pathophysiology of major depressive disorders is not completely understood. In this issue of Journal of Neurochemistry, Ni and colleagues investigate the role of cyclic adenosine monophosphate response element-binding protein (CREB)-dependent signaling in the hippocampus on depressive-like behaviors. This editorial highlights the key findings reported by Ni et al., (2018) and how they demonstrated the importance of CREB-regulated transcription cofactor 1 in LPS-induced neuroinflammation and depressive-like behaviors. (Figure presented.).",
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