Understanding depression: the hippocampus might hold the answer in a CREB-regulated transcription coactivator: An Editorial for ‘AAV-mediated over-expression of CRTC1 in the hippocampal dentate gyrus ameliorates lipopolysaccharide-induced depression-like behavior in mice’ on page 111.

Research output: Contribution to journalEditorial


The pathophysiology of major depressive disorders is not completely understood. In this issue of Journal of Neurochemistry, Ni and colleagues investigate the role of cyclic adenosine monophosphate response element-binding protein (CREB)-dependent signaling in the hippocampus on depressive-like behaviors. This editorial highlights the key findings reported by Ni et al., (2018) and how they demonstrated the importance of CREB-regulated transcription cofactor 1 in LPS-induced neuroinflammation and depressive-like behaviors. (Figure presented.).

Original languageEnglish
Pages (from-to)9-11
Number of pages3
JournalJournal of Neurochemistry
Issue number1
Publication statusPublished - 1 Apr 2019


Cite this