Treating schizophrenia: The quality of evidence behind treatment recommendations and how it can improve

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Objective: To assess the methodological and reporting quality of systematic reviews that comprise the American Psychiatric Association (APA) Practice Guideline for the Treatment ofPatientswith Schizophrenia and to determine the extent to which results from Cochrane systematic reviews published after guideline development would alter or confirm current recommendations. Participants: Systematic reviews that underpinned recommendations in the APA guidelines and Cochrane systematic reviews. Main outcome: Three independent reviewers scored all systematic reviews referenced in the guideline for quality and reporting using AMSTAR and PRISMA checklist, respectively. Items in both tools were individually graded and compared to identify consistently low-performing areas within the systematic reviews. Post hoc analysis of the Cochrane systematic reviews since the latest revision of APA's guidelines were performed to determine whether their findings were congruent with recent recommendations. Results: The mean score of the 57 reviews on the PRISMA checklist was 70%. The mean AMSTAR score was 6.8, correlating with a moderate quality score. Post hoc analysis revealed that 171 Cochrane reviews had been published since the APA guideline release. Only half of the reviews of pharmacological interventions confirmed current recommendations. Conclusions and relevance: The methodological quality of the systematic reviews included in the APA guideline was deficient in key areas. Our study brings to light the importance of using high-quality evidence in the development of clinical practice guidelines. An updated APA guideline (last updated in 2009) is necessary to provide the highest quality treatment recommendations for clinicians in the management of schizophrenia. Trial registration number: UMIN-CTR, UMIN000023099.

Original languageEnglish
Pages (from-to)137-151
Number of pages15
JournalBMJ Evidence-Based Medicine
Issue number4
StateAccepted/In press - 1 Jan 2019


  • american psychiatry association
  • cochrane
  • guidelines
  • schizophrenia
  • systematic reviews


Dive into the research topics of 'Treating schizophrenia: The quality of evidence behind treatment recommendations and how it can improve'. Together they form a unique fingerprint.

Cite this