Transient receptor potential polymorphism and haplotype associate with crisis pain in sickle cell disease

Ellie H. Jhun; Xiaoyu Hu; Nilanjana Sadhu; Yingwei Yao; Ying He; Diana J. Wilkie; Robert E. Molokie; Zaijie J. Wang

doi:10.2217/pgs-2017-0198

Transient receptor potential polymorphism and haplotype associate with crisis pain in sickle cell disease

Ellie H. Jhun, Xiaoyu Hu, Nilanjana Sadhu, Yingwei Yao, Ying He, Diana J. Wilkie, Robert E. Molokie, Zaijie J. Wang

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Aim: Episodes of acute pain crisis contribute to considerable morbidity and mortality in sickle cell disease (SCD). Incomprehensive understanding of the underlying pain heterogeneity results in inadequate pain management. The transient receptor potential (TRP) family of voltage-gated ion channels acts as sensory transducers of diverse noxious stimuli. We performed an association study of polymorphisms in candidate genes TRPV1 and TRPA1 with pain in SCD patients. Methods: Utilization rate, in other words, number of emergency department/acute care center admissions over 12 months as a result of pain crisis, served as a marker for acute pain. Results & conclusion: We identified that rs920829 (incident rate ratio = 1.44, p = 0.027 additive; IRR=1.68, p=0.008 recessive models of negative binomial regression) and the CGAGG haplotype of TRPA1 (odds ratio = 0.218, p = 0.009) were significantly associated with utilization rate, suggesting that TRPA1 gene polymorphisms may influence acute pain crisis in SCD.

Original language	English
Pages (from-to)	401-411
Number of pages	11
Journal	Pharmacogenomics
Volume	19
Issue number	5
DOIs	https://doi.org/10.2217/pgs-2017-0198
State	Published - Apr 2018
Externally published	Yes

Keywords

pain crisis
polymorphism
transient receptor potential
TRPA1
TRPV1

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@article{015daf6658a84fff93b2a8630d147e23,

title = "Transient receptor potential polymorphism and haplotype associate with crisis pain in sickle cell disease",

abstract = "Aim: Episodes of acute pain crisis contribute to considerable morbidity and mortality in sickle cell disease (SCD). Incomprehensive understanding of the underlying pain heterogeneity results in inadequate pain management. The transient receptor potential (TRP) family of voltage-gated ion channels acts as sensory transducers of diverse noxious stimuli. We performed an association study of polymorphisms in candidate genes TRPV1 and TRPA1 with pain in SCD patients. Methods: Utilization rate, in other words, number of emergency department/acute care center admissions over 12 months as a result of pain crisis, served as a marker for acute pain. Results & conclusion: We identified that rs920829 (incident rate ratio = 1.44, p = 0.027 additive; IRR=1.68, p=0.008 recessive models of negative binomial regression) and the CGAGG haplotype of TRPA1 (odds ratio = 0.218, p = 0.009) were significantly associated with utilization rate, suggesting that TRPA1 gene polymorphisms may influence acute pain crisis in SCD.",

keywords = "pain crisis, polymorphism, transient receptor potential, TRPA1, TRPV1",

author = "Jhun, {Ellie H.} and Xiaoyu Hu and Nilanjana Sadhu and Yingwei Yao and Ying He and Wilkie, {Diana J.} and Molokie, {Robert E.} and Wang, {Zaijie J.}",

note = "Funding Information: The study was supported in part by funds from the Illinois Department of Public Health (IDPH) and grants R01HL124945, R01HL078536 and R35HL140031 from the National Heart, Lung, and Blood Institute (NHLBI). EH Jhun was supported by a predoctoral fellowship from NIDCR (T32DE018381). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. Publisher Copyright: {\textcopyright} 2018 2018 Future Medicine Ltd.",

year = "2018",

month = apr,

doi = "10.2217/pgs-2017-0198",

language = "English",

volume = "19",

pages = "401--411",

journal = "Pharmacogenomics",

issn = "1462-2416",

publisher = "Future Medicine Ltd.",

number = "5",

}

TY - JOUR

T1 - Transient receptor potential polymorphism and haplotype associate with crisis pain in sickle cell disease

AU - Jhun, Ellie H.

AU - Hu, Xiaoyu

AU - Sadhu, Nilanjana

AU - Yao, Yingwei

AU - He, Ying

AU - Wilkie, Diana J.

AU - Molokie, Robert E.

AU - Wang, Zaijie J.

N1 - Funding Information: The study was supported in part by funds from the Illinois Department of Public Health (IDPH) and grants R01HL124945, R01HL078536 and R35HL140031 from the National Heart, Lung, and Blood Institute (NHLBI). EH Jhun was supported by a predoctoral fellowship from NIDCR (T32DE018381). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. Publisher Copyright: © 2018 2018 Future Medicine Ltd.

PY - 2018/4

Y1 - 2018/4

N2 - Aim: Episodes of acute pain crisis contribute to considerable morbidity and mortality in sickle cell disease (SCD). Incomprehensive understanding of the underlying pain heterogeneity results in inadequate pain management. The transient receptor potential (TRP) family of voltage-gated ion channels acts as sensory transducers of diverse noxious stimuli. We performed an association study of polymorphisms in candidate genes TRPV1 and TRPA1 with pain in SCD patients. Methods: Utilization rate, in other words, number of emergency department/acute care center admissions over 12 months as a result of pain crisis, served as a marker for acute pain. Results & conclusion: We identified that rs920829 (incident rate ratio = 1.44, p = 0.027 additive; IRR=1.68, p=0.008 recessive models of negative binomial regression) and the CGAGG haplotype of TRPA1 (odds ratio = 0.218, p = 0.009) were significantly associated with utilization rate, suggesting that TRPA1 gene polymorphisms may influence acute pain crisis in SCD.

AB - Aim: Episodes of acute pain crisis contribute to considerable morbidity and mortality in sickle cell disease (SCD). Incomprehensive understanding of the underlying pain heterogeneity results in inadequate pain management. The transient receptor potential (TRP) family of voltage-gated ion channels acts as sensory transducers of diverse noxious stimuli. We performed an association study of polymorphisms in candidate genes TRPV1 and TRPA1 with pain in SCD patients. Methods: Utilization rate, in other words, number of emergency department/acute care center admissions over 12 months as a result of pain crisis, served as a marker for acute pain. Results & conclusion: We identified that rs920829 (incident rate ratio = 1.44, p = 0.027 additive; IRR=1.68, p=0.008 recessive models of negative binomial regression) and the CGAGG haplotype of TRPA1 (odds ratio = 0.218, p = 0.009) were significantly associated with utilization rate, suggesting that TRPA1 gene polymorphisms may influence acute pain crisis in SCD.

KW - pain crisis

KW - polymorphism

KW - transient receptor potential

KW - TRPA1

KW - TRPV1

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U2 - 10.2217/pgs-2017-0198

DO - 10.2217/pgs-2017-0198

M3 - Article

C2 - 29620434

AN - SCOPUS:85045413824

SN - 1462-2416

VL - 19

SP - 401

EP - 411

JO - Pharmacogenomics

JF - Pharmacogenomics

IS - 5

ER -

Transient receptor potential polymorphism and haplotype associate with crisis pain in sickle cell disease

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