Time course characteristics of tolerance development to continuously infused antinociceptive agents in rat spinal cord

Keyphrases

• Antinociceptive 100%
• Enkephalin 100%
• Tolerance Development 100%
• Rat Spinal Cord 100%
• Course Characteristics 100%
• Hot Plate 80%
• Sufentanil 60%
• ED50 40%
• Response Latency 40%
• Morphine 20%
• μ-opioid Receptor 20%
• Delta Opioid 20%
• Assay System 20%
• Intrathecal Infusion 20%
• Alpha-2 Agonists 20%
• Exponential Decay 20%
• Infusion Model 20%
• Tolerance Curve 20%
• Continuous Infusion 20%
• Receptor Reserve 20%
• Drug Dosing 20%
• Decay Half-life 20%
• Adaptation 20%
• Latency 20%
• Peak Day 20%
• Second Messenger 20%
• Plate Effects 20%
• A2A Receptor 20%
• Concentration-dependent 20%
• Constant Rate Infusion 20%
• Concentration Effect 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Enkephalin 100%
• Antinociceptive Agent 100%
• Sufentanil 60%
• Opiate 40%
• Receptor 20%
• Morphine 20%
• Intrathecal 20%
• Receptor Reserve 20%
• Drug Dose 20%

Neuroscience

• Enkephalin 100%
• Sufentanil 60%
• Agonist 40%
• Opiate 40%
• Morphine 20%
• Intrathecal 20%
• Second Messenger System 20%
• Receptor Reserve 20%
• Receptor 20%