The use of receptor-selective agents as analgesics in the spinal cord: Trends and possibilities

T. L. Yaksh; P. A.C. Durant; D. M. Gaumann; C. W. Stevens; Erling Mjanger

doi:10.1016/S0885-3924(87)80071-4

The use of receptor-selective agents as analgesics in the spinal cord: Trends and possibilities

T. L. Yaksh, P. A.C. Durant, D. M. Gaumann, C. W. Stevens, Erling Mjanger

Pharmacology and Physiology

Research output: Contribution to journal › Review article

5 Scopus citations

Abstract

This review presents current work on the pharmacology of spinal receptor systems that modulate the processing of nociceptive information. Systems considered are those which might directly block the postsynaptic effects of putative primary afferent neurotransmitters (such as substance P and excitatory amino acids) and those which modulate dorsal systems (opioid, adrenergic, purinergic, neurotensin, cholinergic, GABAergic and somatostatin). Concerns that arise from the spinal use of receptor selective agents are presented and the minimum preclinical studies necessary prior to the use of a novel agent in man are described.

Original language	English
Pages (from-to)	129-138
Number of pages	10
Journal	Journal of Pain and Symptom Management
Volume	2
Issue number	3
DOIs	https://doi.org/10.1016/S0885-3924(87)80071-4
Publication status	Published - 1 Jan 1987

Fingerprint

Keywords

Analgesia and adenosine
adrenergic receptors
opioid receptors
spinal cord and receptor systems
spinal cord and toxicology

Cite this

Yaksh, T. L., Durant, P. A. C., Gaumann, D. M., Stevens, C. W., & Mjanger, E. (1987). The use of receptor-selective agents as analgesics in the spinal cord: Trends and possibilities. Journal of Pain and Symptom Management, 2(3), 129-138. https://doi.org/10.1016/S0885-3924(87)80071-4

@article{c32dc2379166458cab323854035829d2,

title = "The use of receptor-selective agents as analgesics in the spinal cord: Trends and possibilities",

abstract = "This review presents current work on the pharmacology of spinal receptor systems that modulate the processing of nociceptive information. Systems considered are those which might directly block the postsynaptic effects of putative primary afferent neurotransmitters (such as substance P and excitatory amino acids) and those which modulate dorsal systems (opioid, adrenergic, purinergic, neurotensin, cholinergic, GABAergic and somatostatin). Concerns that arise from the spinal use of receptor selective agents are presented and the minimum preclinical studies necessary prior to the use of a novel agent in man are described.",

keywords = "Analgesia and adenosine, adrenergic receptors, opioid receptors, spinal cord and receptor systems, spinal cord and toxicology",

author = "Yaksh, {T. L.} and Durant, {P. A.C.} and Gaumann, {D. M.} and Stevens, {C. W.} and Erling Mjanger",

year = "1987",

month = "1",

day = "1",

doi = "10.1016/S0885-3924(87)80071-4",

language = "English",

volume = "2",

pages = "129--138",

journal = "Journal of Pain and Symptom Management",

issn = "0885-3924",

publisher = "Elsevier Inc.",

number = "3",

}

TY - JOUR

T1 - The use of receptor-selective agents as analgesics in the spinal cord

T2 - Trends and possibilities

AU - Yaksh, T. L.

AU - Durant, P. A.C.

AU - Gaumann, D. M.

AU - Stevens, C. W.

AU - Mjanger, Erling

PY - 1987/1/1

Y1 - 1987/1/1

N2 - This review presents current work on the pharmacology of spinal receptor systems that modulate the processing of nociceptive information. Systems considered are those which might directly block the postsynaptic effects of putative primary afferent neurotransmitters (such as substance P and excitatory amino acids) and those which modulate dorsal systems (opioid, adrenergic, purinergic, neurotensin, cholinergic, GABAergic and somatostatin). Concerns that arise from the spinal use of receptor selective agents are presented and the minimum preclinical studies necessary prior to the use of a novel agent in man are described.

AB - This review presents current work on the pharmacology of spinal receptor systems that modulate the processing of nociceptive information. Systems considered are those which might directly block the postsynaptic effects of putative primary afferent neurotransmitters (such as substance P and excitatory amino acids) and those which modulate dorsal systems (opioid, adrenergic, purinergic, neurotensin, cholinergic, GABAergic and somatostatin). Concerns that arise from the spinal use of receptor selective agents are presented and the minimum preclinical studies necessary prior to the use of a novel agent in man are described.

KW - Analgesia and adenosine

KW - adrenergic receptors

KW - opioid receptors

KW - spinal cord and receptor systems

KW - spinal cord and toxicology

UR - http://www.scopus.com/inward/record.url?scp=0023578845&partnerID=8YFLogxK

U2 - 10.1016/S0885-3924(87)80071-4

DO - 10.1016/S0885-3924(87)80071-4

M3 - Review article

C2 - 3039016

AN - SCOPUS:0023578845

VL - 2

SP - 129

EP - 138

JO - Journal of Pain and Symptom Management

JF - Journal of Pain and Symptom Management

SN - 0885-3924

IS - 3

ER -

Access to Document

10.1016/S0885-3924(87)80071-4

Link to publication in Scopus