This review presents current work on the pharmacology of spinal receptor systems that modulate the processing of nociceptive information. Systems considered are those which might directly block the postsynaptic effects of putative primary afferent neurotransmitters (such as substance P and excitatory amino acids) and those which modulate dorsal systems (opioid, adrenergic, purinergic, neurotensin, cholinergic, GABAergic and somatostatin). Concerns that arise from the spinal use of receptor selective agents are presented and the minimum preclinical studies necessary prior to the use of a novel agent in man are described.
- Analgesia and adenosine
- adrenergic receptors
- opioid receptors
- spinal cord and receptor systems
- spinal cord and toxicology