Abstract
This review presents current work on the pharmacology of spinal receptor systems that modulate the processing of nociceptive information. Systems considered are those which might directly block the postsynaptic effects of putative primary afferent neurotransmitters (such as substance P and excitatory amino acids) and those which modulate dorsal systems (opioid, adrenergic, purinergic, neurotensin, cholinergic, GABAergic and somatostatin). Concerns that arise from the spinal use of receptor selective agents are presented and the minimum preclinical studies necessary prior to the use of a novel agent in man are described.
| Original language | English |
|---|---|
| Pages (from-to) | 129-138 |
| Number of pages | 10 |
| Journal | Journal of Pain and Symptom Management |
| Volume | 2 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1 Jan 1987 |
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Keywords
- Analgesia and adenosine
- adrenergic receptors
- opioid receptors
- spinal cord and receptor systems
- spinal cord and toxicology
Cite this
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The use of receptor-selective agents as analgesics in the spinal cord : Trends and possibilities. / Yaksh, T. L.; Durant, P. A.C.; Gaumann, D. M.; Stevens, Craig; Mjanger, Erling.
In: Journal of Pain and Symptom Management, Vol. 2, No. 3, 01.01.1987, p. 129-138.Research output: Contribution to journal › Review article
TY - JOUR
T1 - The use of receptor-selective agents as analgesics in the spinal cord
T2 - Trends and possibilities
AU - Yaksh, T. L.
AU - Durant, P. A.C.
AU - Gaumann, D. M.
AU - Stevens, Craig
AU - Mjanger, Erling
PY - 1987/1/1
Y1 - 1987/1/1
N2 - This review presents current work on the pharmacology of spinal receptor systems that modulate the processing of nociceptive information. Systems considered are those which might directly block the postsynaptic effects of putative primary afferent neurotransmitters (such as substance P and excitatory amino acids) and those which modulate dorsal systems (opioid, adrenergic, purinergic, neurotensin, cholinergic, GABAergic and somatostatin). Concerns that arise from the spinal use of receptor selective agents are presented and the minimum preclinical studies necessary prior to the use of a novel agent in man are described.
AB - This review presents current work on the pharmacology of spinal receptor systems that modulate the processing of nociceptive information. Systems considered are those which might directly block the postsynaptic effects of putative primary afferent neurotransmitters (such as substance P and excitatory amino acids) and those which modulate dorsal systems (opioid, adrenergic, purinergic, neurotensin, cholinergic, GABAergic and somatostatin). Concerns that arise from the spinal use of receptor selective agents are presented and the minimum preclinical studies necessary prior to the use of a novel agent in man are described.
KW - Analgesia and adenosine
KW - adrenergic receptors
KW - opioid receptors
KW - spinal cord and receptor systems
KW - spinal cord and toxicology
UR - http://www.scopus.com/inward/record.url?scp=0023578845&partnerID=8YFLogxK
U2 - 10.1016/S0885-3924(87)80071-4
DO - 10.1016/S0885-3924(87)80071-4
M3 - Review article
C2 - 3039016
AN - SCOPUS:0023578845
VL - 2
SP - 129
EP - 138
JO - Journal of Pain and Symptom Management
JF - Journal of Pain and Symptom Management
SN - 0885-3924
IS - 3
ER -