The use of receptor-selective agents as analgesics in the spinal cord: Trends and possibilities

T. L. Yaksh; P. A.C. Durant; D. M. Gaumann; C. W. Stevens; Erling Mjanger

doi:10.1016/S0885-3924(87)80071-4

The use of receptor-selective agents as analgesics in the spinal cord: Trends and possibilities

T. L. Yaksh, P. A.C. Durant, D. M. Gaumann, C. W. Stevens, Erling Mjanger

Pharmacology and Physiology

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

This review presents current work on the pharmacology of spinal receptor systems that modulate the processing of nociceptive information. Systems considered are those which might directly block the postsynaptic effects of putative primary afferent neurotransmitters (such as substance P and excitatory amino acids) and those which modulate dorsal systems (opioid, adrenergic, purinergic, neurotensin, cholinergic, GABAergic and somatostatin). Concerns that arise from the spinal use of receptor selective agents are presented and the minimum preclinical studies necessary prior to the use of a novel agent in man are described.

Original language	English
Pages (from-to)	129-138
Number of pages	10
Journal	Journal of Pain and Symptom Management
Volume	2
Issue number	3
DOIs	https://doi.org/10.1016/S0885-3924(87)80071-4
State	Published - 1987

Keywords

Analgesia and adenosine
adrenergic receptors
opioid receptors
spinal cord and receptor systems
spinal cord and toxicology

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10.1016/S0885-3924(87)80071-4

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title = "The use of receptor-selective agents as analgesics in the spinal cord: Trends and possibilities",

abstract = "This review presents current work on the pharmacology of spinal receptor systems that modulate the processing of nociceptive information. Systems considered are those which might directly block the postsynaptic effects of putative primary afferent neurotransmitters (such as substance P and excitatory amino acids) and those which modulate dorsal systems (opioid, adrenergic, purinergic, neurotensin, cholinergic, GABAergic and somatostatin). Concerns that arise from the spinal use of receptor selective agents are presented and the minimum preclinical studies necessary prior to the use of a novel agent in man are described.",

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AU - Stevens, C. W.

AU - Mjanger, Erling

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AB - This review presents current work on the pharmacology of spinal receptor systems that modulate the processing of nociceptive information. Systems considered are those which might directly block the postsynaptic effects of putative primary afferent neurotransmitters (such as substance P and excitatory amino acids) and those which modulate dorsal systems (opioid, adrenergic, purinergic, neurotensin, cholinergic, GABAergic and somatostatin). Concerns that arise from the spinal use of receptor selective agents are presented and the minimum preclinical studies necessary prior to the use of a novel agent in man are described.

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