The RB/E2F pathway and regulation of RNA processing

Joseph Ahlander, Giovanni Bosco

Research output: Contribution to journalShort survey

9 Citations (Scopus)

Abstract

The retinoblastoma tumor suppressor protein (RB) is inactivated in a majority of cancers. RB restricts cell proliferation by inhibiting the E2F family of transcription factors. The current model for RB/E2F function describes its role in regulating transcription at gene promoters. Whether the RB or E2F proteins might play a role in gene expression beyond transcription initiation is not well known. This review describes evidence that points to a novel role for the RB/E2F network in the regulation of RNA processing, and we propose a model as a framework for future research. The elucidation of a novel role of RB in RNA processing will have a profound impact on our understanding of the role of this tumor suppressor family in cell and developmental biology.

Original languageEnglish
Pages (from-to)280-283
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume384
Issue number3
DOIs
StatePublished - 3 Jul 2009
Externally publishedYes

Fingerprint

E2F Transcription Factors
Transcription
Cytology
RNA
Tumor Suppressor Proteins
Developmental Biology
Retinoblastoma Protein
Cell proliferation
Processing
Gene expression
Cell Biology
Tumors
Neoplasms
Transcription Factors
Genes
Cell Proliferation
Gene Expression

Keywords

  • E2F
  • Pre-mRNA splicing
  • RB
  • Retinoblastoma tumor suppressor
  • RNA processing

Cite this

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The RB/E2F pathway and regulation of RNA processing. / Ahlander, Joseph; Bosco, Giovanni.

In: Biochemical and Biophysical Research Communications, Vol. 384, No. 3, 03.07.2009, p. 280-283.

Research output: Contribution to journalShort survey

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AU - Bosco, Giovanni

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