The RB/E2F pathway and regulation of RNA processing

Joseph Ahlander, Giovanni Bosco

Research output: Contribution to journalShort surveypeer-review

9 Scopus citations

Abstract

The retinoblastoma tumor suppressor protein (RB) is inactivated in a majority of cancers. RB restricts cell proliferation by inhibiting the E2F family of transcription factors. The current model for RB/E2F function describes its role in regulating transcription at gene promoters. Whether the RB or E2F proteins might play a role in gene expression beyond transcription initiation is not well known. This review describes evidence that points to a novel role for the RB/E2F network in the regulation of RNA processing, and we propose a model as a framework for future research. The elucidation of a novel role of RB in RNA processing will have a profound impact on our understanding of the role of this tumor suppressor family in cell and developmental biology.

Original languageEnglish
Pages (from-to)280-283
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume384
Issue number3
DOIs
StatePublished - 3 Jul 2009
Externally publishedYes

Keywords

  • E2F
  • Pre-mRNA splicing
  • RB
  • Retinoblastoma tumor suppressor
  • RNA processing

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