Abstract
Baggish, Aaron L., Charles S. Fulco, Stephen Muza, Paul B. Rock, Beth Beidleman, Allen Cymerman, Kibar Yared, Peter Fagenholz, David Systrom, Malissa J. Wood, Arthur E. Weyman, Michael H. Picard, and N. Stuart Harris The impact of moderate altitude on pulmonary arterial hemodynamics after ascent to high altitude. High Alt. Med. Biol. 11:139-145, 2010.-Staged ascent (SA), temporary residence at moderate altitude en route to high altitude, reduces the incidence and severity of noncardiopulmonary altitude illness such as acute mountain sickness. To date, the impact of SA on pulmonary arterial pressure (PAP) is unknown. We tested the hypothesis that SA would attenuate the PAP increase that occurs during rapid, direct ascent (DA). Transthoracic echocardiography was used to estimate mean PAP in 10 healthy males at sea level (SL, PB≈760 torr), after DA to simulated high altitude (hypobaric chamber, P B≈460 torr), and at 2 times points (90min and 4 days) during exposure to terrestrial high altitude (PB≈460 torr) after SA (7 days, moderate altitude, PB≈548 torr). Alveolar oxygen pressure (Pao2) and arterial oxygenation saturation (Sao2) were measured at each time point. Compared to mean PAP at SL (mean±SD, 14±3mmHg), mean PAP increased after DA to 37±8mmHg (Δ=24±10mmHg, p<0.001) and was negatively correlated with both Pao2 (r2=0.57, p=0.011) and Sao2 (r 2=0.64, p=0.005). In comparison, estimated mean PAP after SA increased to only 25±4mmHg (Δ=11±6mmHg, p<0.001), remained unchanged after 4 days of high altitude residence (24±5mmHg, p=not significant, or NS), and did not correlate with either parameter of oxygenation. SA significantly attenuated the PAP increase associated with continuous direct ascent to high altitude and appeared to uncouple PAP from both alveolar hypoxia and arterial hypoxemia.
| Original language | English |
|---|---|
| Pages (from-to) | 139-145 |
| Number of pages | 7 |
| Journal | High Altitude Medicine and Biology |
| Volume | 11 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1 Jun 2010 |
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Keywords
- high altitude
- moderate altitude
- pulmonary arterial pressure
- pulmonary circulation
- pulmonary hypertension
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The impact of moderate-altitude staging on pulmonary arterial hemodynamics after ascent to high altitude. / Baggish, Aaron L.; Fulco, Charles S.; Muza, Stephen; Rock, Paul B.; Beidleman, Beth; Cymerman, Allen; Yared, Kibar; Fagenholz, Peter; Systrom, David; Wood, Malissa J.; Weyman, Arthur E.; Picard, Michael H.; Harris, N. Stuart.
In: High Altitude Medicine and Biology, Vol. 11, No. 2, 01.06.2010, p. 139-145.Research output: Contribution to journal › Article
TY - JOUR
T1 - The impact of moderate-altitude staging on pulmonary arterial hemodynamics after ascent to high altitude
AU - Baggish, Aaron L.
AU - Fulco, Charles S.
AU - Muza, Stephen
AU - Rock, Paul B.
AU - Beidleman, Beth
AU - Cymerman, Allen
AU - Yared, Kibar
AU - Fagenholz, Peter
AU - Systrom, David
AU - Wood, Malissa J.
AU - Weyman, Arthur E.
AU - Picard, Michael H.
AU - Harris, N. Stuart
PY - 2010/6/1
Y1 - 2010/6/1
N2 - Baggish, Aaron L., Charles S. Fulco, Stephen Muza, Paul B. Rock, Beth Beidleman, Allen Cymerman, Kibar Yared, Peter Fagenholz, David Systrom, Malissa J. Wood, Arthur E. Weyman, Michael H. Picard, and N. Stuart Harris The impact of moderate altitude on pulmonary arterial hemodynamics after ascent to high altitude. High Alt. Med. Biol. 11:139-145, 2010.-Staged ascent (SA), temporary residence at moderate altitude en route to high altitude, reduces the incidence and severity of noncardiopulmonary altitude illness such as acute mountain sickness. To date, the impact of SA on pulmonary arterial pressure (PAP) is unknown. We tested the hypothesis that SA would attenuate the PAP increase that occurs during rapid, direct ascent (DA). Transthoracic echocardiography was used to estimate mean PAP in 10 healthy males at sea level (SL, PB≈760 torr), after DA to simulated high altitude (hypobaric chamber, P B≈460 torr), and at 2 times points (90min and 4 days) during exposure to terrestrial high altitude (PB≈460 torr) after SA (7 days, moderate altitude, PB≈548 torr). Alveolar oxygen pressure (Pao2) and arterial oxygenation saturation (Sao2) were measured at each time point. Compared to mean PAP at SL (mean±SD, 14±3mmHg), mean PAP increased after DA to 37±8mmHg (Δ=24±10mmHg, p<0.001) and was negatively correlated with both Pao2 (r2=0.57, p=0.011) and Sao2 (r 2=0.64, p=0.005). In comparison, estimated mean PAP after SA increased to only 25±4mmHg (Δ=11±6mmHg, p<0.001), remained unchanged after 4 days of high altitude residence (24±5mmHg, p=not significant, or NS), and did not correlate with either parameter of oxygenation. SA significantly attenuated the PAP increase associated with continuous direct ascent to high altitude and appeared to uncouple PAP from both alveolar hypoxia and arterial hypoxemia.
AB - Baggish, Aaron L., Charles S. Fulco, Stephen Muza, Paul B. Rock, Beth Beidleman, Allen Cymerman, Kibar Yared, Peter Fagenholz, David Systrom, Malissa J. Wood, Arthur E. Weyman, Michael H. Picard, and N. Stuart Harris The impact of moderate altitude on pulmonary arterial hemodynamics after ascent to high altitude. High Alt. Med. Biol. 11:139-145, 2010.-Staged ascent (SA), temporary residence at moderate altitude en route to high altitude, reduces the incidence and severity of noncardiopulmonary altitude illness such as acute mountain sickness. To date, the impact of SA on pulmonary arterial pressure (PAP) is unknown. We tested the hypothesis that SA would attenuate the PAP increase that occurs during rapid, direct ascent (DA). Transthoracic echocardiography was used to estimate mean PAP in 10 healthy males at sea level (SL, PB≈760 torr), after DA to simulated high altitude (hypobaric chamber, P B≈460 torr), and at 2 times points (90min and 4 days) during exposure to terrestrial high altitude (PB≈460 torr) after SA (7 days, moderate altitude, PB≈548 torr). Alveolar oxygen pressure (Pao2) and arterial oxygenation saturation (Sao2) were measured at each time point. Compared to mean PAP at SL (mean±SD, 14±3mmHg), mean PAP increased after DA to 37±8mmHg (Δ=24±10mmHg, p<0.001) and was negatively correlated with both Pao2 (r2=0.57, p=0.011) and Sao2 (r 2=0.64, p=0.005). In comparison, estimated mean PAP after SA increased to only 25±4mmHg (Δ=11±6mmHg, p<0.001), remained unchanged after 4 days of high altitude residence (24±5mmHg, p=not significant, or NS), and did not correlate with either parameter of oxygenation. SA significantly attenuated the PAP increase associated with continuous direct ascent to high altitude and appeared to uncouple PAP from both alveolar hypoxia and arterial hypoxemia.
KW - high altitude
KW - moderate altitude
KW - pulmonary arterial pressure
KW - pulmonary circulation
KW - pulmonary hypertension
UR - http://www.scopus.com/inward/record.url?scp=77954901709&partnerID=8YFLogxK
U2 - 10.1089/ham.2009.1073
DO - 10.1089/ham.2009.1073
M3 - Article
C2 - 20586598
AN - SCOPUS:77954901709
VL - 11
SP - 139
EP - 145
JO - High Altitude Medicine and Biology
JF - High Altitude Medicine and Biology
SN - 1527-0297
IS - 2
ER -