The Chlamydomonas genome reveals the evolution of key animal and plant functions

Sabeeha S. Merchant, Simon E. Prochnik, Olivier Vallon, Elizabeth H. Harris, Steven J. Karpowicz, George B. Witman, Astrid Terry, Asaf Salamov, Lillian K. Fritz-Laylin, Laurence Maréchal-Drouard, Wallace F. Marshall, Liang Hu Qu, David R. Nelson, Anton A. Sanderfoot, Martin H. Spalding, Vladimir V. Kapitonov, Qinghu Ren, Patrick Ferris, Erika Lindquist, Harris ShapiroSusan M. Lucas, Jane Grimwood, Jeremy Schmutz, Igor V. Grigoriev, Daniel S. Rokhsar, Arthur R. Grossman, Pierre Cardol, Heriberto Cerutti, Guillaume Chanfreau, Chun Long Chen, Valérie Cognat, Martin T. Croft, Rachel Dent, Susan Dutcher, Emilio Fernández, Hideya Fukuzawa, David González-Ballester, Diego González-Halphen, Armin Hallmann, Marc Hanikenne, Michael Hippler, William Inwood, Kamel Jabbari, Ming Kalanon, Richard Kuras, Paul A. Lefebvre, Stéphane D. Lemaire, Alexey V. Lobanov, Martin Lohr, Andrea Manuell, Iris Meier, Laurens Mets, Maria Mittag, Telsa Mittelmeier, James V. Moroney, Jeffrey Moseley, Carolyn Napoli, Aurora M. Nedelcu, Krishna Niyogi, Sergey V. Novoselov, Ian T. Paulsen, Greg Pazour, Saul Purton, Jean Philippe Ral, Diego Mauricio Riaño-Pachón, Wayne Riekhof, Linda Rymarquis, Michael Schroda, David Stern, James Umen, Robert Willows, Nedra Wilson, Sara Lana Zimmer, Jens Allmer, Janneke Balk, Katerina Bisova, Chong Jian Chen, Marek Elias, Karla Gendler, Charles Hauser, Mary Rose Lamb, Heidi Ledford, Joanne C. Long, Jun Minagawa, M. Dudley Page, Junmin Pan, Wirulda Pootakham, Sanja Roje, Annkatrin Rose, Eric Stahlberg, Aimee M. Terauchi, Pinfen Yang, Steven Ball, Chris Bowler, Carol L. Dieckmann, Vadim N. Gladyshev, Pamela Green, Richard Jorgensen, Stephen Mayfield, Bernd Mueller-Roeber, Sathish Rajamani, Richard T. Sayre, Peter Brokstein, Inna Dubchak, David Goodstein, Leila Hornick, Y. Wayne Huang, Jinal Jhaveri, Yigong Luo, Diego Martínez, Wing Chi Abby Ngau, Bobby Otillar, Alexander Poliakov, Aaron Porter, Lukasz Szajkowski, Gregory Werner, Kemin Zhou

Research output: Contribution to journalArticle

1538 Citations (Scopus)

Abstract

Chlamydomonas reinhardtii is a unicellular green alga whose lineage diverged from land plants over 1 billion years ago. It is a model system for studying chloroplast-based photosynthesis, as well as the structure, assembly, and function of eukaryotic flagella (cilia), which were inherited from the common ancestor of plants and animals, but lost in land plants. We sequenced the ∼120-megabase nuclear genome of Chlamydomonas and performed comparative phylogenomic analyses, identifying genes encoding uncharacterized proteins that are likely associated with the function and biogenesis of chloroplasts or eukaryotic flagella. Analyses of the Chlamydomonas genome advance our understanding of the ancestral eukaryotic cell, reveal previously unknown genes associated with photosynthetic and flagellar functions, and establish links between ciliopathy and the composition and function of flagella.

Original languageEnglish
Pages (from-to)245-251
Number of pages7
JournalScience
Volume318
Issue number5848
DOIs
StatePublished - 12 Oct 2007

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Chlamydomonas
Flagella
Embryophyta
Genome
Chloroplasts
Chlamydomonas reinhardtii
Chlorophyta
Cilia
Photosynthesis
Eukaryotic Cells
Genes
Proteins

Cite this

Merchant, S. S., Prochnik, S. E., Vallon, O., Harris, E. H., Karpowicz, S. J., Witman, G. B., ... Zhou, K. (2007). The Chlamydomonas genome reveals the evolution of key animal and plant functions. Science, 318(5848), 245-251. https://doi.org/10.1126/science.1143609
Merchant, Sabeeha S. ; Prochnik, Simon E. ; Vallon, Olivier ; Harris, Elizabeth H. ; Karpowicz, Steven J. ; Witman, George B. ; Terry, Astrid ; Salamov, Asaf ; Fritz-Laylin, Lillian K. ; Maréchal-Drouard, Laurence ; Marshall, Wallace F. ; Qu, Liang Hu ; Nelson, David R. ; Sanderfoot, Anton A. ; Spalding, Martin H. ; Kapitonov, Vladimir V. ; Ren, Qinghu ; Ferris, Patrick ; Lindquist, Erika ; Shapiro, Harris ; Lucas, Susan M. ; Grimwood, Jane ; Schmutz, Jeremy ; Grigoriev, Igor V. ; Rokhsar, Daniel S. ; Grossman, Arthur R. ; Cardol, Pierre ; Cerutti, Heriberto ; Chanfreau, Guillaume ; Chen, Chun Long ; Cognat, Valérie ; Croft, Martin T. ; Dent, Rachel ; Dutcher, Susan ; Fernández, Emilio ; Fukuzawa, Hideya ; González-Ballester, David ; González-Halphen, Diego ; Hallmann, Armin ; Hanikenne, Marc ; Hippler, Michael ; Inwood, William ; Jabbari, Kamel ; Kalanon, Ming ; Kuras, Richard ; Lefebvre, Paul A. ; Lemaire, Stéphane D. ; Lobanov, Alexey V. ; Lohr, Martin ; Manuell, Andrea ; Meier, Iris ; Mets, Laurens ; Mittag, Maria ; Mittelmeier, Telsa ; Moroney, James V. ; Moseley, Jeffrey ; Napoli, Carolyn ; Nedelcu, Aurora M. ; Niyogi, Krishna ; Novoselov, Sergey V. ; Paulsen, Ian T. ; Pazour, Greg ; Purton, Saul ; Ral, Jean Philippe ; Riaño-Pachón, Diego Mauricio ; Riekhof, Wayne ; Rymarquis, Linda ; Schroda, Michael ; Stern, David ; Umen, James ; Willows, Robert ; Wilson, Nedra ; Zimmer, Sara Lana ; Allmer, Jens ; Balk, Janneke ; Bisova, Katerina ; Chen, Chong Jian ; Elias, Marek ; Gendler, Karla ; Hauser, Charles ; Lamb, Mary Rose ; Ledford, Heidi ; Long, Joanne C. ; Minagawa, Jun ; Page, M. Dudley ; Pan, Junmin ; Pootakham, Wirulda ; Roje, Sanja ; Rose, Annkatrin ; Stahlberg, Eric ; Terauchi, Aimee M. ; Yang, Pinfen ; Ball, Steven ; Bowler, Chris ; Dieckmann, Carol L. ; Gladyshev, Vadim N. ; Green, Pamela ; Jorgensen, Richard ; Mayfield, Stephen ; Mueller-Roeber, Bernd ; Rajamani, Sathish ; Sayre, Richard T. ; Brokstein, Peter ; Dubchak, Inna ; Goodstein, David ; Hornick, Leila ; Huang, Y. Wayne ; Jhaveri, Jinal ; Luo, Yigong ; Martínez, Diego ; Ngau, Wing Chi Abby ; Otillar, Bobby ; Poliakov, Alexander ; Porter, Aaron ; Szajkowski, Lukasz ; Werner, Gregory ; Zhou, Kemin. / The Chlamydomonas genome reveals the evolution of key animal and plant functions. In: Science. 2007 ; Vol. 318, No. 5848. pp. 245-251.
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abstract = "Chlamydomonas reinhardtii is a unicellular green alga whose lineage diverged from land plants over 1 billion years ago. It is a model system for studying chloroplast-based photosynthesis, as well as the structure, assembly, and function of eukaryotic flagella (cilia), which were inherited from the common ancestor of plants and animals, but lost in land plants. We sequenced the ∼120-megabase nuclear genome of Chlamydomonas and performed comparative phylogenomic analyses, identifying genes encoding uncharacterized proteins that are likely associated with the function and biogenesis of chloroplasts or eukaryotic flagella. Analyses of the Chlamydomonas genome advance our understanding of the ancestral eukaryotic cell, reveal previously unknown genes associated with photosynthetic and flagellar functions, and establish links between ciliopathy and the composition and function of flagella.",
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Merchant, SS, Prochnik, SE, Vallon, O, Harris, EH, Karpowicz, SJ, Witman, GB, Terry, A, Salamov, A, Fritz-Laylin, LK, Maréchal-Drouard, L, Marshall, WF, Qu, LH, Nelson, DR, Sanderfoot, AA, Spalding, MH, Kapitonov, VV, Ren, Q, Ferris, P, Lindquist, E, Shapiro, H, Lucas, SM, Grimwood, J, Schmutz, J, Grigoriev, IV, Rokhsar, DS, Grossman, AR, Cardol, P, Cerutti, H, Chanfreau, G, Chen, CL, Cognat, V, Croft, MT, Dent, R, Dutcher, S, Fernández, E, Fukuzawa, H, González-Ballester, D, González-Halphen, D, Hallmann, A, Hanikenne, M, Hippler, M, Inwood, W, Jabbari, K, Kalanon, M, Kuras, R, Lefebvre, PA, Lemaire, SD, Lobanov, AV, Lohr, M, Manuell, A, Meier, I, Mets, L, Mittag, M, Mittelmeier, T, Moroney, JV, Moseley, J, Napoli, C, Nedelcu, AM, Niyogi, K, Novoselov, SV, Paulsen, IT, Pazour, G, Purton, S, Ral, JP, Riaño-Pachón, DM, Riekhof, W, Rymarquis, L, Schroda, M, Stern, D, Umen, J, Willows, R, Wilson, N, Zimmer, SL, Allmer, J, Balk, J, Bisova, K, Chen, CJ, Elias, M, Gendler, K, Hauser, C, Lamb, MR, Ledford, H, Long, JC, Minagawa, J, Page, MD, Pan, J, Pootakham, W, Roje, S, Rose, A, Stahlberg, E, Terauchi, AM, Yang, P, Ball, S, Bowler, C, Dieckmann, CL, Gladyshev, VN, Green, P, Jorgensen, R, Mayfield, S, Mueller-Roeber, B, Rajamani, S, Sayre, RT, Brokstein, P, Dubchak, I, Goodstein, D, Hornick, L, Huang, YW, Jhaveri, J, Luo, Y, Martínez, D, Ngau, WCA, Otillar, B, Poliakov, A, Porter, A, Szajkowski, L, Werner, G & Zhou, K 2007, 'The Chlamydomonas genome reveals the evolution of key animal and plant functions', Science, vol. 318, no. 5848, pp. 245-251. https://doi.org/10.1126/science.1143609

The Chlamydomonas genome reveals the evolution of key animal and plant functions. / Merchant, Sabeeha S.; Prochnik, Simon E.; Vallon, Olivier; Harris, Elizabeth H.; Karpowicz, Steven J.; Witman, George B.; Terry, Astrid; Salamov, Asaf; Fritz-Laylin, Lillian K.; Maréchal-Drouard, Laurence; Marshall, Wallace F.; Qu, Liang Hu; Nelson, David R.; Sanderfoot, Anton A.; Spalding, Martin H.; Kapitonov, Vladimir V.; Ren, Qinghu; Ferris, Patrick; Lindquist, Erika; Shapiro, Harris; Lucas, Susan M.; Grimwood, Jane; Schmutz, Jeremy; Grigoriev, Igor V.; Rokhsar, Daniel S.; Grossman, Arthur R.; Cardol, Pierre; Cerutti, Heriberto; Chanfreau, Guillaume; Chen, Chun Long; Cognat, Valérie; Croft, Martin T.; Dent, Rachel; Dutcher, Susan; Fernández, Emilio; Fukuzawa, Hideya; González-Ballester, David; González-Halphen, Diego; Hallmann, Armin; Hanikenne, Marc; Hippler, Michael; Inwood, William; Jabbari, Kamel; Kalanon, Ming; Kuras, Richard; Lefebvre, Paul A.; Lemaire, Stéphane D.; Lobanov, Alexey V.; Lohr, Martin; Manuell, Andrea; Meier, Iris; Mets, Laurens; Mittag, Maria; Mittelmeier, Telsa; Moroney, James V.; Moseley, Jeffrey; Napoli, Carolyn; Nedelcu, Aurora M.; Niyogi, Krishna; Novoselov, Sergey V.; Paulsen, Ian T.; Pazour, Greg; Purton, Saul; Ral, Jean Philippe; Riaño-Pachón, Diego Mauricio; Riekhof, Wayne; Rymarquis, Linda; Schroda, Michael; Stern, David; Umen, James; Willows, Robert; Wilson, Nedra; Zimmer, Sara Lana; Allmer, Jens; Balk, Janneke; Bisova, Katerina; Chen, Chong Jian; Elias, Marek; Gendler, Karla; Hauser, Charles; Lamb, Mary Rose; Ledford, Heidi; Long, Joanne C.; Minagawa, Jun; Page, M. Dudley; Pan, Junmin; Pootakham, Wirulda; Roje, Sanja; Rose, Annkatrin; Stahlberg, Eric; Terauchi, Aimee M.; Yang, Pinfen; Ball, Steven; Bowler, Chris; Dieckmann, Carol L.; Gladyshev, Vadim N.; Green, Pamela; Jorgensen, Richard; Mayfield, Stephen; Mueller-Roeber, Bernd; Rajamani, Sathish; Sayre, Richard T.; Brokstein, Peter; Dubchak, Inna; Goodstein, David; Hornick, Leila; Huang, Y. Wayne; Jhaveri, Jinal; Luo, Yigong; Martínez, Diego; Ngau, Wing Chi Abby; Otillar, Bobby; Poliakov, Alexander; Porter, Aaron; Szajkowski, Lukasz; Werner, Gregory; Zhou, Kemin.

In: Science, Vol. 318, No. 5848, 12.10.2007, p. 245-251.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The Chlamydomonas genome reveals the evolution of key animal and plant functions

AU - Merchant, Sabeeha S.

AU - Prochnik, Simon E.

AU - Vallon, Olivier

AU - Harris, Elizabeth H.

AU - Karpowicz, Steven J.

AU - Witman, George B.

AU - Terry, Astrid

AU - Salamov, Asaf

AU - Fritz-Laylin, Lillian K.

AU - Maréchal-Drouard, Laurence

AU - Marshall, Wallace F.

AU - Qu, Liang Hu

AU - Nelson, David R.

AU - Sanderfoot, Anton A.

AU - Spalding, Martin H.

AU - Kapitonov, Vladimir V.

AU - Ren, Qinghu

AU - Ferris, Patrick

AU - Lindquist, Erika

AU - Shapiro, Harris

AU - Lucas, Susan M.

AU - Grimwood, Jane

AU - Schmutz, Jeremy

AU - Grigoriev, Igor V.

AU - Rokhsar, Daniel S.

AU - Grossman, Arthur R.

AU - Cardol, Pierre

AU - Cerutti, Heriberto

AU - Chanfreau, Guillaume

AU - Chen, Chun Long

AU - Cognat, Valérie

AU - Croft, Martin T.

AU - Dent, Rachel

AU - Dutcher, Susan

AU - Fernández, Emilio

AU - Fukuzawa, Hideya

AU - González-Ballester, David

AU - González-Halphen, Diego

AU - Hallmann, Armin

AU - Hanikenne, Marc

AU - Hippler, Michael

AU - Inwood, William

AU - Jabbari, Kamel

AU - Kalanon, Ming

AU - Kuras, Richard

AU - Lefebvre, Paul A.

AU - Lemaire, Stéphane D.

AU - Lobanov, Alexey V.

AU - Lohr, Martin

AU - Manuell, Andrea

AU - Meier, Iris

AU - Mets, Laurens

AU - Mittag, Maria

AU - Mittelmeier, Telsa

AU - Moroney, James V.

AU - Moseley, Jeffrey

AU - Napoli, Carolyn

AU - Nedelcu, Aurora M.

AU - Niyogi, Krishna

AU - Novoselov, Sergey V.

AU - Paulsen, Ian T.

AU - Pazour, Greg

AU - Purton, Saul

AU - Ral, Jean Philippe

AU - Riaño-Pachón, Diego Mauricio

AU - Riekhof, Wayne

AU - Rymarquis, Linda

AU - Schroda, Michael

AU - Stern, David

AU - Umen, James

AU - Willows, Robert

AU - Wilson, Nedra

AU - Zimmer, Sara Lana

AU - Allmer, Jens

AU - Balk, Janneke

AU - Bisova, Katerina

AU - Chen, Chong Jian

AU - Elias, Marek

AU - Gendler, Karla

AU - Hauser, Charles

AU - Lamb, Mary Rose

AU - Ledford, Heidi

AU - Long, Joanne C.

AU - Minagawa, Jun

AU - Page, M. Dudley

AU - Pan, Junmin

AU - Pootakham, Wirulda

AU - Roje, Sanja

AU - Rose, Annkatrin

AU - Stahlberg, Eric

AU - Terauchi, Aimee M.

AU - Yang, Pinfen

AU - Ball, Steven

AU - Bowler, Chris

AU - Dieckmann, Carol L.

AU - Gladyshev, Vadim N.

AU - Green, Pamela

AU - Jorgensen, Richard

AU - Mayfield, Stephen

AU - Mueller-Roeber, Bernd

AU - Rajamani, Sathish

AU - Sayre, Richard T.

AU - Brokstein, Peter

AU - Dubchak, Inna

AU - Goodstein, David

AU - Hornick, Leila

AU - Huang, Y. Wayne

AU - Jhaveri, Jinal

AU - Luo, Yigong

AU - Martínez, Diego

AU - Ngau, Wing Chi Abby

AU - Otillar, Bobby

AU - Poliakov, Alexander

AU - Porter, Aaron

AU - Szajkowski, Lukasz

AU - Werner, Gregory

AU - Zhou, Kemin

PY - 2007/10/12

Y1 - 2007/10/12

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AB - Chlamydomonas reinhardtii is a unicellular green alga whose lineage diverged from land plants over 1 billion years ago. It is a model system for studying chloroplast-based photosynthesis, as well as the structure, assembly, and function of eukaryotic flagella (cilia), which were inherited from the common ancestor of plants and animals, but lost in land plants. We sequenced the ∼120-megabase nuclear genome of Chlamydomonas and performed comparative phylogenomic analyses, identifying genes encoding uncharacterized proteins that are likely associated with the function and biogenesis of chloroplasts or eukaryotic flagella. Analyses of the Chlamydomonas genome advance our understanding of the ancestral eukaryotic cell, reveal previously unknown genes associated with photosynthetic and flagellar functions, and establish links between ciliopathy and the composition and function of flagella.

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U2 - 10.1126/science.1143609

DO - 10.1126/science.1143609

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C2 - 17932292

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VL - 318

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EP - 251

JO - Science

JF - Science

SN - 0036-8075

IS - 5848

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Merchant SS, Prochnik SE, Vallon O, Harris EH, Karpowicz SJ, Witman GB et al. The Chlamydomonas genome reveals the evolution of key animal and plant functions. Science. 2007 Oct 12;318(5848):245-251. https://doi.org/10.1126/science.1143609