Strawberries improve pain and inflammation in obese adults with radiographic evidence of knee osteoarthritis

Jace Schell, R. Hal Scofield, James R. Barrett, Biji T. Kurien, Nancy Betts, Timothy J. Lyons, Yan Daniel Zhao, Arpita Basu

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Osteoarthritis (OA), the most common form of arthritis, is a significant public health burden in U.S. adults. Among its many risk factors, obesity is a key player, causing inflammation, pain, impaired joint function, and reduced quality of life. Dietary polyphenols and other bioactive compounds in berries, curcumin, and tea have shown effects in ameliorating pain and inflammation in OA, but few clinical studies have been reported. The purpose of the present study was to examine the effects of dietary strawberries on pain, markers of inflammation, and quality of life indicators in obese adults with OA of the knee. In a randomized, double-blind cross-over trial, adults with radiographic evidence of knee OA (n = 17; body mass index (BMI): (mean ± SD) 39.1 ± 1.5; age (years): 57 ± 7) were randomized to a reconstituted freeze-dried strawberry beverage (50 g/day) or control beverage daily, each for 12 weeks, separated by a 2-week washout phase (total duration, 26 weeks). Blood draws and assessments of pain and quality of life indicators were conducted using the Visual Analog Scale for Pain (VAS Pain), Measures of Intermittent and Constant Osteoarthritis Pain (ICOAP), and Health Assessment Questionnaire-Disability Index (HAQ-DI) questionnaires, which were completed at baseline and at weeks 12, 14, and 26 of the study. Among the serum biomarkers of inflammation and cartilage degradation, interleukin (IL)-6, IL-1β, and matrix metalloproteinase (MMP)-3 were significantly decreased after strawberry vs. control treatment (all p < 0.05). Strawberry supplementation also significantly reduced constant, intermittent, and total pain as evaluated by the ICOAP questionnaire as well as the HAQ-DI scores (all p < 0.05). No effects of treatment were noted on serum C-reactive protein (CRP), nitrite, glucose, and lipid profiles. Dietary strawberries may have significant analgesic and anti-inflammatory effects in obese adults with established knee OA.

Original languageEnglish
Article number949
JournalNutrients
Volume9
Issue number9
DOIs
StatePublished - 1 Sep 2017
Externally publishedYes

Fingerprint

Fragaria
Knee Osteoarthritis
osteoarthritis
knees
strawberries
pain
Osteoarthritis
inflammation
Inflammation
Pain
Pain Measurement
questionnaires
Beverages
Quality of Life
quality of life
beverages
Matrix Metalloproteinase 3
Curcumin
Health
Arthralgia

Keywords

  • Inflammation
  • Knee osteoarthritis
  • Pain
  • Strawberries

Cite this

Schell, J., Hal Scofield, R., Barrett, J. R., Kurien, B. T., Betts, N., Lyons, T. J., ... Basu, A. (2017). Strawberries improve pain and inflammation in obese adults with radiographic evidence of knee osteoarthritis. Nutrients, 9(9), [949]. https://doi.org/10.3390/nu9090949
Schell, Jace ; Hal Scofield, R. ; Barrett, James R. ; Kurien, Biji T. ; Betts, Nancy ; Lyons, Timothy J. ; Zhao, Yan Daniel ; Basu, Arpita. / Strawberries improve pain and inflammation in obese adults with radiographic evidence of knee osteoarthritis. In: Nutrients. 2017 ; Vol. 9, No. 9.
@article{7de4d89c4ca443b6b54e9a20c468f9ca,
title = "Strawberries improve pain and inflammation in obese adults with radiographic evidence of knee osteoarthritis",
abstract = "Osteoarthritis (OA), the most common form of arthritis, is a significant public health burden in U.S. adults. Among its many risk factors, obesity is a key player, causing inflammation, pain, impaired joint function, and reduced quality of life. Dietary polyphenols and other bioactive compounds in berries, curcumin, and tea have shown effects in ameliorating pain and inflammation in OA, but few clinical studies have been reported. The purpose of the present study was to examine the effects of dietary strawberries on pain, markers of inflammation, and quality of life indicators in obese adults with OA of the knee. In a randomized, double-blind cross-over trial, adults with radiographic evidence of knee OA (n = 17; body mass index (BMI): (mean ± SD) 39.1 ± 1.5; age (years): 57 ± 7) were randomized to a reconstituted freeze-dried strawberry beverage (50 g/day) or control beverage daily, each for 12 weeks, separated by a 2-week washout phase (total duration, 26 weeks). Blood draws and assessments of pain and quality of life indicators were conducted using the Visual Analog Scale for Pain (VAS Pain), Measures of Intermittent and Constant Osteoarthritis Pain (ICOAP), and Health Assessment Questionnaire-Disability Index (HAQ-DI) questionnaires, which were completed at baseline and at weeks 12, 14, and 26 of the study. Among the serum biomarkers of inflammation and cartilage degradation, interleukin (IL)-6, IL-1β, and matrix metalloproteinase (MMP)-3 were significantly decreased after strawberry vs. control treatment (all p < 0.05). Strawberry supplementation also significantly reduced constant, intermittent, and total pain as evaluated by the ICOAP questionnaire as well as the HAQ-DI scores (all p < 0.05). No effects of treatment were noted on serum C-reactive protein (CRP), nitrite, glucose, and lipid profiles. Dietary strawberries may have significant analgesic and anti-inflammatory effects in obese adults with established knee OA.",
keywords = "Inflammation, Knee osteoarthritis, Pain, Strawberries",
author = "Jace Schell and {Hal Scofield}, R. and Barrett, {James R.} and Kurien, {Biji T.} and Nancy Betts and Lyons, {Timothy J.} and Zhao, {Yan Daniel} and Arpita Basu",
year = "2017",
month = "9",
day = "1",
doi = "10.3390/nu9090949",
language = "English",
volume = "9",
journal = "Nutrients",
issn = "2072-6643",
publisher = "Multidisciplinary Digital Publishing Institute",
number = "9",

}

Schell, J, Hal Scofield, R, Barrett, JR, Kurien, BT, Betts, N, Lyons, TJ, Zhao, YD & Basu, A 2017, 'Strawberries improve pain and inflammation in obese adults with radiographic evidence of knee osteoarthritis', Nutrients, vol. 9, no. 9, 949. https://doi.org/10.3390/nu9090949

Strawberries improve pain and inflammation in obese adults with radiographic evidence of knee osteoarthritis. / Schell, Jace; Hal Scofield, R.; Barrett, James R.; Kurien, Biji T.; Betts, Nancy; Lyons, Timothy J.; Zhao, Yan Daniel; Basu, Arpita.

In: Nutrients, Vol. 9, No. 9, 949, 01.09.2017.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Strawberries improve pain and inflammation in obese adults with radiographic evidence of knee osteoarthritis

AU - Schell, Jace

AU - Hal Scofield, R.

AU - Barrett, James R.

AU - Kurien, Biji T.

AU - Betts, Nancy

AU - Lyons, Timothy J.

AU - Zhao, Yan Daniel

AU - Basu, Arpita

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Osteoarthritis (OA), the most common form of arthritis, is a significant public health burden in U.S. adults. Among its many risk factors, obesity is a key player, causing inflammation, pain, impaired joint function, and reduced quality of life. Dietary polyphenols and other bioactive compounds in berries, curcumin, and tea have shown effects in ameliorating pain and inflammation in OA, but few clinical studies have been reported. The purpose of the present study was to examine the effects of dietary strawberries on pain, markers of inflammation, and quality of life indicators in obese adults with OA of the knee. In a randomized, double-blind cross-over trial, adults with radiographic evidence of knee OA (n = 17; body mass index (BMI): (mean ± SD) 39.1 ± 1.5; age (years): 57 ± 7) were randomized to a reconstituted freeze-dried strawberry beverage (50 g/day) or control beverage daily, each for 12 weeks, separated by a 2-week washout phase (total duration, 26 weeks). Blood draws and assessments of pain and quality of life indicators were conducted using the Visual Analog Scale for Pain (VAS Pain), Measures of Intermittent and Constant Osteoarthritis Pain (ICOAP), and Health Assessment Questionnaire-Disability Index (HAQ-DI) questionnaires, which were completed at baseline and at weeks 12, 14, and 26 of the study. Among the serum biomarkers of inflammation and cartilage degradation, interleukin (IL)-6, IL-1β, and matrix metalloproteinase (MMP)-3 were significantly decreased after strawberry vs. control treatment (all p < 0.05). Strawberry supplementation also significantly reduced constant, intermittent, and total pain as evaluated by the ICOAP questionnaire as well as the HAQ-DI scores (all p < 0.05). No effects of treatment were noted on serum C-reactive protein (CRP), nitrite, glucose, and lipid profiles. Dietary strawberries may have significant analgesic and anti-inflammatory effects in obese adults with established knee OA.

AB - Osteoarthritis (OA), the most common form of arthritis, is a significant public health burden in U.S. adults. Among its many risk factors, obesity is a key player, causing inflammation, pain, impaired joint function, and reduced quality of life. Dietary polyphenols and other bioactive compounds in berries, curcumin, and tea have shown effects in ameliorating pain and inflammation in OA, but few clinical studies have been reported. The purpose of the present study was to examine the effects of dietary strawberries on pain, markers of inflammation, and quality of life indicators in obese adults with OA of the knee. In a randomized, double-blind cross-over trial, adults with radiographic evidence of knee OA (n = 17; body mass index (BMI): (mean ± SD) 39.1 ± 1.5; age (years): 57 ± 7) were randomized to a reconstituted freeze-dried strawberry beverage (50 g/day) or control beverage daily, each for 12 weeks, separated by a 2-week washout phase (total duration, 26 weeks). Blood draws and assessments of pain and quality of life indicators were conducted using the Visual Analog Scale for Pain (VAS Pain), Measures of Intermittent and Constant Osteoarthritis Pain (ICOAP), and Health Assessment Questionnaire-Disability Index (HAQ-DI) questionnaires, which were completed at baseline and at weeks 12, 14, and 26 of the study. Among the serum biomarkers of inflammation and cartilage degradation, interleukin (IL)-6, IL-1β, and matrix metalloproteinase (MMP)-3 were significantly decreased after strawberry vs. control treatment (all p < 0.05). Strawberry supplementation also significantly reduced constant, intermittent, and total pain as evaluated by the ICOAP questionnaire as well as the HAQ-DI scores (all p < 0.05). No effects of treatment were noted on serum C-reactive protein (CRP), nitrite, glucose, and lipid profiles. Dietary strawberries may have significant analgesic and anti-inflammatory effects in obese adults with established knee OA.

KW - Inflammation

KW - Knee osteoarthritis

KW - Pain

KW - Strawberries

UR - http://www.scopus.com/inward/record.url?scp=85028549449&partnerID=8YFLogxK

U2 - 10.3390/nu9090949

DO - 10.3390/nu9090949

M3 - Article

C2 - 28846633

AN - SCOPUS:85028549449

VL - 9

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 9

M1 - 949

ER -