Spinal antinociceptive action of three representative opioid peptides in frogs

Craig W. Stevens, Paul D. Pezalla, Tony L. Yaksh

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Spinal administration of low doses of dynorphin, β-endorphin or Met-enkephalin produces a potent, dose-dependent increase in the nociceptive threshold in the unanesthetized frog, Rana pipiens. Nociceptive thresholds were determined by using the acetic acid test, previously shown to be a sensitive indicator of antinociception in this amphibian species. Of particular interest, spinally administered dynorphin produces a potent antinociception in frogs without any signs of motor dysfunction seen after spinally administered dynorphin in mammalian species.

Original languageEnglish
Pages (from-to)201-203
Number of pages3
JournalBrain Research
Issue number1
StatePublished - 27 Jan 1987


  • Amphibian
  • Antinociception
  • Dynorphin
  • Met-enkephalin
  • Rana pipiens
  • β-Endorphin


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