Abstract
Spinal administration of low doses of dynorphin, β-endorphin or Met-enkephalin produces a potent, dose-dependent increase in the nociceptive threshold in the unanesthetized frog, Rana pipiens. Nociceptive thresholds were determined by using the acetic acid test, previously shown to be a sensitive indicator of antinociception in this amphibian species. Of particular interest, spinally administered dynorphin produces a potent antinociception in frogs without any signs of motor dysfunction seen after spinally administered dynorphin in mammalian species.
Original language | English |
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Pages (from-to) | 201-203 |
Number of pages | 3 |
Journal | Brain Research |
Volume | 402 |
Issue number | 1 |
DOIs | |
State | Published - 27 Jan 1987 |
Keywords
- Amphibian
- Antinociception
- Dynorphin
- Met-enkephalin
- Rana pipiens
- β-Endorphin