Spinal administration of selective opioid antagonists in amphibians: Evidence for an opioid unireceptor

Craig Stevens, Leslie C. Newman

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

In mammals, opioids act by interactions with three distinct types of receptors: μ, δ, or κ opioid receptors. Using a novel assay of antinociception in the Northern grass frog, Rana pipiens, previous work demonstrated that selective μ, δ, or κ opioids produced a potent antinociception when administered by the spinal route. The relative potency of this effect was highly correlated to that found in mammals. Present studies employing selective opioid antagonists, β-FNA, NTI, or nor-BNI demonstrated that, in general, these antagonists were not selective in the amphibian model. These data have implications for the functional evolution of opioid receptors in vertebrates and suggest that the tested μ, δ, and κ opioids mediate antinociception via a single type of opioid receptor in amphibians, termed the unireceptor.

Original languageEnglish
JournalLife Sciences
Volume64
Issue number10
DOIs
StatePublished - 29 Jan 1999

Fingerprint

Narcotic Antagonists
Opioid Receptors
Amphibians
Opioid Analgesics
Mammals
Rana pipiens
Poaceae
Anura
Vertebrates
Assays

Keywords

  • Amphibian
  • Morphine
  • Opioid antinociception
  • Opioid receptor
  • Unireceptor

Cite this

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Spinal administration of selective opioid antagonists in amphibians : Evidence for an opioid unireceptor. / Stevens, Craig; Newman, Leslie C.

In: Life Sciences, Vol. 64, No. 10, 29.01.1999.

Research output: Contribution to journalArticle

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