Spinal action of dermorphin, an extremely potent opioid peptide from frog skin

Craig W. Stevens; Tony L. Yaksh

doi:10.1016/0006-8993(86)91076-0

Spinal action of dermorphin, an extremely potent opioid peptide from frog skin

Craig W. Stevens, Tony L. Yaksh

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Studies on the characteristics of spinally administered dermorphin, a novel heptapeptide isolated from the skin of South American Phyllomedusa frogs, indicated that this agent is 3-5000x more active than spinal morphine on the hot plate, tail flick and writhing tests. This agent displays naloxone reversibility and cross tolerance to spinal morphine, and possesses all of the characteristics of a μ opiate receptor agonist.

Original language	English
Pages (from-to)	300-304
Number of pages	5
Journal	Brain Research
Volume	385
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(86)91076-0
State	Published - 22 Oct 1986

Keywords

Amphibian
Analgesia
Dermorphin
Morphine
Tolerance

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@article{94bac9630f574204ab43930790543da6,

title = "Spinal action of dermorphin, an extremely potent opioid peptide from frog skin",

abstract = "Studies on the characteristics of spinally administered dermorphin, a novel heptapeptide isolated from the skin of South American Phyllomedusa frogs, indicated that this agent is 3-5000x more active than spinal morphine on the hot plate, tail flick and writhing tests. This agent displays naloxone reversibility and cross tolerance to spinal morphine, and possesses all of the characteristics of a μ opiate receptor agonist.",

keywords = "Amphibian, Analgesia, Dermorphin, Morphine, Tolerance",

author = "Stevens, {Craig W.} and Yaksh, {Tony L.}",

note = "Funding Information: We thank Ms. Vivian Mancini for critical comments, Ms. Ann Rockafellow for manuscript preparation and Ms. Gail Harty for technical assistance. This work was supported in part by funds from the Mayo Foundation and Grant DA-02110 (T.L.Y.).",

year = "1986",

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doi = "10.1016/0006-8993(86)91076-0",

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T1 - Spinal action of dermorphin, an extremely potent opioid peptide from frog skin

AU - Stevens, Craig W.

AU - Yaksh, Tony L.

N1 - Funding Information: We thank Ms. Vivian Mancini for critical comments, Ms. Ann Rockafellow for manuscript preparation and Ms. Gail Harty for technical assistance. This work was supported in part by funds from the Mayo Foundation and Grant DA-02110 (T.L.Y.).

PY - 1986/10/22

Y1 - 1986/10/22

N2 - Studies on the characteristics of spinally administered dermorphin, a novel heptapeptide isolated from the skin of South American Phyllomedusa frogs, indicated that this agent is 3-5000x more active than spinal morphine on the hot plate, tail flick and writhing tests. This agent displays naloxone reversibility and cross tolerance to spinal morphine, and possesses all of the characteristics of a μ opiate receptor agonist.

AB - Studies on the characteristics of spinally administered dermorphin, a novel heptapeptide isolated from the skin of South American Phyllomedusa frogs, indicated that this agent is 3-5000x more active than spinal morphine on the hot plate, tail flick and writhing tests. This agent displays naloxone reversibility and cross tolerance to spinal morphine, and possesses all of the characteristics of a μ opiate receptor agonist.

KW - Amphibian

KW - Analgesia

KW - Dermorphin

KW - Morphine

KW - Tolerance

UR - http://www.scopus.com/inward/record.url?scp=0022527022&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(86)91076-0

DO - 10.1016/0006-8993(86)91076-0

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AN - SCOPUS:0022527022

SN - 0006-8993

VL - 385

SP - 300

EP - 304

JO - Brain Research

JF - Brain Research

IS - 2

ER -

Spinal action of dermorphin, an extremely potent opioid peptide from frog skin

Abstract

Keywords

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