Spinal action of dermorphin, an extremely potent opioid peptide from frog skin

Craig W. Stevens, Tony L. Yaksh

Research output: Contribution to journalArticle

41 Scopus citations


Studies on the characteristics of spinally administered dermorphin, a novel heptapeptide isolated from the skin of South American Phyllomedusa frogs, indicated that this agent is 3-5000x more active than spinal morphine on the hot plate, tail flick and writhing tests. This agent displays naloxone reversibility and cross tolerance to spinal morphine, and possesses all of the characteristics of a μ opiate receptor agonist.

Original languageEnglish
Pages (from-to)300-304
Number of pages5
JournalBrain Research
Issue number2
Publication statusPublished - 22 Oct 1986



  • Amphibian
  • Analgesia
  • Dermorphin
  • Morphine
  • Tolerance

Cite this