Species differences in anxiety-related responses in male prairie and meadow voles: The effects of social isolation

Jennifer R. Stowe, Yan Liu, Tom Curtis, Marc E. Freeman, Zuoxin Wang

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Prairie (Microtus ochrogaster) and meadow voles (M. pennsylvanicus) are closely related species that differ in life strategy and social behaviors, and thus provide an excellent comparative model for the study of neuronal and hormonal mechanisms underlying behavior. In the present study using the elevated plus maze (EPM) test, we found that male prairie voles entered the open arms of the EPM more and remained there longer, and showed a higher level of overall locomotor activity than did male meadow voles. In addition, two weeks of social isolation induced an increase in open arm entries in prairie, but not meadow, voles. Prairie voles also had a higher level of circulating corticosterone compared to meadow voles, and the EPM test increased circulating corticosterone in prairie voles. Finally, social isolation coupled with the EPM test influenced Fos-immunoreactive expression in several brain areas, including the medial preoptic area, ventromedial hypothalamus, amygdala, and prefrontal cortex differently between the two species. Together, these data indicate a neural circuit involved in mediating anxiety-associated behavior in voles, and that the functioning of this circuit is influenced by social environment differently between social and non-social species.

Original languageEnglish
Pages (from-to)369-378
Number of pages10
JournalPhysiology and Behavior
Volume86
Issue number3
DOIs
StatePublished - 15 Oct 2005

Fingerprint

Social Isolation
Arvicolinae
Anxiety
Corticosterone
Grassland
Preoptic Area
Social Environment
Social Behavior
Locomotion
Amygdala
Prefrontal Cortex
Hypothalamus

Keywords

  • Amygdala
  • C-fos
  • Corticosterone
  • Elevated plus maze
  • MPOA
  • VMH

Cite this

Stowe, Jennifer R. ; Liu, Yan ; Curtis, Tom ; Freeman, Marc E. ; Wang, Zuoxin. / Species differences in anxiety-related responses in male prairie and meadow voles : The effects of social isolation. In: Physiology and Behavior. 2005 ; Vol. 86, No. 3. pp. 369-378.
@article{1d206d429adf424f89bb2e038a13e2a5,
title = "Species differences in anxiety-related responses in male prairie and meadow voles: The effects of social isolation",
abstract = "Prairie (Microtus ochrogaster) and meadow voles (M. pennsylvanicus) are closely related species that differ in life strategy and social behaviors, and thus provide an excellent comparative model for the study of neuronal and hormonal mechanisms underlying behavior. In the present study using the elevated plus maze (EPM) test, we found that male prairie voles entered the open arms of the EPM more and remained there longer, and showed a higher level of overall locomotor activity than did male meadow voles. In addition, two weeks of social isolation induced an increase in open arm entries in prairie, but not meadow, voles. Prairie voles also had a higher level of circulating corticosterone compared to meadow voles, and the EPM test increased circulating corticosterone in prairie voles. Finally, social isolation coupled with the EPM test influenced Fos-immunoreactive expression in several brain areas, including the medial preoptic area, ventromedial hypothalamus, amygdala, and prefrontal cortex differently between the two species. Together, these data indicate a neural circuit involved in mediating anxiety-associated behavior in voles, and that the functioning of this circuit is influenced by social environment differently between social and non-social species.",
keywords = "Amygdala, C-fos, Corticosterone, Elevated plus maze, MPOA, VMH",
author = "Stowe, {Jennifer R.} and Yan Liu and Tom Curtis and Freeman, {Marc E.} and Zuoxin Wang",
year = "2005",
month = "10",
day = "15",
doi = "10.1016/j.physbeh.2005.08.007",
language = "English",
volume = "86",
pages = "369--378",
journal = "Physiology and Behavior",
issn = "0031-9384",
publisher = "Elsevier Inc.",
number = "3",

}

Species differences in anxiety-related responses in male prairie and meadow voles : The effects of social isolation. / Stowe, Jennifer R.; Liu, Yan; Curtis, Tom; Freeman, Marc E.; Wang, Zuoxin.

In: Physiology and Behavior, Vol. 86, No. 3, 15.10.2005, p. 369-378.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Species differences in anxiety-related responses in male prairie and meadow voles

T2 - The effects of social isolation

AU - Stowe, Jennifer R.

AU - Liu, Yan

AU - Curtis, Tom

AU - Freeman, Marc E.

AU - Wang, Zuoxin

PY - 2005/10/15

Y1 - 2005/10/15

N2 - Prairie (Microtus ochrogaster) and meadow voles (M. pennsylvanicus) are closely related species that differ in life strategy and social behaviors, and thus provide an excellent comparative model for the study of neuronal and hormonal mechanisms underlying behavior. In the present study using the elevated plus maze (EPM) test, we found that male prairie voles entered the open arms of the EPM more and remained there longer, and showed a higher level of overall locomotor activity than did male meadow voles. In addition, two weeks of social isolation induced an increase in open arm entries in prairie, but not meadow, voles. Prairie voles also had a higher level of circulating corticosterone compared to meadow voles, and the EPM test increased circulating corticosterone in prairie voles. Finally, social isolation coupled with the EPM test influenced Fos-immunoreactive expression in several brain areas, including the medial preoptic area, ventromedial hypothalamus, amygdala, and prefrontal cortex differently between the two species. Together, these data indicate a neural circuit involved in mediating anxiety-associated behavior in voles, and that the functioning of this circuit is influenced by social environment differently between social and non-social species.

AB - Prairie (Microtus ochrogaster) and meadow voles (M. pennsylvanicus) are closely related species that differ in life strategy and social behaviors, and thus provide an excellent comparative model for the study of neuronal and hormonal mechanisms underlying behavior. In the present study using the elevated plus maze (EPM) test, we found that male prairie voles entered the open arms of the EPM more and remained there longer, and showed a higher level of overall locomotor activity than did male meadow voles. In addition, two weeks of social isolation induced an increase in open arm entries in prairie, but not meadow, voles. Prairie voles also had a higher level of circulating corticosterone compared to meadow voles, and the EPM test increased circulating corticosterone in prairie voles. Finally, social isolation coupled with the EPM test influenced Fos-immunoreactive expression in several brain areas, including the medial preoptic area, ventromedial hypothalamus, amygdala, and prefrontal cortex differently between the two species. Together, these data indicate a neural circuit involved in mediating anxiety-associated behavior in voles, and that the functioning of this circuit is influenced by social environment differently between social and non-social species.

KW - Amygdala

KW - C-fos

KW - Corticosterone

KW - Elevated plus maze

KW - MPOA

KW - VMH

UR - http://www.scopus.com/inward/record.url?scp=26944484012&partnerID=8YFLogxK

U2 - 10.1016/j.physbeh.2005.08.007

DO - 10.1016/j.physbeh.2005.08.007

M3 - Article

C2 - 16115657

AN - SCOPUS:26944484012

VL - 86

SP - 369

EP - 378

JO - Physiology and Behavior

JF - Physiology and Behavior

SN - 0031-9384

IS - 3

ER -