Social bonding decreases the rewarding properties of amphetamine through a dopamine D1 receptor-mediated mechanism

Yan Liu, Kimberly A. Young, Tom Curtis, Brandon J. Aragona, Zuoxin Wang

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Although the protective effects of social bonds on drug use/abuse have been well documented, we know little about the underlying neural mechanisms. Using the prairie vole (Microtus ochrogaster)-a socially monogamous rodent that forms long-term pair bonds after mating-we demonstrate that amphetamine (AMPH) conditioning induced a conditioned place preference (CPP) in sexually naive (SN), but not pair-bonded (PB), males. AlthoughAMPHtreatment induced a similar magnitude of dopamine release in the nucleus accumbens (NAcc) of SN and PB males, it had differential effects on NAcc D1 receptor (D1R) binding. Specifically, AMPH treatment increased D1R binding in SN, but decreased D1R binding in PB males. NAcc D1R, but not D2 receptor, antagonism blocked AMPH-induced CPP in SN males and NAcc D1R activation before AMPH conditioning enabled AMPH-induced CPP in PB males. Together, our data demonstrate that pair-bonding experience decreases the rewarding properties of AMPH through a D1R-mediated mechanism.

Original languageEnglish
Pages (from-to)7960-7966
Number of pages7
JournalJournal of Neuroscience
Volume31
Issue number22
DOIs
StatePublished - 1 Jun 2011

Fingerprint

Dopamine D1 Receptors
Amphetamine
Nucleus Accumbens
Arvicolinae
Pair Bond
Substance-Related Disorders
Object Attachment
Rodentia
Dopamine

Cite this

Liu, Yan ; Young, Kimberly A. ; Curtis, Tom ; Aragona, Brandon J. ; Wang, Zuoxin. / Social bonding decreases the rewarding properties of amphetamine through a dopamine D1 receptor-mediated mechanism. In: Journal of Neuroscience. 2011 ; Vol. 31, No. 22. pp. 7960-7966.
@article{bbd668a38e854c6aa1f8b00c4c0cfbdf,
title = "Social bonding decreases the rewarding properties of amphetamine through a dopamine D1 receptor-mediated mechanism",
abstract = "Although the protective effects of social bonds on drug use/abuse have been well documented, we know little about the underlying neural mechanisms. Using the prairie vole (Microtus ochrogaster)-a socially monogamous rodent that forms long-term pair bonds after mating-we demonstrate that amphetamine (AMPH) conditioning induced a conditioned place preference (CPP) in sexually naive (SN), but not pair-bonded (PB), males. AlthoughAMPHtreatment induced a similar magnitude of dopamine release in the nucleus accumbens (NAcc) of SN and PB males, it had differential effects on NAcc D1 receptor (D1R) binding. Specifically, AMPH treatment increased D1R binding in SN, but decreased D1R binding in PB males. NAcc D1R, but not D2 receptor, antagonism blocked AMPH-induced CPP in SN males and NAcc D1R activation before AMPH conditioning enabled AMPH-induced CPP in PB males. Together, our data demonstrate that pair-bonding experience decreases the rewarding properties of AMPH through a D1R-mediated mechanism.",
author = "Yan Liu and Young, {Kimberly A.} and Tom Curtis and Aragona, {Brandon J.} and Zuoxin Wang",
year = "2011",
month = "6",
day = "1",
doi = "10.1523/JNEUROSCI.1006-11.2011",
language = "English",
volume = "31",
pages = "7960--7966",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "22",

}

Social bonding decreases the rewarding properties of amphetamine through a dopamine D1 receptor-mediated mechanism. / Liu, Yan; Young, Kimberly A.; Curtis, Tom; Aragona, Brandon J.; Wang, Zuoxin.

In: Journal of Neuroscience, Vol. 31, No. 22, 01.06.2011, p. 7960-7966.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Social bonding decreases the rewarding properties of amphetamine through a dopamine D1 receptor-mediated mechanism

AU - Liu, Yan

AU - Young, Kimberly A.

AU - Curtis, Tom

AU - Aragona, Brandon J.

AU - Wang, Zuoxin

PY - 2011/6/1

Y1 - 2011/6/1

N2 - Although the protective effects of social bonds on drug use/abuse have been well documented, we know little about the underlying neural mechanisms. Using the prairie vole (Microtus ochrogaster)-a socially monogamous rodent that forms long-term pair bonds after mating-we demonstrate that amphetamine (AMPH) conditioning induced a conditioned place preference (CPP) in sexually naive (SN), but not pair-bonded (PB), males. AlthoughAMPHtreatment induced a similar magnitude of dopamine release in the nucleus accumbens (NAcc) of SN and PB males, it had differential effects on NAcc D1 receptor (D1R) binding. Specifically, AMPH treatment increased D1R binding in SN, but decreased D1R binding in PB males. NAcc D1R, but not D2 receptor, antagonism blocked AMPH-induced CPP in SN males and NAcc D1R activation before AMPH conditioning enabled AMPH-induced CPP in PB males. Together, our data demonstrate that pair-bonding experience decreases the rewarding properties of AMPH through a D1R-mediated mechanism.

AB - Although the protective effects of social bonds on drug use/abuse have been well documented, we know little about the underlying neural mechanisms. Using the prairie vole (Microtus ochrogaster)-a socially monogamous rodent that forms long-term pair bonds after mating-we demonstrate that amphetamine (AMPH) conditioning induced a conditioned place preference (CPP) in sexually naive (SN), but not pair-bonded (PB), males. AlthoughAMPHtreatment induced a similar magnitude of dopamine release in the nucleus accumbens (NAcc) of SN and PB males, it had differential effects on NAcc D1 receptor (D1R) binding. Specifically, AMPH treatment increased D1R binding in SN, but decreased D1R binding in PB males. NAcc D1R, but not D2 receptor, antagonism blocked AMPH-induced CPP in SN males and NAcc D1R activation before AMPH conditioning enabled AMPH-induced CPP in PB males. Together, our data demonstrate that pair-bonding experience decreases the rewarding properties of AMPH through a D1R-mediated mechanism.

UR - http://www.scopus.com/inward/record.url?scp=79958289818&partnerID=8YFLogxK

U2 - 10.1523/JNEUROSCI.1006-11.2011

DO - 10.1523/JNEUROSCI.1006-11.2011

M3 - Article

C2 - 21632917

AN - SCOPUS:79958289818

VL - 31

SP - 7960

EP - 7966

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 22

ER -