Sleep at simulated 2438 m: Effects on oxygenation, sleep quality, and postsleep performance

J. Michael Muhm, T. Leigh Signal, Paul B. Rock, Stephen P. Jones, Karyn M. O'Keeffe, Matthew R. Weaver, Shuying Zhu, Philippa H. Gander, Greg Belenky

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Introduction: Crewmembers on ultra long-range commercial flights have the opportunity for rest and sleep in onboard areas in which the barometric pressure is 75.3 kPa (565 mmHg) or higher, equivalent to a terrestrial altitude of 2438 m (8000 ft) or lower. Sleep at higher altitudes is known to be disturbed, resulting in postsleep neurobehavioral performance decrements. We investigated the effects of sleep at 2438 m on oxygen saturation, heart rate, sleep quantity, sleep quality, postsleep neurobehavioral performance, and mood. Methods: Twenty men, 30-56 yr of age, participated in a blinded cross-over investigation conducted in a hypobaric chamber to compare the effects of sleep at altitude (ALT, 2438 m) and ground level (GND, 305 m). Results: SpO2 measured before sleep was significantly lower at ALT than at GND, 90.7 ± 2.0% (average ± SD) and 96.2 ± 2.0%, respectively. During sleep, SpO2 decreased further to 86.1 ± 2.0% at ALT, and 92.3% ± 2.0% at GND. The percent of time during which SpO2 was below 90% was 44.4% (3.6-86.9%) at ALT and 0.1% (0.0-22.9%) at GND. Objective and subjective measurements of sleep quantity and quality did not differ significantly with altitude, nor did postsleep neurobehavioral performance or mood. Discussion: The absence of significant changes in sleep and postsleep neurobehavioral performance associated with pronounced oxygen desaturation during sleep was unexpected. Further study is needed to determine if the same effects occur in women and to characterize the changes in respiratory physiology that occur during sleep at 2438 m in both sexes.

Original languageEnglish
Pages (from-to)691-697
Number of pages7
JournalAviation Space and Environmental Medicine
Volume80
Issue number8
DOIs
StatePublished - 1 Aug 2009

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Sleep
Respiratory Physiological Phenomena
Oxygen
Heart Rate
Pressure

Keywords

  • Altitude
  • Automated neuropsychological assessment metrics
  • Commercial airplane
  • Hypoxia
  • Polysomnography
  • Psychomotor vigilance test
  • Respiratory disturbance
  • Sleep quality
  • Sleep quantity

Cite this

Muhm, J. Michael ; Signal, T. Leigh ; Rock, Paul B. ; Jones, Stephen P. ; O'Keeffe, Karyn M. ; Weaver, Matthew R. ; Zhu, Shuying ; Gander, Philippa H. ; Belenky, Greg. / Sleep at simulated 2438 m : Effects on oxygenation, sleep quality, and postsleep performance. In: Aviation Space and Environmental Medicine. 2009 ; Vol. 80, No. 8. pp. 691-697.
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title = "Sleep at simulated 2438 m: Effects on oxygenation, sleep quality, and postsleep performance",
abstract = "Introduction: Crewmembers on ultra long-range commercial flights have the opportunity for rest and sleep in onboard areas in which the barometric pressure is 75.3 kPa (565 mmHg) or higher, equivalent to a terrestrial altitude of 2438 m (8000 ft) or lower. Sleep at higher altitudes is known to be disturbed, resulting in postsleep neurobehavioral performance decrements. We investigated the effects of sleep at 2438 m on oxygen saturation, heart rate, sleep quantity, sleep quality, postsleep neurobehavioral performance, and mood. Methods: Twenty men, 30-56 yr of age, participated in a blinded cross-over investigation conducted in a hypobaric chamber to compare the effects of sleep at altitude (ALT, 2438 m) and ground level (GND, 305 m). Results: SpO2 measured before sleep was significantly lower at ALT than at GND, 90.7 ± 2.0{\%} (average ± SD) and 96.2 ± 2.0{\%}, respectively. During sleep, SpO2 decreased further to 86.1 ± 2.0{\%} at ALT, and 92.3{\%} ± 2.0{\%} at GND. The percent of time during which SpO2 was below 90{\%} was 44.4{\%} (3.6-86.9{\%}) at ALT and 0.1{\%} (0.0-22.9{\%}) at GND. Objective and subjective measurements of sleep quantity and quality did not differ significantly with altitude, nor did postsleep neurobehavioral performance or mood. Discussion: The absence of significant changes in sleep and postsleep neurobehavioral performance associated with pronounced oxygen desaturation during sleep was unexpected. Further study is needed to determine if the same effects occur in women and to characterize the changes in respiratory physiology that occur during sleep at 2438 m in both sexes.",
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Muhm, JM, Signal, TL, Rock, PB, Jones, SP, O'Keeffe, KM, Weaver, MR, Zhu, S, Gander, PH & Belenky, G 2009, 'Sleep at simulated 2438 m: Effects on oxygenation, sleep quality, and postsleep performance', Aviation Space and Environmental Medicine, vol. 80, no. 8, pp. 691-697. https://doi.org/10.3357/ASEM.2327.2009

Sleep at simulated 2438 m : Effects on oxygenation, sleep quality, and postsleep performance. / Muhm, J. Michael; Signal, T. Leigh; Rock, Paul B.; Jones, Stephen P.; O'Keeffe, Karyn M.; Weaver, Matthew R.; Zhu, Shuying; Gander, Philippa H.; Belenky, Greg.

In: Aviation Space and Environmental Medicine, Vol. 80, No. 8, 01.08.2009, p. 691-697.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Sleep at simulated 2438 m

T2 - Effects on oxygenation, sleep quality, and postsleep performance

AU - Muhm, J. Michael

AU - Signal, T. Leigh

AU - Rock, Paul B.

AU - Jones, Stephen P.

AU - O'Keeffe, Karyn M.

AU - Weaver, Matthew R.

AU - Zhu, Shuying

AU - Gander, Philippa H.

AU - Belenky, Greg

PY - 2009/8/1

Y1 - 2009/8/1

N2 - Introduction: Crewmembers on ultra long-range commercial flights have the opportunity for rest and sleep in onboard areas in which the barometric pressure is 75.3 kPa (565 mmHg) or higher, equivalent to a terrestrial altitude of 2438 m (8000 ft) or lower. Sleep at higher altitudes is known to be disturbed, resulting in postsleep neurobehavioral performance decrements. We investigated the effects of sleep at 2438 m on oxygen saturation, heart rate, sleep quantity, sleep quality, postsleep neurobehavioral performance, and mood. Methods: Twenty men, 30-56 yr of age, participated in a blinded cross-over investigation conducted in a hypobaric chamber to compare the effects of sleep at altitude (ALT, 2438 m) and ground level (GND, 305 m). Results: SpO2 measured before sleep was significantly lower at ALT than at GND, 90.7 ± 2.0% (average ± SD) and 96.2 ± 2.0%, respectively. During sleep, SpO2 decreased further to 86.1 ± 2.0% at ALT, and 92.3% ± 2.0% at GND. The percent of time during which SpO2 was below 90% was 44.4% (3.6-86.9%) at ALT and 0.1% (0.0-22.9%) at GND. Objective and subjective measurements of sleep quantity and quality did not differ significantly with altitude, nor did postsleep neurobehavioral performance or mood. Discussion: The absence of significant changes in sleep and postsleep neurobehavioral performance associated with pronounced oxygen desaturation during sleep was unexpected. Further study is needed to determine if the same effects occur in women and to characterize the changes in respiratory physiology that occur during sleep at 2438 m in both sexes.

AB - Introduction: Crewmembers on ultra long-range commercial flights have the opportunity for rest and sleep in onboard areas in which the barometric pressure is 75.3 kPa (565 mmHg) or higher, equivalent to a terrestrial altitude of 2438 m (8000 ft) or lower. Sleep at higher altitudes is known to be disturbed, resulting in postsleep neurobehavioral performance decrements. We investigated the effects of sleep at 2438 m on oxygen saturation, heart rate, sleep quantity, sleep quality, postsleep neurobehavioral performance, and mood. Methods: Twenty men, 30-56 yr of age, participated in a blinded cross-over investigation conducted in a hypobaric chamber to compare the effects of sleep at altitude (ALT, 2438 m) and ground level (GND, 305 m). Results: SpO2 measured before sleep was significantly lower at ALT than at GND, 90.7 ± 2.0% (average ± SD) and 96.2 ± 2.0%, respectively. During sleep, SpO2 decreased further to 86.1 ± 2.0% at ALT, and 92.3% ± 2.0% at GND. The percent of time during which SpO2 was below 90% was 44.4% (3.6-86.9%) at ALT and 0.1% (0.0-22.9%) at GND. Objective and subjective measurements of sleep quantity and quality did not differ significantly with altitude, nor did postsleep neurobehavioral performance or mood. Discussion: The absence of significant changes in sleep and postsleep neurobehavioral performance associated with pronounced oxygen desaturation during sleep was unexpected. Further study is needed to determine if the same effects occur in women and to characterize the changes in respiratory physiology that occur during sleep at 2438 m in both sexes.

KW - Altitude

KW - Automated neuropsychological assessment metrics

KW - Commercial airplane

KW - Hypoxia

KW - Polysomnography

KW - Psychomotor vigilance test

KW - Respiratory disturbance

KW - Sleep quality

KW - Sleep quantity

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