TY - JOUR
T1 - Simian foamy virus infections in a baboon breeding colony
AU - Blewett, Earl L.
AU - Black, Darla H.
AU - Lerche, Nicholas W.
AU - White, Gary
AU - Eberle, R.
N1 - Funding Information:
We thank William H. Switzer, Centers for Disease Control and Prevention, (Atlanta, GA) for generously providing SFV-3 (agm), and JoAnn Yee of the CRPRC for excellent technical assistance. Primers were synthesized and DNA sequencing was performed at the Oklahoma State University Core Facility. This study was supported in part by Grants P40 RR12317 (OUHSC), R01 RR07849 (OSU CVM), R01 R13129 (OSU OCOM), and RR00169 (CRPRC) from the National Center for Research Resources, National Institutes of Health.
PY - 2000/12/5
Y1 - 2000/12/5
N2 - The prevalence, transmission, and variation of simian foamy viruses (SFVs) in baboons was investigated. Over 95% of adult baboons in the breeding colony as well as recently imported adult animals had high titers of anti-SFV serum IgG. Maternal antibody was detectable in infants' serum up to 6 months of age. Approximately 30% of infants in breeding harems experienced SFV infections by 1 year of age. Shedding of SFV in oral secretions was common, with 13% of samples from normal adult animals and 35% from immunosuppressed animals containing infectious SFV. SFV was isolated from three baboon subspecies (olive, yellow, and chacma baboons) and sequences from both the pol and the LTR regions of the provirus were amplified by PCR and sequenced. Phylogenetic analysis indicated that all baboon isolates formed a single lineage distinct from SFVs of other African monkey species. Within the baboon SFV lineage, two distinct clades were apparent, which consisted of isolates from yellow and olive baboons and isolates from chacma baboons. Competition ELISAs indicated that, while SFV isolates of these two groups were very closely related, antigenic differences do exist between them. SFV isolates from a drill and a mandrill were distinct from baboon SFV isolates, both genetically and antigenically. (C) 2000 Academic Press.
AB - The prevalence, transmission, and variation of simian foamy viruses (SFVs) in baboons was investigated. Over 95% of adult baboons in the breeding colony as well as recently imported adult animals had high titers of anti-SFV serum IgG. Maternal antibody was detectable in infants' serum up to 6 months of age. Approximately 30% of infants in breeding harems experienced SFV infections by 1 year of age. Shedding of SFV in oral secretions was common, with 13% of samples from normal adult animals and 35% from immunosuppressed animals containing infectious SFV. SFV was isolated from three baboon subspecies (olive, yellow, and chacma baboons) and sequences from both the pol and the LTR regions of the provirus were amplified by PCR and sequenced. Phylogenetic analysis indicated that all baboon isolates formed a single lineage distinct from SFVs of other African monkey species. Within the baboon SFV lineage, two distinct clades were apparent, which consisted of isolates from yellow and olive baboons and isolates from chacma baboons. Competition ELISAs indicated that, while SFV isolates of these two groups were very closely related, antigenic differences do exist between them. SFV isolates from a drill and a mandrill were distinct from baboon SFV isolates, both genetically and antigenically. (C) 2000 Academic Press.
UR - http://www.scopus.com/inward/record.url?scp=0034610228&partnerID=8YFLogxK
U2 - 10.1006/viro.2000.0649
DO - 10.1006/viro.2000.0649
M3 - Article
C2 - 11112493
AN - SCOPUS:0034610228
VL - 278
SP - 183
EP - 193
JO - Virology
JF - Virology
SN - 0042-6822
IS - 1
ER -