Self-reported executive dysfunction, neuropsychological impairment, and functional outcomes in multiple sclerosis

Michael R. Basso, Isaac S. Shields, Natasha Lowery, Courtney Ghormley, Dennis Combs, Peter A. Arnett, Jay Johnson

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Although cognitive deficits are common in persons with multiple sclerosis (MS), the relationship between subjective complaints and objective impairment is sometimes obscured. To elaborate this issue, the present study examined the relationship between subjective complaints of dysexecutive syndrome, neuropsychological performance, and self-reported activities of daily living in 42 people with MS and 13 control participants. Regression analyses revealed that subjective complaints of impairment, measured by the Frontal Systems Behavior Scale (FrSBe), emerged as a significant predictor of neuropsychological deficit and poor adaptive function. Accordingly, subjective complaints of dysexecutive function in MS may serve as a potent indicator of cognitive and functional impairment. Implications for research and clinical practice are discussed.

Original languageEnglish
Pages (from-to)920-930
Number of pages11
JournalJournal of Clinical and Experimental Neuropsychology
Volume30
Issue number8
DOIs
StatePublished - 1 Apr 2008

Fingerprint

Multiple Sclerosis
Activities of Daily Living
Regression Analysis
Research
Cognitive Dysfunction

Keywords

  • Disability
  • Dysexecutive syndrome
  • Executive function
  • Functional outcomes
  • Multiple sclerosis

Cite this

Basso, Michael R. ; Shields, Isaac S. ; Lowery, Natasha ; Ghormley, Courtney ; Combs, Dennis ; Arnett, Peter A. ; Johnson, Jay. / Self-reported executive dysfunction, neuropsychological impairment, and functional outcomes in multiple sclerosis. In: Journal of Clinical and Experimental Neuropsychology. 2008 ; Vol. 30, No. 8. pp. 920-930.
@article{7b627eadb36243e18790cc47e9e3adb5,
title = "Self-reported executive dysfunction, neuropsychological impairment, and functional outcomes in multiple sclerosis",
abstract = "Although cognitive deficits are common in persons with multiple sclerosis (MS), the relationship between subjective complaints and objective impairment is sometimes obscured. To elaborate this issue, the present study examined the relationship between subjective complaints of dysexecutive syndrome, neuropsychological performance, and self-reported activities of daily living in 42 people with MS and 13 control participants. Regression analyses revealed that subjective complaints of impairment, measured by the Frontal Systems Behavior Scale (FrSBe), emerged as a significant predictor of neuropsychological deficit and poor adaptive function. Accordingly, subjective complaints of dysexecutive function in MS may serve as a potent indicator of cognitive and functional impairment. Implications for research and clinical practice are discussed.",
keywords = "Disability, Dysexecutive syndrome, Executive function, Functional outcomes, Multiple sclerosis",
author = "Basso, {Michael R.} and Shields, {Isaac S.} and Natasha Lowery and Courtney Ghormley and Dennis Combs and Arnett, {Peter A.} and Jay Johnson",
year = "2008",
month = "4",
day = "1",
doi = "10.1080/13803390801888733",
language = "English",
volume = "30",
pages = "920--930",
journal = "Journal of Clinical and Experimental Neuropsychology",
issn = "1380-3395",
publisher = "Taylor and Francis Ltd.",
number = "8",

}

Self-reported executive dysfunction, neuropsychological impairment, and functional outcomes in multiple sclerosis. / Basso, Michael R.; Shields, Isaac S.; Lowery, Natasha; Ghormley, Courtney; Combs, Dennis; Arnett, Peter A.; Johnson, Jay.

In: Journal of Clinical and Experimental Neuropsychology, Vol. 30, No. 8, 01.04.2008, p. 920-930.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Self-reported executive dysfunction, neuropsychological impairment, and functional outcomes in multiple sclerosis

AU - Basso, Michael R.

AU - Shields, Isaac S.

AU - Lowery, Natasha

AU - Ghormley, Courtney

AU - Combs, Dennis

AU - Arnett, Peter A.

AU - Johnson, Jay

PY - 2008/4/1

Y1 - 2008/4/1

N2 - Although cognitive deficits are common in persons with multiple sclerosis (MS), the relationship between subjective complaints and objective impairment is sometimes obscured. To elaborate this issue, the present study examined the relationship between subjective complaints of dysexecutive syndrome, neuropsychological performance, and self-reported activities of daily living in 42 people with MS and 13 control participants. Regression analyses revealed that subjective complaints of impairment, measured by the Frontal Systems Behavior Scale (FrSBe), emerged as a significant predictor of neuropsychological deficit and poor adaptive function. Accordingly, subjective complaints of dysexecutive function in MS may serve as a potent indicator of cognitive and functional impairment. Implications for research and clinical practice are discussed.

AB - Although cognitive deficits are common in persons with multiple sclerosis (MS), the relationship between subjective complaints and objective impairment is sometimes obscured. To elaborate this issue, the present study examined the relationship between subjective complaints of dysexecutive syndrome, neuropsychological performance, and self-reported activities of daily living in 42 people with MS and 13 control participants. Regression analyses revealed that subjective complaints of impairment, measured by the Frontal Systems Behavior Scale (FrSBe), emerged as a significant predictor of neuropsychological deficit and poor adaptive function. Accordingly, subjective complaints of dysexecutive function in MS may serve as a potent indicator of cognitive and functional impairment. Implications for research and clinical practice are discussed.

KW - Disability

KW - Dysexecutive syndrome

KW - Executive function

KW - Functional outcomes

KW - Multiple sclerosis

UR - http://www.scopus.com/inward/record.url?scp=54349127867&partnerID=8YFLogxK

U2 - 10.1080/13803390801888733

DO - 10.1080/13803390801888733

M3 - Article

C2 - 18608679

AN - SCOPUS:54349127867

VL - 30

SP - 920

EP - 930

JO - Journal of Clinical and Experimental Neuropsychology

JF - Journal of Clinical and Experimental Neuropsychology

SN - 1380-3395

IS - 8

ER -