Role of the Kv4.3 K+ channel in ventricular muscle: A molecular correlate for the transient outward current

Jane E. Dixon, Wenmei Shi, Hong Sheng Wang, Christine McDonald, Hangang Yu, Randy Wymore, Ira S. Cohen, David McKinnon

Research output: Contribution to journalArticle

373 Citations (Scopus)

Abstract

The expression of 15 different K+ channels in canine heart was examined, and a new K+ channel gene (Kv4.3), which encodes a rapidly inactivating K+ current, is described. The Kv4.3 channel was found to have biophysical and pharmacological properties similar to the native canine transient outward current (I(to)). The Kv4.3 gene is also expressed in human and rat heart. It is concluded that the Kv4.3 channel underlies the bulk of the I(to) in canine ventricular myocytes, and probably in human myocytes. Both the Kv4.3 and Kv4.2 channels are likely to contribute to the I(to) in rat heart, and differential expression of these two channels can account for observed differences in the kinetic properties of the I(to), in different regions of rat ventricle. There are significant differences in the pattern of K+ channel expression in canine heart, compared with rat heart, and these differences may be an adaptation to the different requirements for cardiac function in mammals of markedly different sizes. It is possible that the much longer ventricular action potential duration observed in canine heart compared with rat heart is due, in part, to the lower levels of Kv1.2, Kv2.1, and Kv4.2 gene expression in canine heart.

Original languageEnglish
Pages (from-to)659-668
Number of pages10
JournalCirculation Research
Volume79
Issue number4
DOIs
StatePublished - 1 Jan 1996

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Canidae
Muscles
Muscle Cells
Genes
Action Potentials
Mammals
Pharmacology
Gene Expression

Keywords

  • K channel
  • cardiac muscle
  • mRNA expression
  • transient outward current

Cite this

Dixon, Jane E. ; Shi, Wenmei ; Wang, Hong Sheng ; McDonald, Christine ; Yu, Hangang ; Wymore, Randy ; Cohen, Ira S. ; McKinnon, David. / Role of the Kv4.3 K+ channel in ventricular muscle : A molecular correlate for the transient outward current. In: Circulation Research. 1996 ; Vol. 79, No. 4. pp. 659-668.
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Role of the Kv4.3 K+ channel in ventricular muscle : A molecular correlate for the transient outward current. / Dixon, Jane E.; Shi, Wenmei; Wang, Hong Sheng; McDonald, Christine; Yu, Hangang; Wymore, Randy; Cohen, Ira S.; McKinnon, David.

In: Circulation Research, Vol. 79, No. 4, 01.01.1996, p. 659-668.

Research output: Contribution to journalArticle

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