Role of calcineurin in stress resistance, morphogenesis, and virulence of a Candida albicans wild-type strain

Teresa Bader, Klaus Schröppel, Stefan Bentink, Nina Agabian, Gerwald Köhler, Joachim Morschhäuser

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

By generating a calcineurin mutant of the Candida albicans wild-type strain SC5314 with the help of a new recyclable dominant selection marker, we confirmed that calcineurin mediates tolerance to a variety of stress conditions but is not required for the ability of C. albicans to switch to filamentous growth in response to hypha-inducing environmental signals. While calcineurin was essential for virulence of C. albicans in a mouse model of disseminated candidiasis, deletion of CMP1 did not significantly affect virulence during vaginal or pulmonary infection, demonstrating that the requirement for calcineurin for a successful infection depends on the host niche.

Original languageEnglish
Pages (from-to)4366-4369
Number of pages4
JournalInfection and Immunity
Volume74
Issue number7
DOIs
StatePublished - Jul 2006

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