Role of calcineurin in stress resistance, morphogenesis, and virulence of a Candida albicans wild-type strain

Teresa Bader, Klaus Schröppel, Stefan Bentink, Nina Agabian, Gerwald Köhler, Joachim Morschhäuser

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

By generating a calcineurin mutant of the Candida albicans wild-type strain SC5314 with the help of a new recyclable dominant selection marker, we confirmed that calcineurin mediates tolerance to a variety of stress conditions but is not required for the ability of C. albicans to switch to filamentous growth in response to hypha-inducing environmental signals. While calcineurin was essential for virulence of C. albicans in a mouse model of disseminated candidiasis, deletion of CMP1 did not significantly affect virulence during vaginal or pulmonary infection, demonstrating that the requirement for calcineurin for a successful infection depends on the host niche.

Original languageEnglish
Pages (from-to)4366-4369
Number of pages4
JournalInfection and Immunity
Volume74
Issue number7
DOIs
StatePublished - 1 Jul 2006

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Calcineurin
Candida albicans
Morphogenesis
Virulence
Hyphae
Candidiasis
Infection
Lung
Growth

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Bader, Teresa ; Schröppel, Klaus ; Bentink, Stefan ; Agabian, Nina ; Köhler, Gerwald ; Morschhäuser, Joachim. / Role of calcineurin in stress resistance, morphogenesis, and virulence of a Candida albicans wild-type strain. In: Infection and Immunity. 2006 ; Vol. 74, No. 7. pp. 4366-4369.
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Role of calcineurin in stress resistance, morphogenesis, and virulence of a Candida albicans wild-type strain. / Bader, Teresa; Schröppel, Klaus; Bentink, Stefan; Agabian, Nina; Köhler, Gerwald; Morschhäuser, Joachim.

In: Infection and Immunity, Vol. 74, No. 7, 01.07.2006, p. 4366-4369.

Research output: Contribution to journalArticle

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