TY - JOUR
T1 - Role of calcineurin in stress resistance, morphogenesis, and virulence of a Candida albicans wild-type strain
AU - Bader, Teresa
AU - Schröppel, Klaus
AU - Bentink, Stefan
AU - Agabian, Nina
AU - Köhler, Gerwald
AU - Morschhäuser, Joachim
PY - 2006/7
Y1 - 2006/7
N2 - By generating a calcineurin mutant of the Candida albicans wild-type strain SC5314 with the help of a new recyclable dominant selection marker, we confirmed that calcineurin mediates tolerance to a variety of stress conditions but is not required for the ability of C. albicans to switch to filamentous growth in response to hypha-inducing environmental signals. While calcineurin was essential for virulence of C. albicans in a mouse model of disseminated candidiasis, deletion of CMP1 did not significantly affect virulence during vaginal or pulmonary infection, demonstrating that the requirement for calcineurin for a successful infection depends on the host niche.
AB - By generating a calcineurin mutant of the Candida albicans wild-type strain SC5314 with the help of a new recyclable dominant selection marker, we confirmed that calcineurin mediates tolerance to a variety of stress conditions but is not required for the ability of C. albicans to switch to filamentous growth in response to hypha-inducing environmental signals. While calcineurin was essential for virulence of C. albicans in a mouse model of disseminated candidiasis, deletion of CMP1 did not significantly affect virulence during vaginal or pulmonary infection, demonstrating that the requirement for calcineurin for a successful infection depends on the host niche.
UR - http://www.scopus.com/inward/record.url?scp=33745625877&partnerID=8YFLogxK
U2 - 10.1128/IAI.00142-06
DO - 10.1128/IAI.00142-06
M3 - Article
C2 - 16790813
AN - SCOPUS:33745625877
SN - 0019-9567
VL - 74
SP - 4366
EP - 4369
JO - Infection and Immunity
JF - Infection and Immunity
IS - 7
ER -