Renal sympathetic nerve activity in sodium retention of acute caval constriction

G. L. Slick, G. F. DiBona, G. J. Kaloyanides

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


The role of renal sympathetic nerve activity in mediating the sodium retention of acute thoracic inferior vena cava constriction was studied in anesthetized dogs with clearance and micropuncture techniques. Combined saline loading and acute caval constriction in control dogs caused an antinatriuresis; there was no change in proximal fractional reabsorption. Maneuvers designed to interrupt renal sympathetic nerve traffic were applied to the left kidney: phenoxybenzamine, surgical renal denervation, and guanethidine. Each intervention resulted in an ipsilateral natriuresis and a fall in proximal fractional reabsorption. The ipsilateral natriuresis could not be explained by alterations in systemic or intrarenal hemodynamics or changes in the intrarenal distribution of blood flow or filtrate. The data provide evidence suggestive of a direct effect of the renal sympathetic nerves on tubular sodium transport.

Original languageEnglish
Pages (from-to)925-932
Number of pages8
JournalAmerican Journal of Physiology
Issue number4
StatePublished - 1974


Dive into the research topics of 'Renal sympathetic nerve activity in sodium retention of acute caval constriction'. Together they form a unique fingerprint.

Cite this