Renal neuroadrenergic transmission

Gary Slick, A. J. Aguilera, E. J. Zambraski, G. F. DiBona, G. J. Kaloyanides

Research output: Contribution to journalArticle

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Abstract

To study the role of the renal sympathetic nerves in the regulation of sodium excretion, we examined the renal functional response to left renal nerve stimulation before (group I) and after (group II) left renal adrenergic blockade with guanethidine. In group I dogs, absolute sodium excretion from the left kidney fell markedly after renal nerve stimulation; the decreases in glomerular filtration rate and renal blood flow were of a similar magnitude. Using the radiolabeled microsphere technique, distribution of renal blood to the outer cortex was diminished after left renal nerve stimulation. In group II dogs, guanethidine blocked all of these effects of left renal nerve stimulation. In group III studies, a low level of left renal nerve stimulation was used which resulted in a decrease in sodium excretion in the absence of changes in glomerular filtration rate, renal blood flow, or intrarenal distribution of blood flow; this effect was blocked by renal adrenergic blockade with guanethidine in group IV studies. These data support a role for the renal sympathetic nerves to directly influence renal tubular sodium transport in the absence of tubular sodium transport in the absence of alterations in renal hemodynamics.

Original languageEnglish
Pages (from-to)60-65
Number of pages6
JournalAmerican Journal of Physiology
Volume229
Issue number1
StatePublished - 1 Dec 1975

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Kidney
Guanethidine
Sodium
Renal Circulation
Glomerular Filtration Rate
Adrenergic Agents
Dogs
Microspheres
Hemodynamics

Cite this

Slick, G., Aguilera, A. J., Zambraski, E. J., DiBona, G. F., & Kaloyanides, G. J. (1975). Renal neuroadrenergic transmission. American Journal of Physiology, 229(1), 60-65.
Slick, Gary ; Aguilera, A. J. ; Zambraski, E. J. ; DiBona, G. F. ; Kaloyanides, G. J. / Renal neuroadrenergic transmission. In: American Journal of Physiology. 1975 ; Vol. 229, No. 1. pp. 60-65.
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Slick, G, Aguilera, AJ, Zambraski, EJ, DiBona, GF & Kaloyanides, GJ 1975, 'Renal neuroadrenergic transmission', American Journal of Physiology, vol. 229, no. 1, pp. 60-65.

Renal neuroadrenergic transmission. / Slick, Gary; Aguilera, A. J.; Zambraski, E. J.; DiBona, G. F.; Kaloyanides, G. J.

In: American Journal of Physiology, Vol. 229, No. 1, 01.12.1975, p. 60-65.

Research output: Contribution to journalArticle

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Slick G, Aguilera AJ, Zambraski EJ, DiBona GF, Kaloyanides GJ. Renal neuroadrenergic transmission. American Journal of Physiology. 1975 Dec 1;229(1):60-65.