Renal nerves and renal responses to volume expansion in conscious monkeys

T. V. Peterson, B. A. Benjamin, N. L. Hurst

Research output: Contribution to journalArticle

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Abstract

Experiments were performed in conscious macaque monkeys to determine the effect of renal denervation on the diuresis and natriuresis of blood volume expansion. When the kidneys were innervated, expansion of estimated blood volume by 20% with 3% dextran in isotonic saline caused increases in urine flow (V̇), from 0.28 ± 0.07 ml/min to a peak response of 1.08 ± 0.20 ml/min, absolute sodium excretion (U(Na)V̇), from 30.0 ± 11.2 to 99.8 ± 11.7 μeq/min, and fractional sodium excretion (FE(Na+)), from 1.24 ± 0.51 to 3.19 ± 0.56%. The animals then underwent bilateral renal denervation and were volume expanded a second time 6-13 days postdenervation. Under this condition, V̇ increased from 0.32 ± 0.05 to 0.64 ± 0.08 ml/min, U(Na)V̇, from 22.2 ± 4.6 to 46.2 ± 8.0 μeq/min, and FE(Na+), from 0.91 ± 0.26 to 1.92 ± 0.41%, these increases being significantly less than when the kidneys were innervated. These results demonstrate that the renal nerves play an important role in the nonhuman primate in mediating increases in renal excretion during hypervolemia.

Original languageEnglish
Pages (from-to)24/3
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume255
Issue number3
StatePublished - 1 Jan 1988

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Haplorhini
Kidney
Denervation
Blood Volume
Sodium
Natriuresis
Diuresis
Macaca
Dextrans
Primates
Urine

Cite this

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abstract = "Experiments were performed in conscious macaque monkeys to determine the effect of renal denervation on the diuresis and natriuresis of blood volume expansion. When the kidneys were innervated, expansion of estimated blood volume by 20{\%} with 3{\%} dextran in isotonic saline caused increases in urine flow (V̇), from 0.28 ± 0.07 ml/min to a peak response of 1.08 ± 0.20 ml/min, absolute sodium excretion (U(Na)V̇), from 30.0 ± 11.2 to 99.8 ± 11.7 μeq/min, and fractional sodium excretion (FE(Na+)), from 1.24 ± 0.51 to 3.19 ± 0.56{\%}. The animals then underwent bilateral renal denervation and were volume expanded a second time 6-13 days postdenervation. Under this condition, V̇ increased from 0.32 ± 0.05 to 0.64 ± 0.08 ml/min, U(Na)V̇, from 22.2 ± 4.6 to 46.2 ± 8.0 μeq/min, and FE(Na+), from 0.91 ± 0.26 to 1.92 ± 0.41{\%}, these increases being significantly less than when the kidneys were innervated. These results demonstrate that the renal nerves play an important role in the nonhuman primate in mediating increases in renal excretion during hypervolemia.",
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Renal nerves and renal responses to volume expansion in conscious monkeys. / Peterson, T. V.; Benjamin, B. A.; Hurst, N. L.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 255, No. 3, 01.01.1988, p. 24/3.

Research output: Contribution to journalArticle

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