Regulation of flagellar length in Chlamydomonas

Nedra Wilson; Janaki Kannan Iyer; Julie A. Buchheim; William Meek

doi:10.1016/j.semcdb.2008.07.005

Regulation of flagellar length in Chlamydomonas

Nedra Wilson, Janaki Kannan Iyer, Julie A. Buchheim, William Meek

Anatomy and Cell Biology

Research output: Contribution to journal › Review article › peer-review

45 Scopus citations

Abstract

Chlamydomonas reinhardtii has two apically localized flagella that are maintained at an equal and appropriate length. Assembly and maintenance of flagella requires a microtubule-based transport system known as intraflagellar transport (IFT). During IFT, proteins destined for incorporation into or removal from a flagellum are carried along doublet microtubules via IFT particles. Regulation of IFT activity therefore is pivotal in determining the length of a flagellum. Reviewed is our current understanding of the role of IFT and signal transduction pathways in the regulation of flagellar length.

Original language	English
Pages (from-to)	494-501
Number of pages	8
Journal	Seminars in Cell and Developmental Biology
Volume	19
Issue number	6
DOIs	https://doi.org/10.1016/j.semcdb.2008.07.005
State	Published - Dec 2008

Keywords

Chlamydomonas
Cilia
Flagellar length
Intraflagellar transport
Signal transduction

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10.1016/j.semcdb.2008.07.005

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title = "Regulation of flagellar length in Chlamydomonas",

abstract = "Chlamydomonas reinhardtii has two apically localized flagella that are maintained at an equal and appropriate length. Assembly and maintenance of flagella requires a microtubule-based transport system known as intraflagellar transport (IFT). During IFT, proteins destined for incorporation into or removal from a flagellum are carried along doublet microtubules via IFT particles. Regulation of IFT activity therefore is pivotal in determining the length of a flagellum. Reviewed is our current understanding of the role of IFT and signal transduction pathways in the regulation of flagellar length.",

keywords = "Chlamydomonas, Cilia, Flagellar length, Intraflagellar transport, Signal transduction",

author = "Nedra Wilson and Iyer, \{Janaki Kannan\} and Buchheim, \{Julie A.\} and William Meek",

year = "2008",

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doi = "10.1016/j.semcdb.2008.07.005",

language = "English",

volume = "19",

pages = "494--501",

journal = "Seminars in Cell and Developmental Biology",

issn = "1084-9521",

publisher = "Elsevier Ltd",

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}

TY - JOUR

T1 - Regulation of flagellar length in Chlamydomonas

AU - Wilson, Nedra

AU - Iyer, Janaki Kannan

AU - Buchheim, Julie A.

AU - Meek, William

PY - 2008/12

Y1 - 2008/12

N2 - Chlamydomonas reinhardtii has two apically localized flagella that are maintained at an equal and appropriate length. Assembly and maintenance of flagella requires a microtubule-based transport system known as intraflagellar transport (IFT). During IFT, proteins destined for incorporation into or removal from a flagellum are carried along doublet microtubules via IFT particles. Regulation of IFT activity therefore is pivotal in determining the length of a flagellum. Reviewed is our current understanding of the role of IFT and signal transduction pathways in the regulation of flagellar length.

AB - Chlamydomonas reinhardtii has two apically localized flagella that are maintained at an equal and appropriate length. Assembly and maintenance of flagella requires a microtubule-based transport system known as intraflagellar transport (IFT). During IFT, proteins destined for incorporation into or removal from a flagellum are carried along doublet microtubules via IFT particles. Regulation of IFT activity therefore is pivotal in determining the length of a flagellum. Reviewed is our current understanding of the role of IFT and signal transduction pathways in the regulation of flagellar length.

KW - Chlamydomonas

KW - Cilia

KW - Flagellar length

KW - Intraflagellar transport

KW - Signal transduction

UR - https://www.scopus.com/pages/publications/54549092001

U2 - 10.1016/j.semcdb.2008.07.005

DO - 10.1016/j.semcdb.2008.07.005

M3 - Review article

C2 - 18692148

AN - SCOPUS:54549092001

SN - 1084-9521

VL - 19

SP - 494

EP - 501

JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

IS - 6

ER -

Regulation of flagellar length in Chlamydomonas

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Keywords

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