Rapid cyclic changes in density and accessibility of endometrial ligands for Escherichia coli Dr fimbriae

Anil K. Kaul, Dhruv Kumar, Manubai Nagamani, Pawel Goluszko, Stella Nowicki, Bogdan J. Nowicki

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

The mechanisms of developing infection in young, noncompromised individuals are not well understood. Colonization is a prerequisite for the development of infection. In humans, ligands serving bacterial colonization belong to common antigens. Consequently, a majority of individuals should be sensitive to infection at all times. We hypothesize that the temporal patterns of some infections and sensitivity to them are associated with sudden changes in the density and accessibility of common receptors. Endometrial samples from women having normal menstrual cycles were examined for histological location, receptor density, and in situ hybridization of Dr (decay-accelerating factor) ligands for Escherichia coli Dr fimbriae. Significant up-regulation and luminal expression of Dr ligands occurred during the secretory phase, whereas receptors were expressed in the basement membrane and in smaller quantities during the proliferative phase. This observation agrees with our hypotheses that some ligands recognized by bacterial adhesins change their compartmentalization and, most importantly, that they up-regulate expression at specific times.

Original languageEnglish
Pages (from-to)611-615
Number of pages5
JournalInfection and Immunity
Volume64
Issue number2
DOIs
StatePublished - 1996

Fingerprint Dive into the research topics of 'Rapid cyclic changes in density and accessibility of endometrial ligands for Escherichia coli Dr fimbriae'. Together they form a unique fingerprint.

  • Cite this