Rapid cyclic changes in density and accessibility of endometrial ligands for Escherichia coli Dr fimbriae

Anil Kaul, Dhruv Kumar, Manubai Nagamani, Pawel Goluszko, Stella Nowicki, Bogdan J. Nowicki

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The mechanisms of developing infection in young, noncompromised individuals are not well understood. Colonization is a prerequisite for the development of infection. In humans, ligands serving bacterial colonization belong to common antigens. Consequently, a majority of individuals should be sensitive to infection at all times. We hypothesize that the temporal patterns of some infections and sensitivity to them are associated with sudden changes in the density and accessibility of common receptors. Endometrial samples from women having normal menstrual cycles were examined for histological location, receptor density, and in situ hybridization of Dr (decay-accelerating factor) ligands for Escherichia coli Dr fimbriae. Significant up-regulation and luminal expression of Dr ligands occurred during the secretory phase, whereas receptors were expressed in the basement membrane and in smaller quantities during the proliferative phase. This observation agrees with our hypotheses that some ligands recognized by bacterial adhesins change their compartmentalization and, most importantly, that they up-regulate expression at specific times.

Original languageEnglish
Pages (from-to)611-615
Number of pages5
JournalInfection and Immunity
Volume64
Issue number2
StatePublished - 29 Jan 1996

Fingerprint

Escherichia coli
Ligands
Infection
Up-Regulation
Bacterial Adhesins
CD55 Antigens
Menstrual Cycle
Basement Membrane
In Situ Hybridization
Antigens

Cite this

Kaul, A., Kumar, D., Nagamani, M., Goluszko, P., Nowicki, S., & Nowicki, B. J. (1996). Rapid cyclic changes in density and accessibility of endometrial ligands for Escherichia coli Dr fimbriae. Infection and Immunity, 64(2), 611-615.
Kaul, Anil ; Kumar, Dhruv ; Nagamani, Manubai ; Goluszko, Pawel ; Nowicki, Stella ; Nowicki, Bogdan J. / Rapid cyclic changes in density and accessibility of endometrial ligands for Escherichia coli Dr fimbriae. In: Infection and Immunity. 1996 ; Vol. 64, No. 2. pp. 611-615.
@article{49dfd8bf40e442d0bae07bdfa15edede,
title = "Rapid cyclic changes in density and accessibility of endometrial ligands for Escherichia coli Dr fimbriae",
abstract = "The mechanisms of developing infection in young, noncompromised individuals are not well understood. Colonization is a prerequisite for the development of infection. In humans, ligands serving bacterial colonization belong to common antigens. Consequently, a majority of individuals should be sensitive to infection at all times. We hypothesize that the temporal patterns of some infections and sensitivity to them are associated with sudden changes in the density and accessibility of common receptors. Endometrial samples from women having normal menstrual cycles were examined for histological location, receptor density, and in situ hybridization of Dr (decay-accelerating factor) ligands for Escherichia coli Dr fimbriae. Significant up-regulation and luminal expression of Dr ligands occurred during the secretory phase, whereas receptors were expressed in the basement membrane and in smaller quantities during the proliferative phase. This observation agrees with our hypotheses that some ligands recognized by bacterial adhesins change their compartmentalization and, most importantly, that they up-regulate expression at specific times.",
author = "Anil Kaul and Dhruv Kumar and Manubai Nagamani and Pawel Goluszko and Stella Nowicki and Nowicki, {Bogdan J.}",
year = "1996",
month = "1",
day = "29",
language = "English",
volume = "64",
pages = "611--615",
journal = "Infection and Immunity",
issn = "0019-9567",
publisher = "American Society for Microbiology",
number = "2",

}

Kaul, A, Kumar, D, Nagamani, M, Goluszko, P, Nowicki, S & Nowicki, BJ 1996, 'Rapid cyclic changes in density and accessibility of endometrial ligands for Escherichia coli Dr fimbriae', Infection and Immunity, vol. 64, no. 2, pp. 611-615.

Rapid cyclic changes in density and accessibility of endometrial ligands for Escherichia coli Dr fimbriae. / Kaul, Anil; Kumar, Dhruv; Nagamani, Manubai; Goluszko, Pawel; Nowicki, Stella; Nowicki, Bogdan J.

In: Infection and Immunity, Vol. 64, No. 2, 29.01.1996, p. 611-615.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Rapid cyclic changes in density and accessibility of endometrial ligands for Escherichia coli Dr fimbriae

AU - Kaul, Anil

AU - Kumar, Dhruv

AU - Nagamani, Manubai

AU - Goluszko, Pawel

AU - Nowicki, Stella

AU - Nowicki, Bogdan J.

PY - 1996/1/29

Y1 - 1996/1/29

N2 - The mechanisms of developing infection in young, noncompromised individuals are not well understood. Colonization is a prerequisite for the development of infection. In humans, ligands serving bacterial colonization belong to common antigens. Consequently, a majority of individuals should be sensitive to infection at all times. We hypothesize that the temporal patterns of some infections and sensitivity to them are associated with sudden changes in the density and accessibility of common receptors. Endometrial samples from women having normal menstrual cycles were examined for histological location, receptor density, and in situ hybridization of Dr (decay-accelerating factor) ligands for Escherichia coli Dr fimbriae. Significant up-regulation and luminal expression of Dr ligands occurred during the secretory phase, whereas receptors were expressed in the basement membrane and in smaller quantities during the proliferative phase. This observation agrees with our hypotheses that some ligands recognized by bacterial adhesins change their compartmentalization and, most importantly, that they up-regulate expression at specific times.

AB - The mechanisms of developing infection in young, noncompromised individuals are not well understood. Colonization is a prerequisite for the development of infection. In humans, ligands serving bacterial colonization belong to common antigens. Consequently, a majority of individuals should be sensitive to infection at all times. We hypothesize that the temporal patterns of some infections and sensitivity to them are associated with sudden changes in the density and accessibility of common receptors. Endometrial samples from women having normal menstrual cycles were examined for histological location, receptor density, and in situ hybridization of Dr (decay-accelerating factor) ligands for Escherichia coli Dr fimbriae. Significant up-regulation and luminal expression of Dr ligands occurred during the secretory phase, whereas receptors were expressed in the basement membrane and in smaller quantities during the proliferative phase. This observation agrees with our hypotheses that some ligands recognized by bacterial adhesins change their compartmentalization and, most importantly, that they up-regulate expression at specific times.

UR - http://www.scopus.com/inward/record.url?scp=0030052765&partnerID=8YFLogxK

M3 - Article

C2 - 8550215

AN - SCOPUS:0030052765

VL - 64

SP - 611

EP - 615

JO - Infection and Immunity

JF - Infection and Immunity

SN - 0019-9567

IS - 2

ER -