Prostate Adenocarcinoma With Atypical Immunohistochemistry Presenting With a Cheerio Sign

Creticus Marak, Achuta Kumar Guddati, Adrita Ashraf, James Smith, Prashant Kaushik

Research output: Contribution to journalArticlepeer-review


The most common cancer in men is prostate cancer. The Cheerio sign is the computed tomography finding of multiple pulmonary nodules with central lucency resembling the ring-shaped Cheerio breakfast cereal. Unlike bone metastasis, pulmonary involvement is less common. The Cheerio sign has malignant and benign etiologies. Thyroid transcription factor-1 (TTF-1) stain is commonly used in the diagnosis of primary lung cancer. TTF-1 positivity in cancers of prostate origin is rare, with only case reports and small case series available in the literature. Metastatic prostate cancer presenting with a Cheerio sign has not been reported in the literature.

Original languageEnglish
Article numbere220508
JournalAnnals of Internal Medicine Clinical Cases
Issue number9
StatePublished - Nov 2022
Externally publishedYes


  • Adenocarcinoma
  • Bone
  • Immunohistochemistry
  • Lung and intrathoracic tumors
  • Lungs
  • Metastasis
  • Metastatic tumors
  • Prostate cancer
  • Small cell lung cancer
  • Thorax


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