Propranolol blocks metabolic rate increase but not ventilatory acclimatization to 4300 m

Lorna Grindlay Moore, Allen Cymerman, Shao Yung Huang, Robert E. McCullough, Rosann G. McCullough, Paul Rock, Andrew Young, Patricia Young, John V. Weil, John T. Reeves

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Previously, we found resting metabolic rate increased at high altitude but the mechanism and consequences of this increase were unclear. We sought to test the role of beta-sympathetic activation for increasing metabolic rate and the contribution of an increase in metabolic rate to raising total ventilation at altitude. Following baseline studies at sea level, two groups of six healthy male subjects received either placebo or propranolol (80 mg/8 h) for 3 days prior to ascent to Pikes Peak (4300 m) where treatment was continued for 15 days. O2 consumption increased in placebo-treated subjects with a rise of 20 ± 5%(X ± SEM) on day 1 and no change 0 ± 7% in propranolol-treated subjects (difference between groups, P < 0.05). The increase in total ventilation upon ascent was 28 ± 2% in the placebo group vs 9 ± 7% in the propranolol group (P < 0.05) and was correlated with metabolic rate in individual subjects. Decreasing end-tidal PCO2, taken as an index of ventilatory acclimization, was similar in both groups. Thus, beta-sympathetic activation appears to increase metabolic rate upon ascent to high altitude and lead to a proportionate elevation in total ventilation but does not alter ventilatory acclimization.

Original languageEnglish
Pages (from-to)195-204
Number of pages10
JournalRespiration Physiology
Volume70
Issue number2
DOIs
StatePublished - 1 Jan 1987

Fingerprint

Acclimatization
Propranolol
Ventilation
Placebos
Esocidae
Basal Metabolism
Oceans and Seas
Healthy Volunteers
Therapeutics

Keywords

  • Beta-adrenergic
  • High altitude
  • O consumption
  • Sympathetic nervous system
  • Ventilation
  • Ventilatory acclimization

Cite this

Moore, L. G., Cymerman, A., Huang, S. Y., McCullough, R. E., McCullough, R. G., Rock, P., ... Reeves, J. T. (1987). Propranolol blocks metabolic rate increase but not ventilatory acclimatization to 4300 m. Respiration Physiology, 70(2), 195-204. https://doi.org/10.1016/0034-5687(87)90050-8
Moore, Lorna Grindlay ; Cymerman, Allen ; Huang, Shao Yung ; McCullough, Robert E. ; McCullough, Rosann G. ; Rock, Paul ; Young, Andrew ; Young, Patricia ; Weil, John V. ; Reeves, John T. / Propranolol blocks metabolic rate increase but not ventilatory acclimatization to 4300 m. In: Respiration Physiology. 1987 ; Vol. 70, No. 2. pp. 195-204.
@article{92f69c20a5c84870b94a8fa616758cf5,
title = "Propranolol blocks metabolic rate increase but not ventilatory acclimatization to 4300 m",
abstract = "Previously, we found resting metabolic rate increased at high altitude but the mechanism and consequences of this increase were unclear. We sought to test the role of beta-sympathetic activation for increasing metabolic rate and the contribution of an increase in metabolic rate to raising total ventilation at altitude. Following baseline studies at sea level, two groups of six healthy male subjects received either placebo or propranolol (80 mg/8 h) for 3 days prior to ascent to Pikes Peak (4300 m) where treatment was continued for 15 days. O2 consumption increased in placebo-treated subjects with a rise of 20 ± 5{\%}(X ± SEM) on day 1 and no change 0 ± 7{\%} in propranolol-treated subjects (difference between groups, P < 0.05). The increase in total ventilation upon ascent was 28 ± 2{\%} in the placebo group vs 9 ± 7{\%} in the propranolol group (P < 0.05) and was correlated with metabolic rate in individual subjects. Decreasing end-tidal PCO2, taken as an index of ventilatory acclimization, was similar in both groups. Thus, beta-sympathetic activation appears to increase metabolic rate upon ascent to high altitude and lead to a proportionate elevation in total ventilation but does not alter ventilatory acclimization.",
keywords = "Beta-adrenergic, High altitude, O consumption, Sympathetic nervous system, Ventilation, Ventilatory acclimization",
author = "Moore, {Lorna Grindlay} and Allen Cymerman and Huang, {Shao Yung} and McCullough, {Robert E.} and McCullough, {Rosann G.} and Paul Rock and Andrew Young and Patricia Young and Weil, {John V.} and Reeves, {John T.}",
year = "1987",
month = "1",
day = "1",
doi = "10.1016/0034-5687(87)90050-8",
language = "English",
volume = "70",
pages = "195--204",
journal = "Respiration Physiology",
issn = "0034-5687",
publisher = "Elsevier BV",
number = "2",

}

Moore, LG, Cymerman, A, Huang, SY, McCullough, RE, McCullough, RG, Rock, P, Young, A, Young, P, Weil, JV & Reeves, JT 1987, 'Propranolol blocks metabolic rate increase but not ventilatory acclimatization to 4300 m', Respiration Physiology, vol. 70, no. 2, pp. 195-204. https://doi.org/10.1016/0034-5687(87)90050-8

Propranolol blocks metabolic rate increase but not ventilatory acclimatization to 4300 m. / Moore, Lorna Grindlay; Cymerman, Allen; Huang, Shao Yung; McCullough, Robert E.; McCullough, Rosann G.; Rock, Paul; Young, Andrew; Young, Patricia; Weil, John V.; Reeves, John T.

In: Respiration Physiology, Vol. 70, No. 2, 01.01.1987, p. 195-204.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Propranolol blocks metabolic rate increase but not ventilatory acclimatization to 4300 m

AU - Moore, Lorna Grindlay

AU - Cymerman, Allen

AU - Huang, Shao Yung

AU - McCullough, Robert E.

AU - McCullough, Rosann G.

AU - Rock, Paul

AU - Young, Andrew

AU - Young, Patricia

AU - Weil, John V.

AU - Reeves, John T.

PY - 1987/1/1

Y1 - 1987/1/1

N2 - Previously, we found resting metabolic rate increased at high altitude but the mechanism and consequences of this increase were unclear. We sought to test the role of beta-sympathetic activation for increasing metabolic rate and the contribution of an increase in metabolic rate to raising total ventilation at altitude. Following baseline studies at sea level, two groups of six healthy male subjects received either placebo or propranolol (80 mg/8 h) for 3 days prior to ascent to Pikes Peak (4300 m) where treatment was continued for 15 days. O2 consumption increased in placebo-treated subjects with a rise of 20 ± 5%(X ± SEM) on day 1 and no change 0 ± 7% in propranolol-treated subjects (difference between groups, P < 0.05). The increase in total ventilation upon ascent was 28 ± 2% in the placebo group vs 9 ± 7% in the propranolol group (P < 0.05) and was correlated with metabolic rate in individual subjects. Decreasing end-tidal PCO2, taken as an index of ventilatory acclimization, was similar in both groups. Thus, beta-sympathetic activation appears to increase metabolic rate upon ascent to high altitude and lead to a proportionate elevation in total ventilation but does not alter ventilatory acclimization.

AB - Previously, we found resting metabolic rate increased at high altitude but the mechanism and consequences of this increase were unclear. We sought to test the role of beta-sympathetic activation for increasing metabolic rate and the contribution of an increase in metabolic rate to raising total ventilation at altitude. Following baseline studies at sea level, two groups of six healthy male subjects received either placebo or propranolol (80 mg/8 h) for 3 days prior to ascent to Pikes Peak (4300 m) where treatment was continued for 15 days. O2 consumption increased in placebo-treated subjects with a rise of 20 ± 5%(X ± SEM) on day 1 and no change 0 ± 7% in propranolol-treated subjects (difference between groups, P < 0.05). The increase in total ventilation upon ascent was 28 ± 2% in the placebo group vs 9 ± 7% in the propranolol group (P < 0.05) and was correlated with metabolic rate in individual subjects. Decreasing end-tidal PCO2, taken as an index of ventilatory acclimization, was similar in both groups. Thus, beta-sympathetic activation appears to increase metabolic rate upon ascent to high altitude and lead to a proportionate elevation in total ventilation but does not alter ventilatory acclimization.

KW - Beta-adrenergic

KW - High altitude

KW - O consumption

KW - Sympathetic nervous system

KW - Ventilation

KW - Ventilatory acclimization

UR - http://www.scopus.com/inward/record.url?scp=0023526040&partnerID=8YFLogxK

U2 - 10.1016/0034-5687(87)90050-8

DO - 10.1016/0034-5687(87)90050-8

M3 - Article

C2 - 3671899

AN - SCOPUS:0023526040

VL - 70

SP - 195

EP - 204

JO - Respiration Physiology

JF - Respiration Physiology

SN - 0034-5687

IS - 2

ER -