Prenatal cocaine exposure alters alpha2 receptor expression in adolescent rats

Rosemarie M. Booze, David R. Wallace, Janelle M. Silvers, Barbara J. Strupp, Diane M. Snow, Charles F. Mactutus

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Background: Prenatal cocaine exposure produces attentional deficits which to persist through early childhood. Given the role of norepinephrine (NE) in attentional processes, we examined the forebrain NE systems from prenatal cocaine exposed rats. Cocaine was administered during pregnancy via the clinically relevant intravenous route of administration. Specifically, we measured α2-adrenergic receptor (α2-AR) density in adolescent (35-days-old) rats, using [3H]RX821002 (5 nM). Results: Sex-specific alterations of α2-AR were found in the hippocampus and amygdala of the cocaine-exposed animals, as well as an upregulation of α2-AR in parietal cortex. Conclusion: These data suggest that prenatal cocaine exposure results in a persistent alteration in forebrain NE systems as indicated by alterations in receptor density. These neurochemical changes may underlie behavioral abnormalities observed in offspring attentional processes following prenatal exposure to cocaine.

Original languageEnglish
Article number33
JournalBMC Neuroscience
Volume7
DOIs
StatePublished - 18 Apr 2006

Fingerprint Dive into the research topics of 'Prenatal cocaine exposure alters alpha2 receptor expression in adolescent rats'. Together they form a unique fingerprint.

  • Cite this