Prenatal cocaine exposure alters alpha2 receptor expression in adolescent rats

Rosemarie M. Booze, David Wallace, Janelle M. Silvers, Barbara J. Strupp, Diane M. Snow, Charles F. Mactutus

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Prenatal cocaine exposure produces attentional deficits which to persist through early childhood. Given the role of norepinephrine (NE) in attentional processes, we examined the forebrain NE systems from prenatal cocaine exposed rats. Cocaine was administered during pregnancy via the clinically relevant intravenous route of administration. Specifically, we measured α2-adrenergic receptor (α2-AR) density in adolescent (35-days-old) rats, using [3H]RX821002 (5 nM). Results: Sex-specific alterations of α2-AR were found in the hippocampus and amygdala of the cocaine-exposed animals, as well as an upregulation of α2-AR in parietal cortex. Conclusion: These data suggest that prenatal cocaine exposure results in a persistent alteration in forebrain NE systems as indicated by alterations in receptor density. These neurochemical changes may underlie behavioral abnormalities observed in offspring attentional processes following prenatal exposure to cocaine.

Original languageEnglish
Article number33
JournalBMC Neuroscience
Volume7
DOIs
StatePublished - 18 Apr 2006

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Cocaine
Adrenergic Receptors
Norepinephrine
Prosencephalon
Parietal Lobe
Amygdala
Intravenous Administration
Hippocampus
Up-Regulation
Pregnancy

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Booze, R. M., Wallace, D., Silvers, J. M., Strupp, B. J., Snow, D. M., & Mactutus, C. F. (2006). Prenatal cocaine exposure alters alpha2 receptor expression in adolescent rats. BMC Neuroscience, 7, [33]. https://doi.org/10.1186/1471-2202-7-33
Booze, Rosemarie M. ; Wallace, David ; Silvers, Janelle M. ; Strupp, Barbara J. ; Snow, Diane M. ; Mactutus, Charles F. / Prenatal cocaine exposure alters alpha2 receptor expression in adolescent rats. In: BMC Neuroscience. 2006 ; Vol. 7.
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Prenatal cocaine exposure alters alpha2 receptor expression in adolescent rats. / Booze, Rosemarie M.; Wallace, David; Silvers, Janelle M.; Strupp, Barbara J.; Snow, Diane M.; Mactutus, Charles F.

In: BMC Neuroscience, Vol. 7, 33, 18.04.2006.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prenatal cocaine exposure alters alpha2 receptor expression in adolescent rats

AU - Booze, Rosemarie M.

AU - Wallace, David

AU - Silvers, Janelle M.

AU - Strupp, Barbara J.

AU - Snow, Diane M.

AU - Mactutus, Charles F.

PY - 2006/4/18

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