TY - JOUR
T1 - Phospholipase A2 and Phospholipase B activities in fungi
AU - Köhler, Gerwald A.
AU - Brenot, Audrey
AU - Haas-Stapleton, Eric
AU - Agabian, Nina
AU - Deva, Rupal
AU - Nigam, Santosh
N1 - Funding Information:
The authors would like to thank the Volkswagen Foundation, Germany (1/74643) for financial support. This work was also supported by NIH/NIDCR grants P01 DE16839 (N. Agabian) and R21 DE014705 (G. A. Köhler) as well as UCSF/ARI-CARC grant CC02-SF-002 (N. Agabian).
PY - 2006/11
Y1 - 2006/11
N2 - As saprophytes or disease causing microorganisms, fungi acquire nutrients from dead organic material or living host organisms. Lipids as structural components of cell membranes and storage compartments play an important role as energy-rich food source. In recent years, it also has become clear that lipids have a wide range of bioactive properties including signal transduction and cell to cell communication. Thus, it is not surprising that fungi possess a broad range of hydrolytic enzymes that attack neutral lipids and phospholipids. Especially during infection of a mammalian host, phospholipase A2 (PLA2) enzymes released by fungi could play important roles not only for nutrient acquisition and tissue invasion, but for intricate modulation of the host's immune response. Sequencing of fungal genomes has revealed a wide range of genes encoding PLA2 activities in fungi. We are just beginning to become aware of the significance these enzymes could have for the fungal cells and their interaction with the host.
AB - As saprophytes or disease causing microorganisms, fungi acquire nutrients from dead organic material or living host organisms. Lipids as structural components of cell membranes and storage compartments play an important role as energy-rich food source. In recent years, it also has become clear that lipids have a wide range of bioactive properties including signal transduction and cell to cell communication. Thus, it is not surprising that fungi possess a broad range of hydrolytic enzymes that attack neutral lipids and phospholipids. Especially during infection of a mammalian host, phospholipase A2 (PLA2) enzymes released by fungi could play important roles not only for nutrient acquisition and tissue invasion, but for intricate modulation of the host's immune response. Sequencing of fungal genomes has revealed a wide range of genes encoding PLA2 activities in fungi. We are just beginning to become aware of the significance these enzymes could have for the fungal cells and their interaction with the host.
KW - Aspergillus fumigatus
KW - Candida albicans
KW - Cryptcoccus neoformans
KW - PLB gene
KW - Phospholipase A2
UR - http://www.scopus.com/inward/record.url?scp=33750965424&partnerID=8YFLogxK
U2 - 10.1016/j.bbalip.2006.09.011
DO - 10.1016/j.bbalip.2006.09.011
M3 - Review article
C2 - 17081801
AN - SCOPUS:33750965424
SN - 1388-1981
VL - 1761
SP - 1391
EP - 1399
JO - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
JF - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
IS - 11
ER -