Pathophysiology of SARS-CoV-2 Infection and COVID-19

Teluguakula Narasaraju, Marko Radic, Anil Kaul

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


A detailed understanding of the pathophysiologic mechanisms of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) infection and Coronavirus disease 2019 (COVID-19) is vital for improving patient management - to facilitate prompt recognition of progression to severe disease and effective therapeutic strategies. This chapter summarizes the underlyingpathophysiology in the lungs and other organs of COVID- 19 patients. The roles of the cytokine storm culminating in exaggerated inflammatory responses and formation of neutrophil extracellular traps (NETs) are discussed. Pathological features of the various stages from the onset of COVID-19 are outlined - progressing from early mild infection to severe clinical illness to the critically ill phase.

Original languageEnglish
Title of host publicationUncovering The Science of Covid-19
PublisherWorld Scientific Publishing Co.
Number of pages10
ISBN (Electronic)9789811254338
ISBN (Print)9789811254321
StatePublished - 1 Jan 2022


  • COVID-19 pathology in liver
  • COVID-19 pathophysiology
  • acute respiratory distress syndrome
  • blood vessels
  • chemokines
  • critically ill phase
  • cytokine storm
  • cytokines
  • early mild SARS-CoV-2 infection
  • gross pathology
  • heart
  • histopathology
  • hyperinflammatory responses
  • immune cells
  • lungs
  • neutrophil extracellular traps
  • neutrophilia
  • severe clinical illness


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