Pathophysiology of SARS-CoV-2 Infection and COVID-19

Teluguakula Narasaraju; Marko Radic; Anil Kaul

doi:10.1142/9789811254338_0008

Pathophysiology of SARS-CoV-2 Infection and COVID-19

Teluguakula Narasaraju, Marko Radic, Anil Kaul

School of Health Care Administration

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

A detailed understanding of the pathophysiologic mechanisms of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) infection and Coronavirus disease 2019 (COVID-19) is vital for improving patient management - to facilitate prompt recognition of progression to severe disease and effective therapeutic strategies. This chapter summarizes the underlyingpathophysiology in the lungs and other organs of COVID- 19 patients. The roles of the cytokine storm culminating in exaggerated inflammatory responses and formation of neutrophil extracellular traps (NETs) are discussed. Pathological features of the various stages from the onset of COVID-19 are outlined - progressing from early mild infection to severe clinical illness to the critically ill phase.

Original language	English
Title of host publication	Uncovering The Science of Covid-19
Publisher	World Scientific Publishing Co.
Pages	223-232
Number of pages	10
ISBN (Electronic)	9789811254338
ISBN (Print)	9789811254321
DOIs	https://doi.org/10.1142/9789811254338_0008
State	Published - 1 Jan 2022

Keywords

COVID-19 pathology in liver
COVID-19 pathophysiology
acute respiratory distress syndrome
blood vessels
chemokines
critically ill phase
cytokine storm
cytokines
early mild SARS-CoV-2 infection
gross pathology
heart
histopathology
hyperinflammatory responses
immune cells
lungs
neutrophil extracellular traps
neutrophilia
severe clinical illness

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10.1142/9789811254338_0008

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abstract = "A detailed understanding of the pathophysiologic mechanisms of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) infection and Coronavirus disease 2019 (COVID-19) is vital for improving patient management - to facilitate prompt recognition of progression to severe disease and effective therapeutic strategies. This chapter summarizes the underlyingpathophysiology in the lungs and other organs of COVID- 19 patients. The roles of the cytokine storm culminating in exaggerated inflammatory responses and formation of neutrophil extracellular traps (NETs) are discussed. Pathological features of the various stages from the onset of COVID-19 are outlined - progressing from early mild infection to severe clinical illness to the critically ill phase.",

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Pathophysiology of SARS-CoV-2 Infection and COVID-19

Abstract

Keywords

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