Abstract
Humans are exposed to a significant number of chemicals that are suspected to produce disturbances in hormone homeostasis. Hence, in recent decades, there has been a growing interest in endocrine disruptive chemicals. One of the alleged thyroid disrupting substances is cadmium (Cd), a ubiquitous toxic metal shown to act as a thyroid disruptor and carcinogen in both animals and humans. Multiple PubMed searches with core keywords were performed to identify and evaluate appropriate studies which revealed literature suggesting evidence for the link between exposure to Cd and histological and metabolic changes in the thyroid gland. Furthermore, Cd influence on thyroid homeostasis at the peripheral level has also been hypothesized. Both in vivo and in vitro studies revealed that a Cd exposure at environmentally relevant concentrations results in biphasic Cd dose-thyroid response relationships. Development of thyroid tumors following exposure to Cd has been studied mainly using in vitro methodologies. In the thyroid, Cd has been shown to activate or stimulate the activity of various factors, leading to increased cell proliferation and a reduction in normal apoptotic activity. Evidence establishing the association between Cd and thyroid disruption remains ambiguous, with further studies needed to elucidate the issue and improve our understanding of Cd-mediated effects on the thyroid gland.
| Original language | English |
|---|---|
| Article number | 1501 |
| Journal | International Journal of Molecular Sciences |
| Volume | 19 |
| Issue number | 5 |
| DOIs | |
| State | Published - 17 May 2018 |
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Keywords
- Cadmium
- Endocrine disruption
- Mechanisms
- Thyroid gland
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}
Overview of cadmium thyroid disrupting effects and mechanisms. / Buha, Aleksandra; Matovic, Vesna; Antonijevic, Biljana; Bulat, Zorica; Curcic, Marijana; Renieri, Elisavet A.; Tsatsakis, Aristidis M.; Schweitzer, Amie; Wallace, David.
In: International Journal of Molecular Sciences, Vol. 19, No. 5, 1501, 17.05.2018.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Overview of cadmium thyroid disrupting effects and mechanisms
AU - Buha, Aleksandra
AU - Matovic, Vesna
AU - Antonijevic, Biljana
AU - Bulat, Zorica
AU - Curcic, Marijana
AU - Renieri, Elisavet A.
AU - Tsatsakis, Aristidis M.
AU - Schweitzer, Amie
AU - Wallace, David
PY - 2018/5/17
Y1 - 2018/5/17
N2 - Humans are exposed to a significant number of chemicals that are suspected to produce disturbances in hormone homeostasis. Hence, in recent decades, there has been a growing interest in endocrine disruptive chemicals. One of the alleged thyroid disrupting substances is cadmium (Cd), a ubiquitous toxic metal shown to act as a thyroid disruptor and carcinogen in both animals and humans. Multiple PubMed searches with core keywords were performed to identify and evaluate appropriate studies which revealed literature suggesting evidence for the link between exposure to Cd and histological and metabolic changes in the thyroid gland. Furthermore, Cd influence on thyroid homeostasis at the peripheral level has also been hypothesized. Both in vivo and in vitro studies revealed that a Cd exposure at environmentally relevant concentrations results in biphasic Cd dose-thyroid response relationships. Development of thyroid tumors following exposure to Cd has been studied mainly using in vitro methodologies. In the thyroid, Cd has been shown to activate or stimulate the activity of various factors, leading to increased cell proliferation and a reduction in normal apoptotic activity. Evidence establishing the association between Cd and thyroid disruption remains ambiguous, with further studies needed to elucidate the issue and improve our understanding of Cd-mediated effects on the thyroid gland.
AB - Humans are exposed to a significant number of chemicals that are suspected to produce disturbances in hormone homeostasis. Hence, in recent decades, there has been a growing interest in endocrine disruptive chemicals. One of the alleged thyroid disrupting substances is cadmium (Cd), a ubiquitous toxic metal shown to act as a thyroid disruptor and carcinogen in both animals and humans. Multiple PubMed searches with core keywords were performed to identify and evaluate appropriate studies which revealed literature suggesting evidence for the link between exposure to Cd and histological and metabolic changes in the thyroid gland. Furthermore, Cd influence on thyroid homeostasis at the peripheral level has also been hypothesized. Both in vivo and in vitro studies revealed that a Cd exposure at environmentally relevant concentrations results in biphasic Cd dose-thyroid response relationships. Development of thyroid tumors following exposure to Cd has been studied mainly using in vitro methodologies. In the thyroid, Cd has been shown to activate or stimulate the activity of various factors, leading to increased cell proliferation and a reduction in normal apoptotic activity. Evidence establishing the association between Cd and thyroid disruption remains ambiguous, with further studies needed to elucidate the issue and improve our understanding of Cd-mediated effects on the thyroid gland.
KW - Cadmium
KW - Endocrine disruption
KW - Mechanisms
KW - Thyroid gland
UR - http://www.scopus.com/inward/record.url?scp=85047250921&partnerID=8YFLogxK
U2 - 10.3390/ijms19051501
DO - 10.3390/ijms19051501
M3 - Review article
C2 - 29772829
AN - SCOPUS:85047250921
VL - 19
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1661-6596
IS - 5
M1 - 1501
ER -