Overview of cadmium thyroid disrupting effects and mechanisms

Aleksandra Buha, Vesna Matovic, Biljana Antonijevic, Zorica Bulat, Marijana Curcic, Elisavet A. Renieri, Aristidis M. Tsatsakis, Amie Schweitzer, David Wallace

Research output: Contribution to journalReview article

24 Citations (Scopus)

Abstract

Humans are exposed to a significant number of chemicals that are suspected to produce disturbances in hormone homeostasis. Hence, in recent decades, there has been a growing interest in endocrine disruptive chemicals. One of the alleged thyroid disrupting substances is cadmium (Cd), a ubiquitous toxic metal shown to act as a thyroid disruptor and carcinogen in both animals and humans. Multiple PubMed searches with core keywords were performed to identify and evaluate appropriate studies which revealed literature suggesting evidence for the link between exposure to Cd and histological and metabolic changes in the thyroid gland. Furthermore, Cd influence on thyroid homeostasis at the peripheral level has also been hypothesized. Both in vivo and in vitro studies revealed that a Cd exposure at environmentally relevant concentrations results in biphasic Cd dose-thyroid response relationships. Development of thyroid tumors following exposure to Cd has been studied mainly using in vitro methodologies. In the thyroid, Cd has been shown to activate or stimulate the activity of various factors, leading to increased cell proliferation and a reduction in normal apoptotic activity. Evidence establishing the association between Cd and thyroid disruption remains ambiguous, with further studies needed to elucidate the issue and improve our understanding of Cd-mediated effects on the thyroid gland.

Original languageEnglish
Article number1501
JournalInternational Journal of Molecular Sciences
Volume19
Issue number5
DOIs
StatePublished - 17 May 2018

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disrupting
Cadmium
cadmium
Thyroid Gland
thyroid gland
homeostasis
Homeostasis
carcinogens
Carcinogens
hormones
Poisons
Hormones
Cell proliferation
PubMed
animals
Tumors
Animals
disturbances
tumors
Thermodynamic properties

Keywords

  • Cadmium
  • Endocrine disruption
  • Mechanisms
  • Thyroid gland

Cite this

Buha, A., Matovic, V., Antonijevic, B., Bulat, Z., Curcic, M., Renieri, E. A., ... Wallace, D. (2018). Overview of cadmium thyroid disrupting effects and mechanisms. International Journal of Molecular Sciences, 19(5), [1501]. https://doi.org/10.3390/ijms19051501
Buha, Aleksandra ; Matovic, Vesna ; Antonijevic, Biljana ; Bulat, Zorica ; Curcic, Marijana ; Renieri, Elisavet A. ; Tsatsakis, Aristidis M. ; Schweitzer, Amie ; Wallace, David. / Overview of cadmium thyroid disrupting effects and mechanisms. In: International Journal of Molecular Sciences. 2018 ; Vol. 19, No. 5.
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Buha, A, Matovic, V, Antonijevic, B, Bulat, Z, Curcic, M, Renieri, EA, Tsatsakis, AM, Schweitzer, A & Wallace, D 2018, 'Overview of cadmium thyroid disrupting effects and mechanisms', International Journal of Molecular Sciences, vol. 19, no. 5, 1501. https://doi.org/10.3390/ijms19051501

Overview of cadmium thyroid disrupting effects and mechanisms. / Buha, Aleksandra; Matovic, Vesna; Antonijevic, Biljana; Bulat, Zorica; Curcic, Marijana; Renieri, Elisavet A.; Tsatsakis, Aristidis M.; Schweitzer, Amie; Wallace, David.

In: International Journal of Molecular Sciences, Vol. 19, No. 5, 1501, 17.05.2018.

Research output: Contribution to journalReview article

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AU - Buha, Aleksandra

AU - Matovic, Vesna

AU - Antonijevic, Biljana

AU - Bulat, Zorica

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AU - Renieri, Elisavet A.

AU - Tsatsakis, Aristidis M.

AU - Schweitzer, Amie

AU - Wallace, David

PY - 2018/5/17

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N2 - Humans are exposed to a significant number of chemicals that are suspected to produce disturbances in hormone homeostasis. Hence, in recent decades, there has been a growing interest in endocrine disruptive chemicals. One of the alleged thyroid disrupting substances is cadmium (Cd), a ubiquitous toxic metal shown to act as a thyroid disruptor and carcinogen in both animals and humans. Multiple PubMed searches with core keywords were performed to identify and evaluate appropriate studies which revealed literature suggesting evidence for the link between exposure to Cd and histological and metabolic changes in the thyroid gland. Furthermore, Cd influence on thyroid homeostasis at the peripheral level has also been hypothesized. Both in vivo and in vitro studies revealed that a Cd exposure at environmentally relevant concentrations results in biphasic Cd dose-thyroid response relationships. Development of thyroid tumors following exposure to Cd has been studied mainly using in vitro methodologies. In the thyroid, Cd has been shown to activate or stimulate the activity of various factors, leading to increased cell proliferation and a reduction in normal apoptotic activity. Evidence establishing the association between Cd and thyroid disruption remains ambiguous, with further studies needed to elucidate the issue and improve our understanding of Cd-mediated effects on the thyroid gland.

AB - Humans are exposed to a significant number of chemicals that are suspected to produce disturbances in hormone homeostasis. Hence, in recent decades, there has been a growing interest in endocrine disruptive chemicals. One of the alleged thyroid disrupting substances is cadmium (Cd), a ubiquitous toxic metal shown to act as a thyroid disruptor and carcinogen in both animals and humans. Multiple PubMed searches with core keywords were performed to identify and evaluate appropriate studies which revealed literature suggesting evidence for the link between exposure to Cd and histological and metabolic changes in the thyroid gland. Furthermore, Cd influence on thyroid homeostasis at the peripheral level has also been hypothesized. Both in vivo and in vitro studies revealed that a Cd exposure at environmentally relevant concentrations results in biphasic Cd dose-thyroid response relationships. Development of thyroid tumors following exposure to Cd has been studied mainly using in vitro methodologies. In the thyroid, Cd has been shown to activate or stimulate the activity of various factors, leading to increased cell proliferation and a reduction in normal apoptotic activity. Evidence establishing the association between Cd and thyroid disruption remains ambiguous, with further studies needed to elucidate the issue and improve our understanding of Cd-mediated effects on the thyroid gland.

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Buha A, Matovic V, Antonijevic B, Bulat Z, Curcic M, Renieri EA et al. Overview of cadmium thyroid disrupting effects and mechanisms. International Journal of Molecular Sciences. 2018 May 17;19(5). 1501. https://doi.org/10.3390/ijms19051501