Opioid drug abuse and modulation of immune function: Consequences in the susceptibility to opportunistic infections

Sabita Roy, Jana Ninkovic, Santanu Banerjee, Richard Gene Charboneau, Subhas Das, Raini Dutta, Varvara A. Kirchner, Lisa Koodie, Jing Ma, Jingjing Meng, Roderick A. Barke

Research output: Contribution to journalReview article

109 Citations (Scopus)

Abstract

Infection rate among intravenous drug users (IDU) is higher than the general public, and is the major cause of morbidity and hospitalization in the IDU population. Epidemiologic studies provide data on increased prevalence of opportunistic bacterial infections such as TB and pneumonia, and viral infections such as HIV-1 and hepatitis in the IDU population. An important component in the intravenous drug abuse population and in patients receiving medically indicated chronic opioid treatment is opioid withdrawal. Data on bacterial virulence in the context of opioid withdrawal suggest that mice undergoing withdrawal had shortened survival and increased bacterial load in response to Salmonella infection. As the body of evidence in support of opioid dependency and its immunosuppressive effects is growing, it is imperative to understand the mechanisms by which opioids exert these effects and identify the populations at risk that would benefit the most from the interventions to counteract opioid immunosuppressive effects. Thus, it is important to refine the existing animal model to closely match human conditions and to cross-validate these findings through carefully controlled human studies. Better understanding of the mechanisms will facilitate the search for new therapeutic modalities to counteract adverse effects including increased infection rates. This review will summarize the effects of morphine on innate and adaptive immunity, identify the role of the mu opioid receptor in these functions and the signal transduction activated in the process. The role of opioid withdrawal in immunosuppression and the clinical relevance of these findings will also be discussed.

Original languageEnglish
Pages (from-to)442-465
Number of pages24
JournalJournal of Neuroimmune Pharmacology
Volume6
Issue number4
DOIs
StatePublished - 1 Dec 2011

Fingerprint

Opportunistic Infections
Opioid Analgesics
Substance-Related Disorders
Drug Users
Immunosuppressive Agents
Intravenous Substance Abuse
Population
Bacterial Load
Salmonella Infections
mu Opioid Receptor
Adaptive Immunity
Virus Diseases
Infection
Bacterial Infections
Innate Immunity
Immunosuppression
Morphine
Hepatitis
Virulence
HIV-1

Keywords

  • Immune function
  • Morphine
  • Opioid drug abuse
  • Opportunistic infections

Cite this

Roy, Sabita ; Ninkovic, Jana ; Banerjee, Santanu ; Charboneau, Richard Gene ; Das, Subhas ; Dutta, Raini ; Kirchner, Varvara A. ; Koodie, Lisa ; Ma, Jing ; Meng, Jingjing ; Barke, Roderick A. / Opioid drug abuse and modulation of immune function : Consequences in the susceptibility to opportunistic infections. In: Journal of Neuroimmune Pharmacology. 2011 ; Vol. 6, No. 4. pp. 442-465.
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Roy, S, Ninkovic, J, Banerjee, S, Charboneau, RG, Das, S, Dutta, R, Kirchner, VA, Koodie, L, Ma, J, Meng, J & Barke, RA 2011, 'Opioid drug abuse and modulation of immune function: Consequences in the susceptibility to opportunistic infections', Journal of Neuroimmune Pharmacology, vol. 6, no. 4, pp. 442-465. https://doi.org/10.1007/s11481-011-9292-5

Opioid drug abuse and modulation of immune function : Consequences in the susceptibility to opportunistic infections. / Roy, Sabita; Ninkovic, Jana; Banerjee, Santanu; Charboneau, Richard Gene; Das, Subhas; Dutta, Raini; Kirchner, Varvara A.; Koodie, Lisa; Ma, Jing; Meng, Jingjing; Barke, Roderick A.

In: Journal of Neuroimmune Pharmacology, Vol. 6, No. 4, 01.12.2011, p. 442-465.

Research output: Contribution to journalReview article

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T1 - Opioid drug abuse and modulation of immune function

T2 - Consequences in the susceptibility to opportunistic infections

AU - Roy, Sabita

AU - Ninkovic, Jana

AU - Banerjee, Santanu

AU - Charboneau, Richard Gene

AU - Das, Subhas

AU - Dutta, Raini

AU - Kirchner, Varvara A.

AU - Koodie, Lisa

AU - Ma, Jing

AU - Meng, Jingjing

AU - Barke, Roderick A.

PY - 2011/12/1

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N2 - Infection rate among intravenous drug users (IDU) is higher than the general public, and is the major cause of morbidity and hospitalization in the IDU population. Epidemiologic studies provide data on increased prevalence of opportunistic bacterial infections such as TB and pneumonia, and viral infections such as HIV-1 and hepatitis in the IDU population. An important component in the intravenous drug abuse population and in patients receiving medically indicated chronic opioid treatment is opioid withdrawal. Data on bacterial virulence in the context of opioid withdrawal suggest that mice undergoing withdrawal had shortened survival and increased bacterial load in response to Salmonella infection. As the body of evidence in support of opioid dependency and its immunosuppressive effects is growing, it is imperative to understand the mechanisms by which opioids exert these effects and identify the populations at risk that would benefit the most from the interventions to counteract opioid immunosuppressive effects. Thus, it is important to refine the existing animal model to closely match human conditions and to cross-validate these findings through carefully controlled human studies. Better understanding of the mechanisms will facilitate the search for new therapeutic modalities to counteract adverse effects including increased infection rates. This review will summarize the effects of morphine on innate and adaptive immunity, identify the role of the mu opioid receptor in these functions and the signal transduction activated in the process. The role of opioid withdrawal in immunosuppression and the clinical relevance of these findings will also be discussed.

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