Opioid antinociception in amphibians

Research output: Contribution to journalEditorial

36 Scopus citations


Systemic and spinal administration of opioids produces a behaviorally defined antinociception in a variety of mammalian models. Although endogenous opioid peptides and opioid binding sites are ubiquitous throughout phylogeny, little attention has been paid to the function of endogenous opioid systems(s) or development of nociceptive models in nonmammalian species. Recent work has shown that the amphibian, Rana pipiens, provides an appropriate model for assessment of opioid antinociception and that endogenous opioid systems may likewise modulate the central processing of noxious information in amphibians as well as mammals.

Original languageEnglish
Pages (from-to)959-962
Number of pages4
JournalBrain Research Bulletin
Issue number6
StatePublished - Dec 1988


  • Acetic-acid test
  • Amphibian
  • Analgesia
  • Antinociception
  • Intraspinal
  • Morphine
  • Opioid


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