Nucleus accumbens dopamine differentially mediates the formation and maintenance of monogamous pair bonds

Brandon J. Aragona, Yan Liu, Y. Joy Yu, Tom Curtis, Jacqueline M. Detwiler, Thomas R. Insel, Zuoxin Wang

Research output: Contribution to journalArticle

275 Citations (Scopus)

Abstract

The involvement of dopamine within the nucleus accumbens in the formation and maintenance of pair bonds was assessed in a series of experiments using the monogamous prairie vole. We show that dopamine transmission that promotes pair bond formation occurs within the rostral shell of the nucleus accumbens, but not in its core or caudal shell. Within this specific brain region, D1- and D2-like receptor activation produced opposite effects: D1-like activation prevented pair bond formation, whereas D2-like activation facilitated it. After extended cohabitation with a female, male voles showed behavior indicative of pair bond maintenance - namely, selective aggression towards unfamiliar females. These voles also showed a significant upregulation in nucleus accumbens D1-like receptors, and blockade of these receptors abolished selective aggression. Thus, neuroplastic reorganization of the nucleus accumbens dopamine system is responsible for the enduring nature of monogamous pair bonding. Finally, we show that this system may also contribute to species-specific social organization.

Original languageEnglish
Pages (from-to)133-139
Number of pages7
JournalNature Neuroscience
Volume9
Issue number1
DOIs
StatePublished - 1 Jan 2006

Fingerprint

Pair Bond
Nucleus Accumbens
Arvicolinae
Dopamine
Maintenance
Aggression
Up-Regulation
Brain

Cite this

Aragona, Brandon J. ; Liu, Yan ; Yu, Y. Joy ; Curtis, Tom ; Detwiler, Jacqueline M. ; Insel, Thomas R. ; Wang, Zuoxin. / Nucleus accumbens dopamine differentially mediates the formation and maintenance of monogamous pair bonds. In: Nature Neuroscience. 2006 ; Vol. 9, No. 1. pp. 133-139.
@article{c4ed269a397a4535b756dd603b15c5a3,
title = "Nucleus accumbens dopamine differentially mediates the formation and maintenance of monogamous pair bonds",
abstract = "The involvement of dopamine within the nucleus accumbens in the formation and maintenance of pair bonds was assessed in a series of experiments using the monogamous prairie vole. We show that dopamine transmission that promotes pair bond formation occurs within the rostral shell of the nucleus accumbens, but not in its core or caudal shell. Within this specific brain region, D1- and D2-like receptor activation produced opposite effects: D1-like activation prevented pair bond formation, whereas D2-like activation facilitated it. After extended cohabitation with a female, male voles showed behavior indicative of pair bond maintenance - namely, selective aggression towards unfamiliar females. These voles also showed a significant upregulation in nucleus accumbens D1-like receptors, and blockade of these receptors abolished selective aggression. Thus, neuroplastic reorganization of the nucleus accumbens dopamine system is responsible for the enduring nature of monogamous pair bonding. Finally, we show that this system may also contribute to species-specific social organization.",
author = "Aragona, {Brandon J.} and Yan Liu and Yu, {Y. Joy} and Tom Curtis and Detwiler, {Jacqueline M.} and Insel, {Thomas R.} and Zuoxin Wang",
year = "2006",
month = "1",
day = "1",
doi = "10.1038/nn1613",
language = "English",
volume = "9",
pages = "133--139",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "1",

}

Nucleus accumbens dopamine differentially mediates the formation and maintenance of monogamous pair bonds. / Aragona, Brandon J.; Liu, Yan; Yu, Y. Joy; Curtis, Tom; Detwiler, Jacqueline M.; Insel, Thomas R.; Wang, Zuoxin.

In: Nature Neuroscience, Vol. 9, No. 1, 01.01.2006, p. 133-139.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Nucleus accumbens dopamine differentially mediates the formation and maintenance of monogamous pair bonds

AU - Aragona, Brandon J.

AU - Liu, Yan

AU - Yu, Y. Joy

AU - Curtis, Tom

AU - Detwiler, Jacqueline M.

AU - Insel, Thomas R.

AU - Wang, Zuoxin

PY - 2006/1/1

Y1 - 2006/1/1

N2 - The involvement of dopamine within the nucleus accumbens in the formation and maintenance of pair bonds was assessed in a series of experiments using the monogamous prairie vole. We show that dopamine transmission that promotes pair bond formation occurs within the rostral shell of the nucleus accumbens, but not in its core or caudal shell. Within this specific brain region, D1- and D2-like receptor activation produced opposite effects: D1-like activation prevented pair bond formation, whereas D2-like activation facilitated it. After extended cohabitation with a female, male voles showed behavior indicative of pair bond maintenance - namely, selective aggression towards unfamiliar females. These voles also showed a significant upregulation in nucleus accumbens D1-like receptors, and blockade of these receptors abolished selective aggression. Thus, neuroplastic reorganization of the nucleus accumbens dopamine system is responsible for the enduring nature of monogamous pair bonding. Finally, we show that this system may also contribute to species-specific social organization.

AB - The involvement of dopamine within the nucleus accumbens in the formation and maintenance of pair bonds was assessed in a series of experiments using the monogamous prairie vole. We show that dopamine transmission that promotes pair bond formation occurs within the rostral shell of the nucleus accumbens, but not in its core or caudal shell. Within this specific brain region, D1- and D2-like receptor activation produced opposite effects: D1-like activation prevented pair bond formation, whereas D2-like activation facilitated it. After extended cohabitation with a female, male voles showed behavior indicative of pair bond maintenance - namely, selective aggression towards unfamiliar females. These voles also showed a significant upregulation in nucleus accumbens D1-like receptors, and blockade of these receptors abolished selective aggression. Thus, neuroplastic reorganization of the nucleus accumbens dopamine system is responsible for the enduring nature of monogamous pair bonding. Finally, we show that this system may also contribute to species-specific social organization.

UR - http://www.scopus.com/inward/record.url?scp=29444436968&partnerID=8YFLogxK

U2 - 10.1038/nn1613

DO - 10.1038/nn1613

M3 - Article

C2 - 16327783

AN - SCOPUS:29444436968

VL - 9

SP - 133

EP - 139

JO - Nature Neuroscience

JF - Nature Neuroscience

SN - 1097-6256

IS - 1

ER -