Nonsteroidal Anti-inflammatory Drugs (NSAIDS) Inhibit the Growth and Reproduction of Chaetomium globosum and Other Fungi Associated with Water-Damaged Buildings

Kelsey Dalmont, Charles L. Biles, Heather Konsure, Sujita Dahal, Tyler Rowsey, Matthew Broge, Shubhra Poudyal, Tara Gurung, Sabina Shrestha, Caleb L. Biles, Terry Cluck, Alisha Howard

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    Indoor mold due to water damage causes serious human respiratory disorders, and the remediation to homes, schools, and businesses is a major expense. Prevention of mold infestation of building materials would reduce health problems and building remediation costs. Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit yeasts and a limited number of filamentous fungi. The purpose of this research was to determine the possible inhibitory activity of nonsteroidal anti-inflammatory drugs (NSAIDs) on germination, fungal growth, and reproduction of Chaetomium globosum and other important filamentous fungi that occur in water-damaged buildings. Several NSAIDs were found to inhibit C. globosum germination, growth, and reproduction. The most effective NSAIDs inhibiting C. globosum were ibuprofen, diflunisal, and diclofenac. Fusarium oxysporum, Fusarium solani, Aspergillus niger, and Stachybotrys atra were also tested on the various media with similar results obtained. However, F. oxysporum and A. niger exhibited a higher level of resistance to aspirin and NaSAL when compared to the C. globosum isolates. The inhibition exhibited by NSAIDs was variable depending on growth media and stage of fungal development. These compounds have a great potential of inhibiting fungal growth on building materials such as gypsum board. Formulations of sprays or building materials with NSAID-like chemical treatments may hold promise in reducing mold in homes and buildings.

    Original languageEnglish
    Pages (from-to)1025-1036
    Number of pages12
    JournalMycopathologia
    Volume182
    Issue number11-12
    DOIs
    StatePublished - 1 Dec 2017

    Fingerprint

    Chaetomium
    Chaetomium globosum
    nonsteroidal anti-inflammatory agents
    Reproduction
    Fungi
    Anti-Inflammatory Agents
    fungi
    Water
    Growth
    Pharmaceutical Preparations
    molds (fungi)
    Aspergillus niger
    water
    Fusarium
    remediation
    Germination
    Fusarium oxysporum
    microbial growth
    Stachybotrys chartarum
    Stachybotrys

    Keywords

    • Acetaminophen
    • Aspergillus niger
    • Chaetomium sp
    • Fungal inhibition
    • Fusarium oxysporum
    • Fusarium solani
    • Hyphal growth
    • Mold
    • NSAIDs
    • Perithecia synthesis
    • Spore germination
    • Stachybotrys atra
    • Water-damaged buildings

    Cite this

    Dalmont, Kelsey ; Biles, Charles L. ; Konsure, Heather ; Dahal, Sujita ; Rowsey, Tyler ; Broge, Matthew ; Poudyal, Shubhra ; Gurung, Tara ; Shrestha, Sabina ; Biles, Caleb L. ; Cluck, Terry ; Howard, Alisha. / Nonsteroidal Anti-inflammatory Drugs (NSAIDS) Inhibit the Growth and Reproduction of Chaetomium globosum and Other Fungi Associated with Water-Damaged Buildings. In: Mycopathologia. 2017 ; Vol. 182, No. 11-12. pp. 1025-1036.
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    abstract = "Indoor mold due to water damage causes serious human respiratory disorders, and the remediation to homes, schools, and businesses is a major expense. Prevention of mold infestation of building materials would reduce health problems and building remediation costs. Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit yeasts and a limited number of filamentous fungi. The purpose of this research was to determine the possible inhibitory activity of nonsteroidal anti-inflammatory drugs (NSAIDs) on germination, fungal growth, and reproduction of Chaetomium globosum and other important filamentous fungi that occur in water-damaged buildings. Several NSAIDs were found to inhibit C. globosum germination, growth, and reproduction. The most effective NSAIDs inhibiting C. globosum were ibuprofen, diflunisal, and diclofenac. Fusarium oxysporum, Fusarium solani, Aspergillus niger, and Stachybotrys atra were also tested on the various media with similar results obtained. However, F. oxysporum and A. niger exhibited a higher level of resistance to aspirin and NaSAL when compared to the C. globosum isolates. The inhibition exhibited by NSAIDs was variable depending on growth media and stage of fungal development. These compounds have a great potential of inhibiting fungal growth on building materials such as gypsum board. Formulations of sprays or building materials with NSAID-like chemical treatments may hold promise in reducing mold in homes and buildings.",
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    author = "Kelsey Dalmont and Biles, {Charles L.} and Heather Konsure and Sujita Dahal and Tyler Rowsey and Matthew Broge and Shubhra Poudyal and Tara Gurung and Sabina Shrestha and Biles, {Caleb L.} and Terry Cluck and Alisha Howard",
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    Dalmont, K, Biles, CL, Konsure, H, Dahal, S, Rowsey, T, Broge, M, Poudyal, S, Gurung, T, Shrestha, S, Biles, CL, Cluck, T & Howard, A 2017, 'Nonsteroidal Anti-inflammatory Drugs (NSAIDS) Inhibit the Growth and Reproduction of Chaetomium globosum and Other Fungi Associated with Water-Damaged Buildings', Mycopathologia, vol. 182, no. 11-12, pp. 1025-1036. https://doi.org/10.1007/s11046-017-0188-7

    Nonsteroidal Anti-inflammatory Drugs (NSAIDS) Inhibit the Growth and Reproduction of Chaetomium globosum and Other Fungi Associated with Water-Damaged Buildings. / Dalmont, Kelsey; Biles, Charles L.; Konsure, Heather; Dahal, Sujita; Rowsey, Tyler; Broge, Matthew; Poudyal, Shubhra; Gurung, Tara; Shrestha, Sabina; Biles, Caleb L.; Cluck, Terry; Howard, Alisha.

    In: Mycopathologia, Vol. 182, No. 11-12, 01.12.2017, p. 1025-1036.

    Research output: Contribution to journalArticle

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    AU - Dalmont, Kelsey

    AU - Biles, Charles L.

    AU - Konsure, Heather

    AU - Dahal, Sujita

    AU - Rowsey, Tyler

    AU - Broge, Matthew

    AU - Poudyal, Shubhra

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    AU - Shrestha, Sabina

    AU - Biles, Caleb L.

    AU - Cluck, Terry

    AU - Howard, Alisha

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    N2 - Indoor mold due to water damage causes serious human respiratory disorders, and the remediation to homes, schools, and businesses is a major expense. Prevention of mold infestation of building materials would reduce health problems and building remediation costs. Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit yeasts and a limited number of filamentous fungi. The purpose of this research was to determine the possible inhibitory activity of nonsteroidal anti-inflammatory drugs (NSAIDs) on germination, fungal growth, and reproduction of Chaetomium globosum and other important filamentous fungi that occur in water-damaged buildings. Several NSAIDs were found to inhibit C. globosum germination, growth, and reproduction. The most effective NSAIDs inhibiting C. globosum were ibuprofen, diflunisal, and diclofenac. Fusarium oxysporum, Fusarium solani, Aspergillus niger, and Stachybotrys atra were also tested on the various media with similar results obtained. However, F. oxysporum and A. niger exhibited a higher level of resistance to aspirin and NaSAL when compared to the C. globosum isolates. The inhibition exhibited by NSAIDs was variable depending on growth media and stage of fungal development. These compounds have a great potential of inhibiting fungal growth on building materials such as gypsum board. Formulations of sprays or building materials with NSAID-like chemical treatments may hold promise in reducing mold in homes and buildings.

    AB - Indoor mold due to water damage causes serious human respiratory disorders, and the remediation to homes, schools, and businesses is a major expense. Prevention of mold infestation of building materials would reduce health problems and building remediation costs. Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit yeasts and a limited number of filamentous fungi. The purpose of this research was to determine the possible inhibitory activity of nonsteroidal anti-inflammatory drugs (NSAIDs) on germination, fungal growth, and reproduction of Chaetomium globosum and other important filamentous fungi that occur in water-damaged buildings. Several NSAIDs were found to inhibit C. globosum germination, growth, and reproduction. The most effective NSAIDs inhibiting C. globosum were ibuprofen, diflunisal, and diclofenac. Fusarium oxysporum, Fusarium solani, Aspergillus niger, and Stachybotrys atra were also tested on the various media with similar results obtained. However, F. oxysporum and A. niger exhibited a higher level of resistance to aspirin and NaSAL when compared to the C. globosum isolates. The inhibition exhibited by NSAIDs was variable depending on growth media and stage of fungal development. These compounds have a great potential of inhibiting fungal growth on building materials such as gypsum board. Formulations of sprays or building materials with NSAID-like chemical treatments may hold promise in reducing mold in homes and buildings.

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