Nonmammalian models for the study of pain

Craig W. Stevens

doi:10.1007/978-1-59745-285-4_37

Nonmammalian models for the study of pain

Craig W. Stevens

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

11 Scopus citations

Abstract

Processing nociceptive information is a consistent feature of the nervous system in all vertebrate species. This chapter reviews the nonmammalian models developed for pain and analgesia research, with a special emphasis on models that were used for detecting opioid antinociception. Nociceptive pathways in nonmammalian vertebrates are reviewed and endogenous opioid systems are described. Compared to mammalian models for pain research, there are relatively few models in each vertebrate class. Details are provided for the methods and the results of using an amphibian model for the testing of opioid analgesics. The chapter ends with a case study of the comparative approach in pain and analgesia research applied to the molecular evolution of opioid receptor proteins.

Original language	English
Title of host publication	Source Book of Models for Biomedical Research
Publisher	Humana Press
Pages	341-352
Number of pages	12
ISBN (Print)	9781588299338
DOIs	https://doi.org/10.1007/978-1-59745-285-4_37
State	Published - 2008

Keywords

Amphibians
Analgesia
Animal models
Evolution
Opioids
Pain

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10.1007/978-1-59745-285-4_37

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AB - Processing nociceptive information is a consistent feature of the nervous system in all vertebrate species. This chapter reviews the nonmammalian models developed for pain and analgesia research, with a special emphasis on models that were used for detecting opioid antinociception. Nociceptive pathways in nonmammalian vertebrates are reviewed and endogenous opioid systems are described. Compared to mammalian models for pain research, there are relatively few models in each vertebrate class. Details are provided for the methods and the results of using an amphibian model for the testing of opioid analgesics. The chapter ends with a case study of the comparative approach in pain and analgesia research applied to the molecular evolution of opioid receptor proteins.

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ER -

Nonmammalian models for the study of pain

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