New Geranyl Stilbenes from Dalea purpurea with in Vitro Opioid Receptor Affinity

Gil Belofsky, April N. French, David Wallace, Summer L. Dodson

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Three new geranyl stilbenes, pawhuskins A, B, and C (1, 2, and 3), were isolated from organic extracts of Dalea purpurea. The structures of the three compounds were determined by NMR and HRMS methods. The activities of these compounds, along with that of the known compound petalostemumol (4), were evaluated in an opioid receptor assay in vitro. Pawhuskin A (1) exhibited the strongest activity of the four compounds with a Ki value of 0.29 ± 0.11 μM.

Original languageEnglish
Pages (from-to)26-30
Number of pages5
JournalJournal of Natural Products
Volume67
Issue number1
DOIs
StatePublished - 1 Jan 2004

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Dalea purpurea
Stilbenes
stilbenes
narcotics
Opioid Receptors
receptors
extracts
assays
Assays
Nuclear magnetic resonance
methodology
pawhuskin A
In Vitro Techniques

Cite this

Belofsky, Gil ; French, April N. ; Wallace, David ; Dodson, Summer L. / New Geranyl Stilbenes from Dalea purpurea with in Vitro Opioid Receptor Affinity. In: Journal of Natural Products. 2004 ; Vol. 67, No. 1. pp. 26-30.
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New Geranyl Stilbenes from Dalea purpurea with in Vitro Opioid Receptor Affinity. / Belofsky, Gil; French, April N.; Wallace, David; Dodson, Summer L.

In: Journal of Natural Products, Vol. 67, No. 1, 01.01.2004, p. 26-30.

Research output: Contribution to journalArticle

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