New Geranyl Stilbenes from Dalea purpurea with in Vitro Opioid Receptor Affinity

Gil Belofsky, April N. French, David R. Wallace, Summer L. Dodson

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Three new geranyl stilbenes, pawhuskins A, B, and C (1, 2, and 3), were isolated from organic extracts of Dalea purpurea. The structures of the three compounds were determined by NMR and HRMS methods. The activities of these compounds, along with that of the known compound petalostemumol (4), were evaluated in an opioid receptor assay in vitro. Pawhuskin A (1) exhibited the strongest activity of the four compounds with a Ki value of 0.29 ± 0.11 μM.

Original languageEnglish
Pages (from-to)26-30
Number of pages5
JournalJournal of Natural Products
Issue number1
StatePublished - 1 Jan 2004


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