New Geranyl Stilbenes from Dalea purpurea with in Vitro Opioid Receptor Affinity

Gil Belofsky; April N. French; David R. Wallace; Summer L. Dodson

doi:10.1021/np030258d

New Geranyl Stilbenes from Dalea purpurea with in Vitro Opioid Receptor Affinity

Gil Belofsky, April N. French, David R. Wallace, Summer L. Dodson

Pharmacology and Physiology

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Three new geranyl stilbenes, pawhuskins A, B, and C (1, 2, and 3), were isolated from organic extracts of Dalea purpurea. The structures of the three compounds were determined by NMR and HRMS methods. The activities of these compounds, along with that of the known compound petalostemumol (4), were evaluated in an opioid receptor assay in vitro. Pawhuskin A (1) exhibited the strongest activity of the four compounds with a K_i value of 0.29 ± 0.11 μM.

Original language	English
Pages (from-to)	26-30
Number of pages	5
Journal	Journal of Natural Products
Volume	67
Issue number	1
DOIs	https://doi.org/10.1021/np030258d
State	Published - Jan 2004

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10.1021/np030258d

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abstract = "Three new geranyl stilbenes, pawhuskins A, B, and C (1, 2, and 3), were isolated from organic extracts of Dalea purpurea. The structures of the three compounds were determined by NMR and HRMS methods. The activities of these compounds, along with that of the known compound petalostemumol (4), were evaluated in an opioid receptor assay in vitro. Pawhuskin A (1) exhibited the strongest activity of the four compounds with a Ki value of 0.29 ± 0.11 μM.",

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AU - Dodson, Summer L.

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AB - Three new geranyl stilbenes, pawhuskins A, B, and C (1, 2, and 3), were isolated from organic extracts of Dalea purpurea. The structures of the three compounds were determined by NMR and HRMS methods. The activities of these compounds, along with that of the known compound petalostemumol (4), were evaluated in an opioid receptor assay in vitro. Pawhuskin A (1) exhibited the strongest activity of the four compounds with a Ki value of 0.29 ± 0.11 μM.

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New Geranyl Stilbenes from Dalea purpurea with in Vitro Opioid Receptor Affinity

Abstract

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