Neuroimmunometabolism: A New Pathological Nexus Underlying Neurodegenerative Disorders

Swarup Mitra, Avijit Banik, Sumit Saurabh, Malabika Maulik, Shailesh N. Khatri

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

Neuroimmunometabolism is an emerging field that examines the intersection of immunologic and metabolic cascades in the brain. Neuroinflammatory conditions often involve differential metabolic reprogramming in neuronal and glial cells through their immunometabolic sensors. The impact of such bioenergetic adaptation on general brain function is poorly understood, but this cross-talk becomes increasingly important in neurodegenerative disorders that exhibit reshaping of neuroimmunometabolic pathways. Here we summarize the intrinsic balance of neuroimmunometabolic substrates and sensors in the healthy brain and how their dysregulation can contribute to the pathophysiology of various neurodegenerative disorders. This review also proposes possible avenues for disease management through neuroimmunometabolic profiling and therapeutics to bridge translational gaps and guide future treatment strategies.

Original languageEnglish
Pages (from-to)1888-1907
Number of pages20
JournalJournal of Neuroscience
Volume42
Issue number10
DOIs
StatePublished - 9 Mar 2022

Keywords

  • immunometabolic sensors
  • neurodegeneration
  • neuroimmunometabolism
  • neuroinflammation

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