Neurodevelopment: Inflammation Matters

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

4 Scopus citations

Abstract

There is substantial evidence demonstrating an association between inflammation and neurodevelopmental disorders, including cerebral palsy, autism spectrum disorder, and schizophrenia. Preclinical studies in animal models have provided critical insights into the role of inflammation in neurodevelopment, yet, there remains much to discover in terms of the molecular and cellular mechanisms involved. This chapter provides a review of key epidemiological and clinical evidence for the role of inflammation in neurodevelopment as well as mechanistic insights from preclinical studies. The focus will be on the impact of maternal/perinatal inflammation on neuroinflammation, brain injury, and behavioral deficits in the affected offspring, with a particular emphasis on the most recent findings in the literature. Finally, there will be a discussion of potential therapeutic strategies to prevent/reduce inflammation-mediated disruptions in neurodevelopment.

Original languageEnglish
Title of host publicationLinking Environmental Exposure to Neurodevelopmental Disorders
PublisherElsevier Inc.
Pages227-264
Number of pages38
DOIs
StatePublished - Jan 2018

Publication series

NameAdvances in Neurotoxicology
Volume2
ISSN (Electronic)2468-7480

Keywords

  • Astrocytes
  • Autism spectrum disorder
  • Cerebral palsy
  • Maternal immune activation
  • Microglia
  • Neuroinflammation
  • Oligodendrocytes
  • Perinatal inflammation
  • Schizophrenia
  • White matter injury

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