Naloxone blocks the analgesic action of levorphanol but not of dextrorphan in the leopard frog

Craig Stevens, Paul D. Pezalla

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Intraspinal injection of levorphanol (3 μg) at the lumbar area of the leopard frog, Rana pipiens, induced analgesia which was completely blocked by co-injection of naloxone (3 μg), whereas dextrorphan (3 μg) induced analgesia which was unaffected by naloxone. Subcutaneous levorphanol (20 or 80 mg/kg) induced a dose-dependent analgesia which was blocked by concurrent naloxone (2 mg/kg), while only the higher dose of dextrorphan (80 mg/kg) induced analgesia which was unaffected by concurrent naloxone at 8 or 80 mg/kg. These data are the first to indicate naloxone-insensitive, dextrorphan-induced analgesia.

Original languageEnglish
Pages (from-to)171-174
Number of pages4
JournalBrain Research
Volume301
Issue number1
DOIs
StatePublished - 28 May 1984

Fingerprint

Levorphanol
Dextrorphan
Rana pipiens
Naloxone
Analgesia
Analgesics
Spinal Injections
Injections

Keywords

  • amphibians
  • analgesia
  • dextrorphan
  • levorphanol
  • naloxone
  • μ-opiate receptor
  • σ-opiate receptor

Cite this

@article{0ae7efbc95b34d63a852d29d631a3a0c,
title = "Naloxone blocks the analgesic action of levorphanol but not of dextrorphan in the leopard frog",
abstract = "Intraspinal injection of levorphanol (3 μg) at the lumbar area of the leopard frog, Rana pipiens, induced analgesia which was completely blocked by co-injection of naloxone (3 μg), whereas dextrorphan (3 μg) induced analgesia which was unaffected by naloxone. Subcutaneous levorphanol (20 or 80 mg/kg) induced a dose-dependent analgesia which was blocked by concurrent naloxone (2 mg/kg), while only the higher dose of dextrorphan (80 mg/kg) induced analgesia which was unaffected by concurrent naloxone at 8 or 80 mg/kg. These data are the first to indicate naloxone-insensitive, dextrorphan-induced analgesia.",
keywords = "amphibians, analgesia, dextrorphan, levorphanol, naloxone, μ-opiate receptor, σ-opiate receptor",
author = "Craig Stevens and Pezalla, {Paul D.}",
year = "1984",
month = "5",
day = "28",
doi = "10.1016/0006-8993(84)90418-9",
language = "English",
volume = "301",
pages = "171--174",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1",

}

Naloxone blocks the analgesic action of levorphanol but not of dextrorphan in the leopard frog. / Stevens, Craig; Pezalla, Paul D.

In: Brain Research, Vol. 301, No. 1, 28.05.1984, p. 171-174.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Naloxone blocks the analgesic action of levorphanol but not of dextrorphan in the leopard frog

AU - Stevens, Craig

AU - Pezalla, Paul D.

PY - 1984/5/28

Y1 - 1984/5/28

N2 - Intraspinal injection of levorphanol (3 μg) at the lumbar area of the leopard frog, Rana pipiens, induced analgesia which was completely blocked by co-injection of naloxone (3 μg), whereas dextrorphan (3 μg) induced analgesia which was unaffected by naloxone. Subcutaneous levorphanol (20 or 80 mg/kg) induced a dose-dependent analgesia which was blocked by concurrent naloxone (2 mg/kg), while only the higher dose of dextrorphan (80 mg/kg) induced analgesia which was unaffected by concurrent naloxone at 8 or 80 mg/kg. These data are the first to indicate naloxone-insensitive, dextrorphan-induced analgesia.

AB - Intraspinal injection of levorphanol (3 μg) at the lumbar area of the leopard frog, Rana pipiens, induced analgesia which was completely blocked by co-injection of naloxone (3 μg), whereas dextrorphan (3 μg) induced analgesia which was unaffected by naloxone. Subcutaneous levorphanol (20 or 80 mg/kg) induced a dose-dependent analgesia which was blocked by concurrent naloxone (2 mg/kg), while only the higher dose of dextrorphan (80 mg/kg) induced analgesia which was unaffected by concurrent naloxone at 8 or 80 mg/kg. These data are the first to indicate naloxone-insensitive, dextrorphan-induced analgesia.

KW - amphibians

KW - analgesia

KW - dextrorphan

KW - levorphanol

KW - naloxone

KW - μ-opiate receptor

KW - σ-opiate receptor

UR - http://www.scopus.com/inward/record.url?scp=0021354259&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(84)90418-9

DO - 10.1016/0006-8993(84)90418-9

M3 - Article

C2 - 6329442

AN - SCOPUS:0021354259

VL - 301

SP - 171

EP - 174

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1

ER -