Molecular and physicochemical aspects of local anesthetics acting on nicotinic acetylcholine receptor-containing membranes.

Hugo R. Arias, Michael P. Blanton

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Local anesthetics inhibit the ion channel activity of nicotinic acetylcholine receptors in a noncompetitive fashion. This inhibitory action is ascribed to two possible inhibitory mechanisms: an open-channel-blocking mechanism and/or an allosteric process where the drug binds either to the closed channel or to other nonluminal sites, respectively.

Original languageEnglish
Pages (from-to)385-410
Number of pages26
JournalMini reviews in medicinal chemistry
Volume2
Issue number4
DOIs
StatePublished - 1 Jan 2002
Externally publishedYes

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Nicotinic Receptors
Local Anesthetics
Ion Channels
Membranes
Pharmaceutical Preparations

Cite this

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Molecular and physicochemical aspects of local anesthetics acting on nicotinic acetylcholine receptor-containing membranes. / Arias, Hugo R.; Blanton, Michael P.

In: Mini reviews in medicinal chemistry, Vol. 2, No. 4, 01.01.2002, p. 385-410.

Research output: Contribution to journalReview article

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