Molecular and physicochemical aspects of local anesthetics acting on nicotinic acetylcholine receptor-containing membranes.

Hugo R. Arias, Michael P. Blanton

Research output: Contribution to journalReview article

13 Scopus citations

Abstract

Local anesthetics inhibit the ion channel activity of nicotinic acetylcholine receptors in a noncompetitive fashion. This inhibitory action is ascribed to two possible inhibitory mechanisms: an open-channel-blocking mechanism and/or an allosteric process where the drug binds either to the closed channel or to other nonluminal sites, respectively.

Original languageEnglish
Pages (from-to)385-410
Number of pages26
JournalMini reviews in medicinal chemistry
Volume2
Issue number4
DOIs
StatePublished - 1 Jan 2002
Externally publishedYes

Fingerprint Dive into the research topics of 'Molecular and physicochemical aspects of local anesthetics acting on nicotinic acetylcholine receptor-containing membranes.'. Together they form a unique fingerprint.

  • Cite this