Molecular and physicochemical aspects of local anesthetics acting on nicotinic acetylcholine receptor-containing membranes.

Hugo R. Arias; Michael P. Blanton

doi:10.2174/1389557023406025

Molecular and physicochemical aspects of local anesthetics acting on nicotinic acetylcholine receptor-containing membranes.

Hugo R. Arias, Michael P. Blanton

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

Local anesthetics inhibit the ion channel activity of nicotinic acetylcholine receptors in a noncompetitive fashion. This inhibitory action is ascribed to two possible inhibitory mechanisms: an open-channel-blocking mechanism and/or an allosteric process where the drug binds either to the closed channel or to other nonluminal sites, respectively.

Original language	English
Pages (from-to)	385-410
Number of pages	26
Journal	Mini reviews in medicinal chemistry
Volume	2
Issue number	4
DOIs	https://doi.org/10.2174/1389557023406025
State	Published - 1 Jan 2002
Externally published	Yes

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title = "Molecular and physicochemical aspects of local anesthetics acting on nicotinic acetylcholine receptor-containing membranes.",

abstract = "Local anesthetics inhibit the ion channel activity of nicotinic acetylcholine receptors in a noncompetitive fashion. This inhibitory action is ascribed to two possible inhibitory mechanisms: an open-channel-blocking mechanism and/or an allosteric process where the drug binds either to the closed channel or to other nonluminal sites, respectively.",

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AU - Blanton, Michael P.

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N2 - Local anesthetics inhibit the ion channel activity of nicotinic acetylcholine receptors in a noncompetitive fashion. This inhibitory action is ascribed to two possible inhibitory mechanisms: an open-channel-blocking mechanism and/or an allosteric process where the drug binds either to the closed channel or to other nonluminal sites, respectively.

AB - Local anesthetics inhibit the ion channel activity of nicotinic acetylcholine receptors in a noncompetitive fashion. This inhibitory action is ascribed to two possible inhibitory mechanisms: an open-channel-blocking mechanism and/or an allosteric process where the drug binds either to the closed channel or to other nonluminal sites, respectively.

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M3 - Review article

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JO - Mini reviews in medicinal chemistry

JF - Mini reviews in medicinal chemistry

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Molecular and physicochemical aspects of local anesthetics acting on nicotinic acetylcholine receptor-containing membranes.

Abstract

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