MinK-related peptide 1: A beta subunit for the HCN ion channel subunit family enhances expression and speeds activation.

H. Yu; J. Wu; I. Potapova; R. T. Wymore; B. Holmes; J. Zuckerman; Z. Pan; H. Wang; W. Shi; R. B. Robinson; M. R. El-Maghrabi; W. Benjamin; J. Dixon; D. McKinnon; I. S. Cohen; R. Wymore

MinK-related peptide 1: A beta subunit for the HCN ion channel subunit family enhances expression and speeds activation.

H. Yu, J. Wu, I. Potapova, R. T. Wymore, B. Holmes, J. Zuckerman, Z. Pan, H. Wang, W. Shi, R. B. Robinson, M. R. El-Maghrabi, W. Benjamin, J. Dixon, D. McKinnon, I. S. Cohen, R. Wymore

Pharmacology and Physiology

Research output: Contribution to journal › Article › peer-review

212 Scopus citations

Abstract

The HCN family of ion channel subunits underlies the currents I(f) in heart and I(h) and I(q) in the nervous system. In the present study, we demonstrate that minK-related peptide 1 (MiRP1) is a beta subunit for the HCN family. As such, it enhances protein and current expression as well as accelerating the kinetics of activation. Because MiRP1 also functions as a beta subunit for the cardiac delayed rectifier I(Kr), these results suggest that this peptide may have the unique role of regulating both the inward and outward channels that underlie cardiac pacemaker activity. The full text of this article is available at http://www.circresaha.org.

Original language	English
Pages (from-to)	E84-87
Journal	Circulation Research
Volume	88
Issue number	12
State	Published - 22 Jun 2001

Cite this

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title = "MinK-related peptide 1: A beta subunit for the HCN ion channel subunit family enhances expression and speeds activation.",

abstract = "The HCN family of ion channel subunits underlies the currents I(f) in heart and I(h) and I(q) in the nervous system. In the present study, we demonstrate that minK-related peptide 1 (MiRP1) is a beta subunit for the HCN family. As such, it enhances protein and current expression as well as accelerating the kinetics of activation. Because MiRP1 also functions as a beta subunit for the cardiac delayed rectifier I(Kr), these results suggest that this peptide may have the unique role of regulating both the inward and outward channels that underlie cardiac pacemaker activity. The full text of this article is available at http://www.circresaha.org.",

author = "H. Yu and J. Wu and I. Potapova and Wymore, {R. T.} and B. Holmes and J. Zuckerman and Z. Pan and H. Wang and W. Shi and Robinson, {R. B.} and El-Maghrabi, {M. R.} and W. Benjamin and J. Dixon and D. McKinnon and Cohen, {I. S.} and R. Wymore",

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month = jun,

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language = "English",

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pages = "E84--87",

journal = "Circulation Research",

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TY - JOUR

T1 - MinK-related peptide 1

T2 - A beta subunit for the HCN ion channel subunit family enhances expression and speeds activation.

AU - Yu, H.

AU - Wu, J.

AU - Potapova, I.

AU - Wymore, R. T.

AU - Holmes, B.

AU - Zuckerman, J.

AU - Pan, Z.

AU - Wang, H.

AU - Shi, W.

AU - Robinson, R. B.

AU - El-Maghrabi, M. R.

AU - Benjamin, W.

AU - Dixon, J.

AU - McKinnon, D.

AU - Cohen, I. S.

AU - Wymore, R.

PY - 2001/6/22

Y1 - 2001/6/22

N2 - The HCN family of ion channel subunits underlies the currents I(f) in heart and I(h) and I(q) in the nervous system. In the present study, we demonstrate that minK-related peptide 1 (MiRP1) is a beta subunit for the HCN family. As such, it enhances protein and current expression as well as accelerating the kinetics of activation. Because MiRP1 also functions as a beta subunit for the cardiac delayed rectifier I(Kr), these results suggest that this peptide may have the unique role of regulating both the inward and outward channels that underlie cardiac pacemaker activity. The full text of this article is available at http://www.circresaha.org.

AB - The HCN family of ion channel subunits underlies the currents I(f) in heart and I(h) and I(q) in the nervous system. In the present study, we demonstrate that minK-related peptide 1 (MiRP1) is a beta subunit for the HCN family. As such, it enhances protein and current expression as well as accelerating the kinetics of activation. Because MiRP1 also functions as a beta subunit for the cardiac delayed rectifier I(Kr), these results suggest that this peptide may have the unique role of regulating both the inward and outward channels that underlie cardiac pacemaker activity. The full text of this article is available at http://www.circresaha.org.

UR - http://www.scopus.com/inward/record.url?scp=0010244063&partnerID=8YFLogxK

M3 - Article

C2 - 11420311

AN - SCOPUS:0010244063

SN - 0009-7330

VL - 88

SP - E84-87

JO - Circulation Research

JF - Circulation Research

IS - 12

ER -

MinK-related peptide 1: A beta subunit for the HCN ion channel subunit family enhances expression and speeds activation.

Abstract

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