MinK-related peptide 1: A beta subunit for the HCN ion channel subunit family enhances expression and speeds activation.

H. Yu, J. Wu, I. Potapova, R. T. Wymore, B. Holmes, J. Zuckerman, Z. Pan, H. Wang, W. Shi, R. B. Robinson, M. R. El-Maghrabi, W. Benjamin, J. Dixon, D. McKinnon, I. S. Cohen, R. Wymore

Research output: Contribution to journalArticle

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Abstract

The HCN family of ion channel subunits underlies the currents I(f) in heart and I(h) and I(q) in the nervous system. In the present study, we demonstrate that minK-related peptide 1 (MiRP1) is a beta subunit for the HCN family. As such, it enhances protein and current expression as well as accelerating the kinetics of activation. Because MiRP1 also functions as a beta subunit for the cardiac delayed rectifier I(Kr), these results suggest that this peptide may have the unique role of regulating both the inward and outward channels that underlie cardiac pacemaker activity. The full text of this article is available at http://www.circresaha.org.

Original languageEnglish
Pages (from-to)E84-87
JournalCirculation Research
Volume88
Issue number12
StatePublished - 22 Jun 2001

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Ion Channels
Peptides
Nervous System
Proteins

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Yu, H. ; Wu, J. ; Potapova, I. ; Wymore, R. T. ; Holmes, B. ; Zuckerman, J. ; Pan, Z. ; Wang, H. ; Shi, W. ; Robinson, R. B. ; El-Maghrabi, M. R. ; Benjamin, W. ; Dixon, J. ; McKinnon, D. ; Cohen, I. S. ; Wymore, R. / MinK-related peptide 1 : A beta subunit for the HCN ion channel subunit family enhances expression and speeds activation. In: Circulation Research. 2001 ; Vol. 88, No. 12. pp. E84-87.
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abstract = "The HCN family of ion channel subunits underlies the currents I(f) in heart and I(h) and I(q) in the nervous system. In the present study, we demonstrate that minK-related peptide 1 (MiRP1) is a beta subunit for the HCN family. As such, it enhances protein and current expression as well as accelerating the kinetics of activation. Because MiRP1 also functions as a beta subunit for the cardiac delayed rectifier I(Kr), these results suggest that this peptide may have the unique role of regulating both the inward and outward channels that underlie cardiac pacemaker activity. The full text of this article is available at http://www.circresaha.org.",
author = "H. Yu and J. Wu and I. Potapova and Wymore, {R. T.} and B. Holmes and J. Zuckerman and Z. Pan and H. Wang and W. Shi and Robinson, {R. B.} and El-Maghrabi, {M. R.} and W. Benjamin and J. Dixon and D. McKinnon and Cohen, {I. S.} and R. Wymore",
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Yu, H, Wu, J, Potapova, I, Wymore, RT, Holmes, B, Zuckerman, J, Pan, Z, Wang, H, Shi, W, Robinson, RB, El-Maghrabi, MR, Benjamin, W, Dixon, J, McKinnon, D, Cohen, IS & Wymore, R 2001, 'MinK-related peptide 1: A beta subunit for the HCN ion channel subunit family enhances expression and speeds activation.', Circulation Research, vol. 88, no. 12, pp. E84-87.

MinK-related peptide 1 : A beta subunit for the HCN ion channel subunit family enhances expression and speeds activation. / Yu, H.; Wu, J.; Potapova, I.; Wymore, R. T.; Holmes, B.; Zuckerman, J.; Pan, Z.; Wang, H.; Shi, W.; Robinson, R. B.; El-Maghrabi, M. R.; Benjamin, W.; Dixon, J.; McKinnon, D.; Cohen, I. S.; Wymore, R.

In: Circulation Research, Vol. 88, No. 12, 22.06.2001, p. E84-87.

Research output: Contribution to journalArticle

TY - JOUR

T1 - MinK-related peptide 1

T2 - A beta subunit for the HCN ion channel subunit family enhances expression and speeds activation.

AU - Yu, H.

AU - Wu, J.

AU - Potapova, I.

AU - Wymore, R. T.

AU - Holmes, B.

AU - Zuckerman, J.

AU - Pan, Z.

AU - Wang, H.

AU - Shi, W.

AU - Robinson, R. B.

AU - El-Maghrabi, M. R.

AU - Benjamin, W.

AU - Dixon, J.

AU - McKinnon, D.

AU - Cohen, I. S.

AU - Wymore, R.

PY - 2001/6/22

Y1 - 2001/6/22

N2 - The HCN family of ion channel subunits underlies the currents I(f) in heart and I(h) and I(q) in the nervous system. In the present study, we demonstrate that minK-related peptide 1 (MiRP1) is a beta subunit for the HCN family. As such, it enhances protein and current expression as well as accelerating the kinetics of activation. Because MiRP1 also functions as a beta subunit for the cardiac delayed rectifier I(Kr), these results suggest that this peptide may have the unique role of regulating both the inward and outward channels that underlie cardiac pacemaker activity. The full text of this article is available at http://www.circresaha.org.

AB - The HCN family of ion channel subunits underlies the currents I(f) in heart and I(h) and I(q) in the nervous system. In the present study, we demonstrate that minK-related peptide 1 (MiRP1) is a beta subunit for the HCN family. As such, it enhances protein and current expression as well as accelerating the kinetics of activation. Because MiRP1 also functions as a beta subunit for the cardiac delayed rectifier I(Kr), these results suggest that this peptide may have the unique role of regulating both the inward and outward channels that underlie cardiac pacemaker activity. The full text of this article is available at http://www.circresaha.org.

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