Microvilli and cell-cell fusion during fertilization

Nedra F. Wilson, William J. Snell

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

A number of fundamental biological processes, ranging from fertilization and embryonic development to viral infection, depend upon a complex interplay between cells that results in the fusion of their plasma membranes. Surprisingly, the cellular and molecular mechanisms underlying cell-cell fusion remain largely unknown. Here, the authors discuss evidence suggesting that microvilli play a central role in fusion of many cells and present features of these actin-filled, a cell-surface protrusions that might make them particularly well suited as cell-fusion organelles.

Original languageEnglish
Pages (from-to)93-96
Number of pages4
JournalTrends in Cell Biology
Volume8
Issue number3
DOIs
Publication statusPublished - Mar 1998

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