Maximal cardiorespiratory responses to one- and two-legged cycling during acute and long-term exposure to 4300 meters altitude

Charles S. Fulco, Paul B. Rock, Laurie Trad, Vincent Forte, Allen Cymerman

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

During exposure to altitudes greater than about 2200 m, maximal oxygen uptake ( {Mathematical expression}) is immediately diminished in proportion to the reduction in the partial pressure of oxygen in the inspired air. If the exposure lasts longer than a couple of days, an increase in arterial oxygen content (CaO2), due to a hemoconcentration and an increase in arterial oxygen saturation, occurs. However, there is also a reduction in maximal cardiac output ( {Mathematical expression}) at altitude which offsets the increase in CaO2 and, therefore, {Mathematical expression} does not improve. The purpose of this investigation was to study the contribution of the increase in CaO2 to the working muscles without the potentially confounding problem of a reduced {Mathematical expression}. The approach used was to have seven male subjects (aged 17 to 24 years) perform one- and two-legged {Mathematical expression} tests on a cycle ergometer at sea level (SL, PIO2 = 159 Torr), after 1 h at 4300 m simulated altitude (SA, PIO2 = 94 Torr) and during two weeks of residence on the summit of Pikes Peak, CO. (pP, 4300 m, PIO2 = 94 Torr). Cardiac output limits maximal performance during two-legged cycling but does not limit performance during one-legged cycling. During the study, CaO2 changed from 189±3 (mean ±SE) at SL to 161±4 ml·L-1 during SA (SL vs. SA, p<0.01) and to 200±6 ml·L-1 at PP (SL vs. PP, p<0.05; SA vs. PP, p<0.01). Two-legged {Mathematical expression} decreased from 3.64±0.26 L·min-1 at SL to 2.70±0.14 L·min-1 during SA (p<0.01) to 2.86±0.16 L·min-1 at PP (p<0.01). One-legged {Mathematical expression} decreased from 2.95±0.22 at SL to 2.25±0.17 L·min-1 during SA (SL vs. SA, p<0.01) but improved to 2.66±0.18 L·min-1 at PP (SA vs. PP, p<0.05). Since only one-legged {Mathematical expression} increased as more oxygen was made available to the working muscles, the altitude-induced reduction in {Mathematical expression} can be implicated as being responsible for the reduction in {Mathematical expression} during two-legged cycling.

Original languageEnglish
Pages (from-to)761-766
Number of pages6
JournalEuropean Journal of Applied Physiology and Occupational Physiology
Volume57
Issue number6
DOIs
StatePublished - 1 Nov 1988

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Oxygen
Cardiac Output
Esocidae
Muscles
Partial Pressure
Carbon Monoxide
Oceans and Seas
Air

Keywords

  • Altitude acclimatization
  • Cardiac output
  • Maximal oxygen consumption
  • One-legged cycling

Cite this

@article{2bf425ca924f4adabddc75dfd3f2c2b8,
title = "Maximal cardiorespiratory responses to one- and two-legged cycling during acute and long-term exposure to 4300 meters altitude",
abstract = "During exposure to altitudes greater than about 2200 m, maximal oxygen uptake ( {Mathematical expression}) is immediately diminished in proportion to the reduction in the partial pressure of oxygen in the inspired air. If the exposure lasts longer than a couple of days, an increase in arterial oxygen content (CaO2), due to a hemoconcentration and an increase in arterial oxygen saturation, occurs. However, there is also a reduction in maximal cardiac output ( {Mathematical expression}) at altitude which offsets the increase in CaO2 and, therefore, {Mathematical expression} does not improve. The purpose of this investigation was to study the contribution of the increase in CaO2 to the working muscles without the potentially confounding problem of a reduced {Mathematical expression}. The approach used was to have seven male subjects (aged 17 to 24 years) perform one- and two-legged {Mathematical expression} tests on a cycle ergometer at sea level (SL, PIO2 = 159 Torr), after 1 h at 4300 m simulated altitude (SA, PIO2 = 94 Torr) and during two weeks of residence on the summit of Pikes Peak, CO. (pP, 4300 m, PIO2 = 94 Torr). Cardiac output limits maximal performance during two-legged cycling but does not limit performance during one-legged cycling. During the study, CaO2 changed from 189±3 (mean ±SE) at SL to 161±4 ml·L-1 during SA (SL vs. SA, p<0.01) and to 200±6 ml·L-1 at PP (SL vs. PP, p<0.05; SA vs. PP, p<0.01). Two-legged {Mathematical expression} decreased from 3.64±0.26 L·min-1 at SL to 2.70±0.14 L·min-1 during SA (p<0.01) to 2.86±0.16 L·min-1 at PP (p<0.01). One-legged {Mathematical expression} decreased from 2.95±0.22 at SL to 2.25±0.17 L·min-1 during SA (SL vs. SA, p<0.01) but improved to 2.66±0.18 L·min-1 at PP (SA vs. PP, p<0.05). Since only one-legged {Mathematical expression} increased as more oxygen was made available to the working muscles, the altitude-induced reduction in {Mathematical expression} can be implicated as being responsible for the reduction in {Mathematical expression} during two-legged cycling.",
keywords = "Altitude acclimatization, Cardiac output, Maximal oxygen consumption, One-legged cycling",
author = "Fulco, {Charles S.} and Rock, {Paul B.} and Laurie Trad and Vincent Forte and Allen Cymerman",
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Maximal cardiorespiratory responses to one- and two-legged cycling during acute and long-term exposure to 4300 meters altitude. / Fulco, Charles S.; Rock, Paul B.; Trad, Laurie; Forte, Vincent; Cymerman, Allen.

In: European Journal of Applied Physiology and Occupational Physiology, Vol. 57, No. 6, 01.11.1988, p. 761-766.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Maximal cardiorespiratory responses to one- and two-legged cycling during acute and long-term exposure to 4300 meters altitude

AU - Fulco, Charles S.

AU - Rock, Paul B.

AU - Trad, Laurie

AU - Forte, Vincent

AU - Cymerman, Allen

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